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For those in their 30's and 40's

primary hallmarks aging early years 30s 40s

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#1 Nate-2004

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Posted 28 March 2018 - 05:47 PM


The following graphic represents the hallmarks of aging, outlined in specific mechanistic categories.

 

It's been suggested that the preliminary causes of aging, the early signs that begin in your 30's, lie mostly in the primary hallmarks section.

 

Most of the efforts in recent years have been focused on the other sections, especially around the antagonisms like mitochondrial dysfunction and cellular senescence. 

 

As a guy in his 40's, I'm more concerned with the primary hallmarks because this is probably what most people my age and younger are experiencing. It's likely that our hope lies mostly in CRISPR technology advances, not so much in NAD+ boostin, AGE breaking or the clearance of what few senescent cells have built up in these earlier years.

 

I'm a single guy in his 40's which sucks, since age has a bit of an impact on your options when dating. It's a vain world that calls for youth, attractiveness and virility and we're losing both by this age due to the slowing turnover of cells, thinning skin, the loss of collagen, hyaluronic acid, elastin, subcutaneous fat and bone density among the other aches and pains of joint and muscle soreness. We gain weight more easily and it is more difficult to lose. We can't drink nearly as much nor can we withstand the kinds of abuse most 20 year olds take on a regular basis.

 

So this thread is about these primary hallmarks and what we can maybe do about it now.

 

What are your thoughts?

 

29571377_925246537654442_895264244509618


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#2 Rocket

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Posted 29 March 2018 - 12:47 AM

You gain weight more easily in the 40s because you have less muscle... Primarily. Lift weights, eat right, build muscle, dedicated cardio at least 2x weekly. Its not like you are 70 and not digesting food the same.

Look up older bodybuilders and then tell yourself those same excuses 15 and 20 years younger than buff old guys.

Edited by Rocket, 29 March 2018 - 12:51 AM.

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#3 Nate-2004

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Posted 29 March 2018 - 01:40 PM

Who said I wasn't exercising 4x a week and doing resistance training? This thread is about early rejuvenation interventions and therapies, exercise, while good, just delays the inevitable. Delaying is fine because that buys time till these things are developed, but that's not what I'm getting at here.

 

Also, regardless of whether we lift weights or do resistance training we still don't grow muscle as quickly due to a drop in HGH among other factors, regardless of how often or how much we engage in lifting.

 

What I'm asking is where are we now with addressing the primary hallmarks, is there anything on the horizon? Is there anything accessible?

 

I think diet and exercise merely address the orange section on that graphic, the antagonistic hallmarks.


Edited by Nate-2004, 29 March 2018 - 01:45 PM.


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#4 Nate-2004

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Posted 29 March 2018 - 02:53 PM

I also want to add that this latest publication on the epigenetic clock is of significant interest as far as being a pretty key target in addressing the primary causes, halting or even reversing the early signs of aging.

 

I have avoided the telomerase inducing drugs and supplements for now until we knew more and it looks like I was probably right to do so.



#5 Mind

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Posted 29 March 2018 - 09:40 PM

Not sure why you think senescent cell clearance is not an attractive option. Seems we are getting close to having treatments. SASP affects stem cells and other normal cellular functions, so removing senescent cells could really help your health and arrest the development of the normal age-related diseases.

 

There is no silver bullet. I plan on continuing to eat well, exercise a lot, and adopt each major anti-aging therapeutic as they come along. It will likely take a combination of treatments to really turn back the clock. If you want to feel "good" and gain muscle right now, there is always HGH and testosterone boosting supplements you could use.



#6 Nate-2004

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Posted 29 March 2018 - 09:55 PM

Not sure why you think senescent cell clearance is not an attractive option. Seems we are getting close to having treatments. SASP affects stem cells and other normal cellular functions, so removing senescent cells could really help your health and arrest the development of the normal age-related diseases.

 

There is no silver bullet. I plan on continuing to eat well, exercise a lot, and adopt each major anti-aging therapeutic as they come along. It will likely take a combination of treatments to really turn back the clock. If you want to feel "good" and gain muscle right now, there is always HGH and testosterone boosting supplements you could use.

