Hi everyone,
I've done a search and there doesn't seem to be a lot of discussion about Thioredoxin.
I've seen two studies that make me think this is worth investigating further:
https://onlinelibrar...1111/acel.12596
This has been posted on the forum before. Thioredoxin Reductase is correlated with long-lived species and can increase lifespan...
https://www.ncbi.nlm...pubmed/28179506
This is the more intriguing study IMHO. Thioredoxin basically cures mice of hypertension for really long periods of time and mice made with more Thioredoxin will never get age-related hypertension.
Thioredoxin redox reactions are highly conserved between species, so there is no reason to believe these beneficial effects wouldn't translate. Since this looks like a potential game-changer, we will probably never hear about it again from the medical community.
Here are my questions:
1. Since Thioredoxin Reductase is just the reduced version of the same reaction, is it safe to assume that
Thioredoxin would have all the same benefits, and so we can just focus on that one?
2. rhTRX exists and is being sold.
a. Would it be effective?
b. Best route of delivery?
c. Possible side effects?
d. It is expensive and would require a group buy, assuming it pans out as an option, who would be interested?
This definitely doesn't get enough attention here. Another study showed that transgenic mice over-expressing TRX1 have an increase in mean (35%) and even max (22%) lifespan. That's right up there with a small selection of the most powerful anti-aging interventions. Although transgenic mice and "from birth" are not exactly translatable, it is bound to have health benefits.