1 reply to this topic

[eighthman]

https://singularityh...avszn17lkx8p02i

 

This article is worth reading for its clarity.  I was losing confidence in the senolytic approach but this offers hope - particularly in regard to the negative power of a few senescent cells and the unfortunate staying power of their influence. Very positive.

[treonsverdery]

the article says

 

"The team next gave mice transplanted with senescent cells a cocktail of two drugs (“D+Q”): dasatinib, used to treat leukemia, and quercetin, a plant chemical often found in red wine, kale, and a variety of unregulated supplements.

These are the first senolytics reported, and the team found them by analyzing the different pathways senescent cells use to ward off suicide. Even more importantly: they work in human tissues to kill off senescent cells and reduce their inflammatory secretions.

In young mice transplanted with senescent cells, just three days of D+Q treatment efficiently killed off the aged cells. The recipients were also spared from premature aging, in that they remained relatively physically fit even after the senescent cell assault."

 

"

Even more impressively, they lived 36 percent longer (that’s huge!) without an increased risk of getting cancer or other age-related diseases. That is, they had a longer healthspan—the current goal of anti-aging research. “We can say with certainty that senescent cells can cause health problems in young mice, including causing physical dysfunction and lowering survival rates, and that the use of senolytics can significantly improve both healthspan and lifespan in much older naturally-aged animals,” said Kirkland."