 

I think it's not an attractive option for people in their 30's and 40's. Senescent cells don't explain why there is a decline that begins around 29 or 30 years old for most people and why you can tell the difference between a 40 year old and a 25 year old. It's not the reason why we undergo early signs of aging, the things I listed in the original post. There aren't enough senescent cells at this age to have that level of effect yet people are already being affected by what I assume is slower turnover due to telomere attrition and methylation problems, which I think are more primary reasons for aging.


Edited by Nate-2004, 29 March 2018 - 10:06 PM.

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#7 Rocket

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Posted 30 March 2018 - 01:12 AM

Not sure why you think senescent cell clearance is not an attractive option. Seems we are getting close to having treatments. SASP affects stem cells and other normal cellular functions, so removing senescent cells could really help your health and arrest the development of the normal age-related diseases.

There is no silver bullet. I plan on continuing to eat well, exercise a lot, and adopt each major anti-aging therapeutic as they come along. It will likely take a combination of treatments to really turn back the clock. If you want to feel "good" and gain muscle right now, there is always HGH and testosterone boosting supplements you could use.


The boosting supplements don't work. You need very high levels of HGH and T for any results at all. Don't waste money on those things.
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#8 Rocket

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Posted 30 March 2018 - 01:17 AM

Not sure why you think senescent cell clearance is not an attractive option. Seems we are getting close to having treatments. SASP affects stem cells and other normal cellular functions, so removing senescent cells could really help your health and arrest the development of the normal age-related diseases.

There is no silver bullet. I plan on continuing to eat well, exercise a lot, and adopt each major anti-aging therapeutic as they come along. It will likely take a combination of treatments to really turn back the clock. If you want to feel "good" and gain muscle right now, there is always HGH and testosterone boosting supplements you could use.

I think it's not an attractive option for people in their 30's and 40's. Senescent cells don't explain why there is a decline that begins around 29 or 30 years old for most people and why you can tell the difference between a 40 year old and a 25 year old. It's not the reason why we undergo early signs of aging, the things I listed in the original post. There aren't enough senescent cells at this age to have that level of effect yet people are already being affected by what I assume is slower turnover due to telomere attrition and methylation problems, which I think are more primary reasons for aging.
Well its all down hill after 18 not 30! Look at Jared Leto. What is his secret? Looks early 30s.

I suspect its the aging program in part. Biologically by 30 you should have 14 and 15yo kids and you are not needed. Its gene expression killing you. Then later in life its also chemistry.

Edited by Rocket, 30 March 2018 - 01:21 AM.


#9 sthira

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Posted 30 March 2018 - 03:35 PM

...It's likely that our hope lies mostly in CRISPR technology advances, not so much in NAD+ boostin, AGE breaking or the clearance of what few senescent cells have built up in these earlier years.


I agree with this, in part, I suppose. Genetic engineering certainly shows promise; but it has shown promise for decades. Listening to the high-flying language of George Church, for example, we wonder how many more decades it'll take to untangle the many drivers of aging in humans, and then attempt to manipulate them. More time, more money, more controversy, ethics, more academic and industry drama...

SENS shows promise: "...repair, replace, render harmless..." the many malfunctioning body processes and parts that fuck us up.

Remember that none of these researchers are claiming any of this age reversal gig is a sure thing -- it'll require decades and huge sums of money, it'll need wide popular and political support. But even with full support from many directions, the obvious often-repeated fact remains that broken human parts are hard to repair, replace and render harmless. Maybe we were all just born too soon to see it happen. At least we have fora where we can come whine about all the great biostuff we may imagine that'll make us all happy. Or maybe posting here in darkness is unhealthy since it's so frustrating that we have nothing?

I'm a single guy in his 40's which sucks, since age has a bit of an impact on your options when dating. It's a vain world that calls for youth, attractiveness and virility and we're losing both by this age due to...


Well, luckily you don't have to date the entire world -- a vain world, you say, that calls for youth, attractiveness and virility. You just need to date that one cute person for a while, see how that goes, maybe it'll be great, maybe not. She should love you because you're Nate, though, not because you're 30 Seconds To Mars ageless awesome-meh-handsome dude, you're who you are, including all of your strengths and weaknesses.

