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Clinical study: Resveratrol nasal spray improves allergic rhinitis(AR) in adults

reseveratrol in vivo

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#1 malbecman

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Posted 19 March 2018 - 03:39 PM

 Never thought of this angle, it looks interesting:



Int Arch Allergy Immunol. 2018 Mar 14. doi: 10.1159/000486959. [Epub ahead of print]
Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis.

Resveratrol is a natural, nonflavonoid polyphenol, exerting anti-inflammatory activity. It has been reported that resveratrol, together with carboxymethyl-β-glucan, can reduce nasal symptoms in children with allergic rhinitis (AR). In this study, the effect of resveratrol on nasal symptoms in adults with AR was investigated.


We conducted a placebo-controlled, double-blinded study. One hundred and fifty-one adults (aged 18-60 years) with severe persistent AR were divided into a placebo-treated group (n = 50), a positive control budesonide-treated group (n = 50), and a resveratrol-treated group (n = 51). They were then treated with 2 sprays (100 µL/spray) in each nostril 3 times/day for 1 month. Nasal symptoms including obstruction, itching, sneezing, and rhinorrhea, and the levels of IgE, IL-4, TNF-α, and eosinophils in the blood were assessed at baseline and after treatment.


Adults treated with resveratrol or budesonide achieved a significant reduction in nasal symptoms compared to the placebo-treated group. The resveratrol treatment significantly decreased the IgE, IL-4, TNF-α, and eosinophil levels in the blood. In addition, the resveratrol treatment was found to improve the quality of life of adults with AR.


Our preliminary study showed that intranasal resveratrol is capable of significantly improving nasal symptoms in adults with AR.

© 2018 S. Karger AG, Basel.


Adult; Allergic rhinitis; Eosinophils; Nasal symptoms; Resveratrol

PMID: 29539616

#2 hav

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Posted 22 March 2018 - 03:56 PM

That's the 2nd recent study mentioned involving resveratrol ingested via nasal spray.  Here's a cross link to my earlier post with more detail on a nasal spray composed of a  chitosan-resveratrol complex:  http://www.longecity...in-nasal-spray/




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#3 BasicBiO

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Posted 31 March 2018 - 07:30 PM

Nice. I notice a very tiny improvement in my sinus congestion when taking large doses of rez. I wonder what they suspended or dissolved the rez into.

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