15 replies to this topic

[magniloquentc0unt]

I have taken ssri in the past (prozac)  and they have left me with dysfunctional sexuality

i have problems with maintaining erections and reaching orgasm

 

in the past ive tried other option for my mild depression / dysthimia and it only partially helped

im in dire need of something that increases my motivation and drive in life, and also my cognition and memory has become horrible in the past years.

concentrating on tasks is really difficult as i find myself switching topics so fast.. never really enter a productive flow state.

 

for sexuality my inderstanding is that it is auspicable something with 5ht1a agonism and 5ht2a/c antagonism. am i correct?

what would be your suggestions in that sense?

 

i was thinking a long term vortioxetine / trazodone combo

[magniloquentc0unt]

so i get nothing but a downvote? whatever...

[sant2060]

I managed to get my pdoc to suscribe me Agomelatine.

Finishing my 1st 3 week on 25mg dose, then will do liver probes.

For me it is the best thing I ever took. No sides so far, libido and orgasms higer intensity and most important, 1st thing ever to do something for my anhedonia.

Your mileage my vary, what I noticed about it is that it does wonders for my anxiety and helps with my stress response.

If liver will be ok, I'll try with 50mg, because there is some room for improvement in motivation category.

PS, i had more than a decade of dysthimia, anhedonia and atypical depression.

[magniloquentc0unt]

hi sant, thanks for your answer
your symptoms sound exactly like mine, and i also have a big box of valdoxan at home - the other option i was considering was valdoxan - agomelatine.. i had tried it for a week in the past but didnt feel much

how long did it take for you to start working? 1 week?

[sant2060]

hi sant, thanks for your answer
your symptoms sound exactly like mine, and i also have a big box of valdoxan at home - the other option i was considering was valdoxan - agomelatine.. i had tried it for a week in the past but didnt feel much
how long did it take for you to start working? 1 week?

Well, compared to SSRI/SNRI it is totaly different...all others had at least some effects first two weeks (mostly negative, anxiety would to up)...agomelatine is subtle.

After aprox 10 days I noticed I'm not in such bad mood as usuall in the mornings. Not that I was exctatic or something, just a drop in bad mood and anxiety that I usually have in 1st half of day.

Antianhedonic effects started after two weeks. Again, not extasy or anything, just noticed I started to enjoy music again.

So, subtle but steady improvement. Yesterday was čast day of my 3rd week, and I've spent like 2 hours listening and enjoying music. Something I couldnt do for 15 years.

But again...for some people some AD work, for some dont. One week is however to shot to write off agomelatine.

Just be carefull about your liver. In some rare cases it can do a serious damage.

[Nate-2004]

@magniloquentc0unt

 

Sorry about all the downvoting on this board, we have a couple of trolls who like to go through and mark down people's posts, it's kind of why I like the reddit system better where reputation matters in a vote, and the only vote is up or down.

 

As for reversing SSRI sexual dysfunction, replace your anti-depressant with 30mg of saffron, it's just a pinch of the stuff each day. It's a little expensive and not covered by insurance, but it works both as an anti-depressant and a means of reversing sexual dysfunction in most people.

 

https://www.ncbi.nlm...pubmed/22552758

 

Also you may want to add the following for better results, though warning, this could make you pretty horny all the time.

 

Empty Stomach:

 

EGCG

Cocao

Vitamin B6

 

Full stomach:

 

Lithium Orotate 5mg elemental lithium

 

The reasoning here is that it optimizes the production of dopamine by reducing COMT, upregulating tyrosine hydroxylase and providing B6 as a substrate.

 

[Ruth]

http://vestnik.szd.s...ticle/view/2484 https://journals.lww...in_major.1.aspx

[Mind_Paralysis]

Hmm... dysthymia and sexual dysfunction.

 

Have you considered trying Aripiprazole? As has previously been mentioned on the forums, certain atypical antipsychotics were early on found to be the only things that could bring certain anhedonic depressives back into action, and Aripiprazole is the best option easily available in most jurisdictions when it comes to AP's.

 

I'm thinking specifically about its partial D3-agonism - as you know, compounds which affect this receptor, are known to have dramatic effects on sexuality.