But even so, I struggle with why it's so damned important to find that perfect mate with my perfect ageless body anyway? To breed? Do imagine some perfect suburban picket fence with my beautiful, smart wife and our equally lovely children? Our golden retreiver we walk the streets to show the world how amazing our lives are. Is that why? Do you seek to perfect yourself by reversing your aging in order to become yet another person raising yet more offspring in this (simulated) world?

I don't care so much about attracting another mate. Been there done that. What I'd like is to repair my body's human defects to give super human attributes -- longevity and strength and power and resilience against space radiation and anti-gravity. Get off this planet. Get out into the dark universe to explore and settle other places, as if I'm one crew member aboard a ship flying through space.

Born too early, boo hoo

So this thread is about these primary hallmarks and what we can maybe do about it now.

What are your thoughts?

29571377_925246537654442_895264244509618


My thought is that since there is nothing, practice doing nothing.

Doing nothing sucks though. I want something. But there is nothing. Face the facts. So it gets all frustrating and emotional and pissy, and here we are: desperately swallowing pills or whatever.

So far, boring ole CR and exercise are all we have for what you appear to seek. So I'm working on those behaviors while awaiting these lab miracles that may or may not even become widely available to the 99% during our pathetic little lives. We're stuck on a beautiful blue planet, we gaze up at the stars, we wonder like many other humans seem to do: what's out there, and how do we go?
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#10 Rocket

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Posted 31 March 2018 - 01:33 AM

My philosophy is i am going to keep my body as healthy as possible through sups and diet and I am going to maintain and build as much muscle as possible. Because if a breakthrough occurs, it will be easier to rejuvenate a healthy muscular person than a unhealthy frail person.

If nothing happens and I die, then I have a philosophy about what life actually is so I am not hung up on living in my current body forever.

I used to be embarrassed about my age when I was late 30s and then 40 but now I look better than most 30 year olds (physically) and people don't think I am in my 40s. When I was giving blood at the red cross the late 20s nurse who took my ID said she thought I was going to be 10 years younger than I am. My secret? Rogaine and weight lifting. And I have a bad back... I essentially have no l5s1 anymore and live with pain. I also have a very young daughter and a fulltime job but I make time for the gym and I work through the pain... So while I can appreciate a good excuse, unless you are physically unable to exercise because of a disability, there are no excuses for getting fat and losing muscle because you're simply 40 years old.

What else is that my face has actually filled out and not gotten thinner. My face is more plump like when I was teenager now then when I was 37 or 40. There is some loss of fat I think around the eyes.

I am just saying that much of what you think is inevitable at certain ages actually isn't.

Remember we are all immortal until the day we die.

Edited by Rocket, 31 March 2018 - 01:38 AM.

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#11 aribadabar

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Posted 01 April 2018 - 08:34 PM

adopt each major anti-aging therapeutic as they come along

 

Which therapies get your seal of approval?



#12 bosharpe

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Posted 01 April 2018 - 10:01 PM

I feel your frustration, Nate, I do.. But for now it seems there is nothing but swallowing a whole bunch of expensive sups on good faith. Do what you can to stay healthy and that's it really as far as I know. I liked your 'Guide to Conquering Depression' document by the way. Similar to one I've written. I'm curious - how much of what's in there do you practice?  



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#13 Nate-2004

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Posted 02 April 2018 - 03:06 PM

I feel your frustration, Nate, I do.. But for now it seems there is nothing but swallowing a whole bunch of expensive sups on good faith. Do what you can to stay healthy and that's it really as far as I know. I liked your 'Guide to Conquering Depression' document by the way. Similar to one I've written. I'm curious - how much of what's in there do you practice?  

 

Yeah.

 

 

I practice all of it, pretty consistently to one degree or another. Some of it is less important to keep up with after a long time. There is still quite a lot to do with that guide, a lot to add too.


Edited by Nate-2004, 02 April 2018 - 03:07 PM.

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