6 replies to this topic

[Karomesis]

http://www.cambridge...cts/wyeth/myo30

do any of you guys think it would be highly unwise to ingest this as a 27 year old already muscular guy?

I was thinking of taking it along with some other experimental drugs I'm already on.

I wasn't worried about the muscle mass like having a 25 inch neck, but the effects on my ticker. I don't care how strong I am, without a healthy heart it's worthless as you all know.

Why can't technology move FASTER. [ang] I feel like a witch doctor performing a rain dance with all this stuff.

[zoolander]

Has this drug been cleared for use? I states on the website that MYO-029 is still in PhaseI/II clinical trials, results expected late 2006.

What sort of other experimental drugs are we talking about?

In regards to MYO-029 effecting the heart...well this is yet to be seen. It is an anti- myostatin monoclonal antibody. So its function essentially will be to block skeletal-muscle-specific expression of myostatin and hence increase muscle size by inhibition of inbuilt genetic controls.

It says skeletal-muscle-specific and hence should not directly effect cardiac muscle. However, it may and most likely will effect the cardiac muscle indirectly by increasing strength, thus augmenting the pressor response.

---Definition of pressor: Causing, or giving rise to, pressure or to an increase of pressure; as, pressor nerve fibres, stimulation of which excites the vasomotor center, thus causing a stronger contraction of the arteries and consequently an increase of the arterial blood pressure.---

Overtime, increases in arterial blood pressure means that the left ventricle needs to pump harder to overcome the arterial pressure (this will be shown as an increase in systolic pressure) and like skeletal muscle the cardiac muscle will hypertrophy so that it is strong enough to overcome the load imposed on it. So in short, it will probably end up messing with your ticker

My advice, unless you have a genetic defect i.e. muscular dystrophy, stay away from it. I personally would not be messing around with regulation of genes.

[Karomesis]

Zoolander, don't you get bored with your current biological makeup?


I do. I want to speciate as soon as possible. From my DNA to my cognitive function I will represent someone alogether different from homo sapiens.

People get tatoos now to say they're different......they ain't seen nothing yet [lol]

[zoolander]

No I don't get bored easily.

If you take away all the fancy fillings that we fill our day with to entertain us, then what do we have? A boring existence. Life is mundane. It is this truth, that for some reason, drives us to run away from reality.

I think you need to ask yourself why you want to be super human? Or why you want to **** with your DNA

I dont need to try and tweak my body beyond normal physiological levels. My aim is to maintain it at its current level for as long as possible. I am satisified with what I have and who I am.

[Karomesis]

[/quote]If you take away all the fancy fillings that to fill your day with to entertain you then what do you have? A boring existence. Life is mundane. [quote]

Perhaps for some, my imagination is a world unto itself.

[kismet]

Just discovered this thread, I know it's old.

The discussed anti-body, Myo-029, is definitely a failure for its inteded purpose (treating muscular dystrophie) and a great disappaiontment to all those who believed it could surpass anabolic steroids and/or hGH in efficacy (I know lots of bodybuilders and athletes who panicked "oh, no this will give every sedentary couch potato rony coleman muscles").
Full study:
http://www.musculard...t/view/1192/51/

Whether myostatin in itself is just a minor regulator of muscle anabolism or just Wyeth's Myo-029 failed, remains to be seen, as far as I know.

Zoo, it is one thing to be satisfied with one's body, but another thing not to want to improve anything if it can be safely done. Though, let's not start a philosophical discussion on that topic, let's discuss science.

Edited by kismet, 08 June 2008 - 05:01 PM.

[triguy]

Just discovered this thread, I know it's old.

The discussed anti-body, Myo-029, is definitely a failure for its inteded purpose (treating muscular dystrophie) and a great disappaiontment to all those who believed it could surpass anabolic steroids and/or hGH in efficacy (I know lots of bodybuilders and athletes who panicked "oh, no this will give every sedentary couch potato rony coleman muscles").
Full study:
http://www.musculard...t/view/1192/51/

Whether myostatin in itself is just a minor regulator of muscle anabolism or just Wyeth's Myo-029 failed, remains to be seen, as far as I know.

Zoo, it is one thing to be satisfied with one's body, but another thing not to want to improve anything if it can be safely done. Though, let's not start a philosophical discussion on that topic, let's discuss science.

 

 

BUT did it work????  YES!

 

 

There are NUMEROUS reasons (mainly $$$$) why pharm companies stop trials..