Hello, I have been doing some research into finding the best natural Maoi-B inhibitor, after stumbling across a couple peer revied studies I'm not sure which one is accurate. One study found the IC50 inhibition of Maoi-b by Acacetin 0.049 μM.
(Acacetin inhibited MAO-A and -B with IC50 values of 0.121 and 0.049 μM, respectively, which indicates a more preferential inhibition by acacetin of MAO-B over MAO-A )
, However, I found an older study which shows the IC50 inhibition of Maoi-b by Acacetin is 2460 μM
(flavonoids were isolated and identified as acacetin (I), 5,7-dihydroxy chromone (IlL diosmetin (III), apigenin (IV), eriodictyol (V) and luteolin (VI). IC5owere determined as following: I, 2.46; II, 0.19; III, 2.11 mM, and the others show- ed weak inhibition).
I'm also curious about the practicality of it working in a human application.
I'm interested in the application for helping focus since I have ADHD.
Any input on this topic could be useful
Chaurasiya ND, Gogineni V, Elokely KM, et al. Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B. Journal of Natural Products. 2016;79(10):2538-2544. doi:10.1021/acs.jnatprod.6b00440.
Han YN, Noh DB, Han DS. Studies on the monoamine oxidase inhibitors of medicinal plants I. Isolation of MAO-B inhibitors fromChrysanthemum indicum. Archives of Pharmacal Research. 1987;10(2):142-147. doi:10.1007/bf02857780.
