Hello, please excuse me if this is the wrong area to post, but I can see few others, so here it will have to be.
This is just my second post, the first being my introduction and I joined here in order to both contribute, and I hope, be given back to. I hope I can use the expertise in biochemistry I have to help others, as of now, I'm still finding my way around.
I am currently in need of memantine, and quickly. I did some searching online and found the first site, after a little digging to have been reported by several as a scammer, so obviously I'm not about to touch them with a ten foot pole.
My situation is..well i'm likely to be thrown out of the frying pan and into the fire, so to speak. I have to deal with chronic and severe pain, partly regular, run of the mill, although severe joint pain after falling on glass as a kid, first, which penetrated my patellar tendon and left bits of glass shrapnel and bone fragments both in and behind the tendon itself and penetrated through into the joint itself. Had to break off the largest part, that was weighing me down and drag myself home in order to get transport to hospital.
Not that long after surgery on the joint, during recovery, I got set upon by a pack of chav garbage, attacked, my knee stamped on repeatedly, along with my head. Only reason it stopped, IMO, is when I managed to open and use a pocket knife, after that the cowardly little vermin ran off, leaving me for dead. Little shits just hated anybody not a nasty little pikey turd basically. And being classically autistic isn't really compatible with being infected by chavitis. So, public enemy no,1, that was me from day one,
Essentially the knee injury changed my walking gait as a compensatory mechanism, over the years it badly damaged both my hip joints and left me with trochanteric bursitis on both sides, more or less leaving me not completely immobile, but with poor mobility, both due to the joint issues and due to pain. Can't get far these days (and I'm only in my damn early 30s)
And worse, I am about to end up neck ankle deep in shit from the ears up, because I had a recent infection of a foot, and required some temporary additional pain relief over and above my usual. The usual being something that despite plenty of inadequacies and it being barely enough to avoid a most unpleasant withdrawal situation (originally on oxycontin 80s, twice daily, with further breakthrough IR oxy added after an eye injury some little bag of slime caused, after they set up the conditions for me to have a nasty lab accident, involving corrosives.and water-reactive compounds cause a sudden and unavoidable overpressure blast powerful enough to knock my goggles up off my eyes at the unfortunate under-shot angle the resultant torrent of superheated corrosive alkali hit at, almost blinding me.
Result was being viewed with more suspicion than I already had to deal with from the medical establishment, near enough like a criminal, just for being in agony after almost being blinded (I came, I'm told, within ten seconds of being blinded permanently, and would have, had I delayed for even a few seconds in forcing my eye open under the tap and washing my eyes out.)
After this recent foot infection, a severe one and one that left me completely bed-bound and pissing in a bottle at first, whilst a cocktail of antibiotics did its work and some meager scraps of additional pain relief that both myself and doctor agreed was only ever meant to be temporary. Healed up, and then requested a taper. A bank holiday got in the way and I was given just enough to make it a few days over the weekend without going into severe physical withdrawal from my pain meds. I came back, and requested being tapered back to baseline, To begin the process and rather than try to do it in fits and starts, piecemeal to just get it done.
Now, unfortunately I am to be punished. Damn dr wants me off my pain meds, possibly entirely, never mind the fact I have an appt with a specialist pain clinic in the next month or so. I don't think I can stop him. I'll certainly try but I do have a backup plan thankfully. He's even bitching himself silly about my seizure prophylaxis and response medication (I take chlormethiazole for it, it isn't a licensed indication in the BNF, for treating seizures, BUT, I've found it to be astonishingly little prone to causing tolerance or physical dependency. Its a GABAa positive allosteric modulator, for the barbiturate/picrotoxin binding site, and acts very similarly in terms of the mode of its gating the GABAa receptor chloride channel in the absence of GABA binding, and is similar in the kinetics of its effects on Cl- flux through the channel, prolonging and intensifying GABAergic inhibitory currents although unlike benzodiazepines, but similar to the barbiturates doesn't need GABA to be bound before potentiating the chloride current, although chlormethiazole is a bit different to barbs, in that it doesn't possess the undesirable AMPA receptor negative allosteric modulatory effects that they do) Very little tolerance and no physical dependency, but all the same I still need to take the stuff, because the reason I'm taking it, the seizures, still needs treating. Although AFAIK that is a lesser risk than the pain meds leading to me being treated like a damn criminal.
Namely, memantine and naltrexone in combination is my backup plan, in addition to kratom, which I'll stock up on I'm experienced with memantine, but never with the naltrexone protocol I have in mind. Ordinarily the latter is a MOR antagonist, and to put it simply, by binding with a far higher affinity than the opioid agonist ligand, kicks opioids off their receptors and in the doses normally used, in an opioid dependent patient, will throw them into an extremely severe precipitated withdrawal, far, far in excess of the severity that would be the case if the same patient were forced to 'cold turkey'.
It can be used in ultramicrodose levels however, not the 25-50mg levels used in treating say, former heroin addicts who just need something present to make a relapse pointless. It also interacts with a protein called filamin-A, in a way that helps prevent beta-arrestin II recruitment after opioid induced G-protein activation, and stamps on tolerance HARD, when used in doses beginning at somewhere between 500-750 nanograms daily, a solution being prepared by serial volumetric dilution from standard tablets, as no preparation intended for this specific usage type exists.
Also believed to block a switch from the usual inhibitory type coupling of Mu-opioid receptors from Gi/o to GgammaS, which causes a reversal of typical opioidergic effects.
So I need some assistance, in securing in particular the memantine, I've taken it before, although don't have a supplier, since it was gifted to me rather than bought. I'm aiming to buy in powder form rather than tablets although I'll take what I can get. I've so far found nothing but scammers. And aside from the powerfully inhibitory effect upon both tolerance acquisition and existing tolerance, memantine reverses most of the cognitive and memory issues I have to deal with almost completely. It is a lifesaver for me,
I would dearly appreciate any help that anyone can give me, by pointing me towards somebody who won't just take what money I have and run off with it. I've got enough savings to do this, but not much more, especially since I've been saving up over time to replace a vacuum pump in my lab.
With gratitude,
Lestat Rett