 

(aripiprazole specifically have been known to cause hypersexuality, but considering you have hyposexuality, I don't think you're in any danger of that...)

[jaybird10 2]

Hmm... dysthymia and sexual dysfunction.

Have you considered trying Aripiprazole? As has previously been mentioned on the forums, certain atypical antipsychotics were early on found to be the only things that could bring certain anhedonic depressives back into action, and Aripiprazole is the best option easily available in most jurisdictions when it comes to AP's.

I'm thinking specifically about its partial D3-agonism - as you know, compounds which affect this receptor, are known to have dramatic effects on sexuality.

(aripiprazole specifically have been known to cause hypersexuality, but considering you have hyposexuality, I don't think you're in any danger of that...)

ive wanted to try low dose aripiprazole as an add on to pristiq. I worry about (DAWS) . I wonder if lower dosages are safer than higher ones. Ive read conflicting data.

[CWF1986]

Buproprion might be a good fit.  If you have anxiety issues it may not be right for but as far as lack of motivation, memory, and focus it was great for me.  It really boosted libido for me too.  I have taken it before and the only reason I don't anymore is because it doesn't play well with adderall as far as anxiety and blood pressure goes and adderall  does a much better job for the cognitive symptoms and even a little bit for the restlessness factor of my adhd.  

 

It would most likely be a lot easier to persuade a physician into prescribing too.  

[sentics]

Buproprion might be a good fit.  If you have anxiety issues it may not be right for but as far as lack of motivation, memory, and focus it was great for me.  It really boosted libido for me too.  I have taken it before and the only reason I don't anymore is because it doesn't play well with adderall as far as anxiety and blood pressure goes and adderall  does a much better job for the cognitive symptoms and even a little bit for the restlessness factor of my adhd.  

 

It would most likely be a lot easier to persuade a physician into prescribing too.  

 

did it affect your libido right away or only after a couple of weeks? because i took it for 1-2 weeks at some point and never felt a libido boost

[CWF1986]

Some right away and reached and stayed at peak levels after 5 weeks.  

 

Wellbutrin as an antidepressant in general takes 5 weeks to start working at its fullest for me.  

[magniloquentc0unt]

thanks for the suggestions folks

thanks for the saffron suggestion, i had heard of it a while back but never tried it. i am going to go buy some common saffron at the store and give it a go.

as for the dopamine, i am not sure. i fall victim to stuff like videogames and porn use very easily and use it compulsively, almost.

not sure what this means! but ive never had too great results with ritalin or with mucuna etc...

also my libido is very high actually, its just i have often erectile issues and can not reach orgasm (if i do, it takes a super long time!)

i had tried bupoprion a couple years back for a month or so and i only noticed it made me more nervous and more easily to snap at coworkers.... cant recall any benefit tbh! but it might deserve a more serious trial

 

i am giving agomelatine a proper go at the moment, i think im about at day 7-10 of 50mg. so far so good, its subtle but i feel more incline at doing multiple tasks instead of stagnating without being productive... im alternating this to microdosing lsd, about 10mcg every 3/4 days.

 

interesting results in the motivation/drive area, although nothing drastic

not much to report in the sexuality area sadly

also cognitive wise its not doing miracles. vortioxetine was better but had sexual sideeffects

[CWF1986]

If your libido is fine but you have those other issues I'm starting to think that this isn't a dopaminergic issue.  It could be more related to hormones and blood flow.  I'm not too familiar with supps that relate to that.  

 

SSRIs have indirect effects with more than just other monoamines so you shouldn't just immediately assume this a dopamine issue.  

[magniloquentc0unt]

i agree and i have been suspecting something similar for a while, but never managed to make sense out of it.

for example, dopamine agonists are known to cause all sorts of compulsive disorders like gambling, videogaming and porn addiction.. well im quite already in that boat and dont want to aggravate!

in the end it is somehow a misconception that only dopamine is responsible for sexuality, serotonin is also highly involved!

the only thing that could wouch pro dopamine is that i have decreased sensitivity to pleasure (sexual and not - eg general anhedonia)

[normalizing]

where do you get your lsd from??