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Selegiline or Rasagiline

selegiline rasagiline dysthimia atypical depression pssd

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#1 magniloquentc0unt

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Posted 29 May 2018 - 01:25 PM


Hello folks

Its been years that im trying to find the best molecule for my needs, and it still eludes me

 

long story short, im looking something to motivate me in life

i pass the days doing almost nothing, feel no drive, no reward, nothing really interests me.

i have a bit of memory impairment, concentration issues, brainfog etc. not feeling melanchonic or anything thou

im at a point in life where this has to stop and, despite trying hard, i cant push myself out of the situation

 

i dont feel im particularly sad or anything, but i might certainly be depressed. 

my shrink thinks its dysthimia and i tend to agree, probably with a bit of ADD inattentive

 

we tried many different meds but they all had annoying side effects or were not working or didnt quite hit the spot.

i also had used fluoxetine (prozac) years back, and it had ruined my sexuality in a semi permanent fashion 

with this i mean that i have only recently (about two years ago) started to get better. after 7 years of discontinuing.

thats to say that i dont really want to try any SSRI again. if ever, then with a concomitant "antidote".

ritalin does not really work for me and only makes me a bit agitated.

 

anyhow, ive had decent success with the antidepressant Moclobemide (Aurorix), which is a reversible MAO-A. the issue is that it must be dosed very often, and it kinda did not really motivate me to do things, but did give energy and put me in a better mood. So due to my positive reaction to monoamine oxidase inhibition, ive come to the conclusion that Selegiline or Rasagiline are the next step for my sort of "anergic, atypical disthymia"

 

 

 

Ive been reading up on the two and trying to figure out whats the difference, but i cant make any sense of it:

my understanding is that Selegiline metabolizes to amphetamine derivatives and as such inherently has a certain "neurotoxic" activity; whereas rasagiline metabolizes to aminoindan which has intrinsic neurotrophic effects per se.

to me it seems that rasagiline is vastly less studied for scenarios that vary from parkinson. 

 

on this website https://www.selegiline.com/ there is a lot of condensed information about selegiline with according studies. some of these i found very interesting and tempting. for example:

     Selegiline has immune-system-boosting and anti-neurodegenerative effects. Its use increases the level of tyrosine hydroxylasegrowth hormone, cerebral nitric oxide and the production of key interleukins.  "

 

especially the increase of growth hormone is something i would very much appreciate. Does anyone know if rasagiline has this property too?

 

A critical review of evidence for preclinical differences between rasagiline and selegiline

https://www.scienced...210533612000597 ---> this seems a good paper but i dont have access to the full version

TLDR:

how do the two compare? which one is best (and why) for anergic disthimia?


Edited by magniloquentc0unt, 29 May 2018 - 02:25 PM.


#2 John250

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Posted 10 October 2018 - 03:47 PM

Selegiline is irreversible in higher doses but reversible in lower doses. I wonder if the same applies to Rasagiline. What stands out is the most benefit to me is

“appears to be especially useful in dealing with non-motor symptoms like fatigue.[5][6][7]”

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#3 MichaelFocus22

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Posted 17 October 2018 - 02:46 AM

 What you need to realize is that there is no perfect drug. There is no perfect cure and no perfect answer, we are degenerate individuals who were gimped from utero. An example is my ADHD: if you look in my ADHD reference, thread I discuss chronic thoughts of susicide and having little to no motivation to do anything, yet I still find a way to manage. Obviously, my life is faar from perfect. I basically lost everything I ever worked for. Yet, I keep going,just put one foot and front of the other. Keep plugging away and keep going. I gurantee I've been more depressed than you. There were days where I was going to end my life.  No one is going to help you but you. A chemical while very laudible is a means to end unless you know the root cause. My problem is that it's genetic so I have no implicit answer. Goodluck  to you.Remember you get one life, there are NO do overs.



#4 magniloquentc0unt

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Posted 17 October 2018 - 12:08 PM

@john: that last line you cited refers to rasa or sele?

 

 

@michael: 

 

i agree with some parts of your answer. the change has to come from within, you cant hope that a pill will live your dream life for you.

although medications can put you in the correct mindset. ive experienced this multiple time, and ive just sat there doing what i always did before which eventually brought me to this dissatisfying situation. Frankly i think that in the end i have some sort of fear of people and of being judged that paralizes me and masks as other things

 

i am now trying again, explicitly changing my lifestyle while riding the wave ;)



#5 MichaelFocus22

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Posted 17 October 2018 - 02:41 PM

Exactly, just keep plugging away and don't quit. Eventually if you keep plugging away enough you WILL get somewhere tenacity and grit is what we people with ADHD are KNOWN for. Even if you fail, just one foot in front of the other and do it again.



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#6 John250

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Posted 17 October 2018 - 04:22 PM

@john: that last line you cited refers to rasa or sele?


@michael:

i agree with some parts of your answer. the change has to come from within, you cant hope that a pill will live your dream life for you.
although medications can put you in the correct mindset. ive experienced this multiple time, and ive just sat there doing what i always did before which eventually brought me to this dissatisfying situation. Frankly i think that in the end i have some sort of fear of people and of being judged that paralizes me and masks as other things

i am now trying again, explicitly changing my lifestyle while riding the wave ;)


Rasagiline. Link was from Wikipedia





Also tagged with one or more of these keywords: selegiline, rasagiline, dysthimia, atypical depression, pssd

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