8 replies to this topic

[theone]

My 7 year old 65 lb Siberian Husky is starting to show the first signs of aging.  What Is the recommended dosage (taking into account his metabolism)?

[MikeDC]

65lb is 50% of human. 125mg will be good enough.

[Oakman]

65lb is 50% of human. 125mg will be good enough.

 

"The nutritional requirements of cats and dogs are different from those of humans and any error in feeding may have serious consequences on their health."

 

http://www.fediaf.or...ttachment&id=78

 

That, 125mg, appears high. Do some research first.  You need to be cautious, start lower, see what happens. You don't want to endanger your companion needlesslyby dosing it like a human. It is not. It's metabolism is not the same.

[TMNMK]

Provided you do this, keep notes and share if you don't mind. I don't think NR has ever been studied in a mammal between the size of a mouse and a human. So even anectodal report on your dog would probably be keenly watched. And aren't husky's ultra-energetic especially in youth? Might be an interesting parameter to watch.

Edited by TMNMK, 02 April 2018 - 10:35 PM.

[MikeDC]

Provided you do this, keep notes and share if you don't mind. I don't think NR has ever been studied in a mammal between the size of a mouse and a human. So even anectodal report on your dog would probably be keenly watched. And aren't husky's ultra-energetic especially in youth? Might be an interesting parameter to watch.

Some people shared experiences with Cats. Niagen worked wonders for them. NAD+ metabolism is the same across all mammals.

[Oakman]

 

Provided you do this, keep notes and share if you don't mind. I don't think NR has ever been studied in a mammal between the size of a mouse and a human. So even anectodal report on your dog would probably be keenly watched. And aren't husky's ultra-energetic especially in youth? Might be an interesting parameter to watch.

Some people shared experiences with Cats. Niagen worked wonders for them. NAD+ metabolism is the same across all mammals.

 

 

I shared experience with a cat of mine and NR. The end result? It helped greatly for a short time (6 months), then it went the other way. Her arthritis got worse again, and the NR stopped it's magic of keeping her inflammation at bay. So NR is stopped now. She's still with us, but, if you've had cats thru their lives, we can see the inevitable in her future.

 

NAD+ metabolism is may be the same across all mammals. But dosing and absorption are not the same. 

[theone]

Thank you for your valued feedback and suggestions. I will be keeping a close eye  on his physical and mental well- being.  Any recommendations for other medical test (aside from CBC)? I'd be happy to share any findings (pre- and post supplementation)?

[MikeDC]

Provided you do this, keep notes and share if you don't mind. I don't think NR has ever been studied in a mammal between the size of a mouse and a human. So even anectodal report on your dog would probably be keenly watched. And aren't husky's ultra-energetic especially in youth? Might be an interesting parameter to watch.

Some people shared experiences with Cats. Niagen worked wonders for them. NAD+ metabolism is the same across all mammals.

I shared experience with a cat of mine and NR. The end result? It helped greatly for a short time (6 months), then it went the other way. Her arthritis got worse again, and the NR stopped it's magic of keeping her inflammation at bay. So NR is stopped now. She's still with us, but, if you've had cats thru their lives, we can see the inevitable in her future.

NAD+ metabolism is may be the same across all mammals. But dosing and absorption are not the same.

Did you try intermittent dosing? Maybe long term dosing causes negative feed back loop?

[Oakman]

 

 

 

Provided you do this, keep notes and share if you don't mind. I don't think NR has ever been studied in a mammal between the size of a mouse and a human. So even anectodal report on your dog would probably be keenly watched. And aren't husky's ultra-energetic especially in youth? Might be an interesting parameter to watch.

Some people shared experiences with Cats. Niagen worked wonders for them. NAD+ metabolism is the same across all mammals.

I shared experience with a cat of mine and NR. The end result? It helped greatly for a short time (6 months), then it went the other way. Her arthritis got worse again, and the NR stopped it's magic of keeping her inflammation at bay. So NR is stopped now. She's still with us, but, if you've had cats thru their lives, we can see the inevitable in her future.

NAD+ metabolism is may be the same across all mammals. But dosing and absorption are not the same.

Did you try intermittent dosing? Maybe long term dosing causes negative feed back loop?

 

 

Yes, after the initial success, when she began vomiting after eating more often (than usual, which she had done anyway). So first I went of NR every 3 or 4 days, then reduced the dose down to a low of about 25 mgs (of actual NR, excluding filler). Nothing seemed to work as before, so I stopped. I may try again, but at this point she is stable, just old and she get every indulgence a cat can have. Meanwhile she gets her Depo-Medrol shot about every 6 wks, plus ear delivery of Prednisolone once or twice daily, and that keeps her from itching pretty much.  Then, for the arthritis pain and limp, bucal Buprenorphine occasionally when I see her limp is bad.  Sounds like a lot, but she's a real soldier, and still the boss of 4 cats, regardless of her infirmities.

 

I haven't tried CBD oil, but may as it's readily available here. However I'm uncertain of the dosing.