This topic is lockedAlternative NAD+ biosynthesis pathway activated by energy stress stimulates glycolysis in cardiac cells
NR supplementation represents an efficient alternative to NAM to sustain NAD+ levels in cardiac cells in conditions of energetic stress when NAMPT enzyme is repressed. Its ability to specifically stimulate glycolysis suggests that the Nmrk2 kinase could be locally associated with glycolytic complexes, which is a hypothesis under current investigation.
https://www.scienced...878648018301150
This seems to somewhat lean to support to the speculation that the whole existince for the NR path is to be a backup in times of trouble:
We show in NRC and ARC that FK866 treatment depletes NAD+ levels and triggers a robust induction of the Nmrk2 kinase
