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Amino Acid Delivered Through Nanofibers Reverses Atherosclerosis

atherosclerosis

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#1 Rocket

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Posted 25 May 2018 - 08:10 PM


https://www.medicaln...cles/321788.php

 

They don't say what the amino acid sequence is....


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#2 Daniel Cooper

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Posted 28 August 2018 - 03:31 PM

Well, the FDA being what it is you might have access to this technology in 10 to 20 years.

 

 

 


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#3 Mind

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Posted 28 August 2018 - 04:52 PM

1. Great result.....in mice.

2. Side effects?

 

Good to see more specific targeted nanotech making it into medicine.


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#4 Phoebus

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Posted 28 August 2018 - 05:10 PM

 

 

Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery
First published: 12 February 2018
 

 

Abstract

Coassembled peptide amphiphile nanofibers designed to target atherosclerotic plaque and enhance cholesterol efflux are shown to encapsulate and deliver a liver X receptor agonist to increase efflux from murine macrophages in vitro. Fluorescence microscopy reveals that the nanofibers, which display an apolipoprotein‐mimetic peptide, localize at plaque sites in low density lipoprotein receptor knockout (LDLR KO) mice with or without the encapsulated molecule, while nanofibers displaying a scrambled, nontargeting peptide sequence do not demonstrate comparable binding. These results show that nanofibers functionalized with apolipoprotein‐mimetic peptides may be effective vehicles for intravascular targeted drug delivery to treat atherosclerosis

 


Edited by Phoebus, 28 August 2018 - 05:11 PM.

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