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"Substantial evidences suggest that naturally occurring polyphenols exhibit beneficial effects on many aspects of T2D and its complications via strengthening NAD+ biosynthesis and restraining NAD+ breakdown pathways to boost NAD+ levels [23–26]. Consistent with these studies, our results revealed that PSPC dramatically restored NAD+ levels in the livers of HFD-treated mice by heightening NAMPT level and diminishing Molecules 2017, 22, 1315 9 of 16 PARP1 level, which might be responsible for many aspects of its beneficial effects on T2D and its complications.
It is well established that intracellular NAD+ level is modulated by cellular stresses including oxidative stress [27,28]. Oxidative stress is reported to depress NAMPT-mediated NAD+ biosynthesis during metabolic syndrome and aging [29,30]. Accumulated evidence reveals that PARP1 is largely promoted by oxidative stress under various pathological conditions, resulting in NAD+ depletion [31,32]. In the present study, our results showed that HFD induced a severe oxidative stress, which was attenuated by PSPC in mouse livers. As strong antioxidants, naturally occurring polyphenols are well demonstrated to boost intracellular NAD+ levels [24–26]. Therefore, our findings indicated that PSPC might improve NAD+ metabolism to restore hepatic NAD+ levels in HFD-treated mice via its antioxidant effect."
There seems to be further research being done:
Anti-obesity and antioxidative effects of purple sweet potato extract in 3T3-L1 adipocytes in vitro.
PSP powder can be had on Amazon and elsewhere, the coloring/extract is a bit harder to find. Not sure exactly what the difference is, if any, other than the color may be a liquid, not powder. May be something to add to the diet?
