9 replies to this topic

[Yojimbo94]

consumption a bit 'uridine and seems to work well, but I do not understand why when I take methylcobalamin 1000mcg, my best mood but brain fog and failure to speak well, has anything to do with methylation?

[experimenting]

It does. Don't get taken in by all this methylation garbage. Yasko etc is a quack. It's not as easy as blaming everything on a single gene then megadosing a vitamin as a solution.

What are your issues and goals?

[Yojimbo94]

my (I think) is a dopamine problem, after a serious addiction to the internet and porn, precisely every time I do something particularly addictive (food, internet) I feel as if my receptors unrighte too fast and I feel all the effects of a low dopamine, I wanted to integrate methylcobalamin and methylfolate as a support to uridine to avoid a risk of deficiency, but I noticed that it gives me a severe brain fog

[John250]

my (I think) is a dopamine problem, after a serious addiction to the internet and porn, precisely every time I do something particularly addictive (food, internet) I feel as if my receptors unrighte too fast and I feel all the effects of a low dopamine, I wanted to integrate methylcobalamin and methylfolate as a support to uridine to avoid a risk of deficiency, but I noticed that it gives me a severe brain fog

You should get genetic testing done to see what you need. You might benefit more from adenosylcobalamin and/or cyanocobalamin.

[experimenting]

Try uridine on its own first. Isolate and see if that helps then maybe add a regular B complex and see how you go. Methylation is overrated. A methyl b supplement wrecked me for a week.

[Yojimbo94]

uridine seems to work, I have also found the optimal quantity that is not drowsiness and cerebral fog from sublingual 70mg, but I think it has become intolerant to b6 after taking it for a few months together with zinc and magnesium (ZMA) and now when I take the multivitamin seems to give me fatigue and brain fog. cyanocobalamin and folic acid does not seem to give me the same problems of the methyl version I will continue to test to see other side effects

[Kimer Med]

Methylcobalamin works best when your oxidative stress and nitric oxide (NO) levels aren't high. If they are high, then the Methyl-B12 can be oxidized, which can make you feel terrible.

 

You might try Hydroxo-B12 instead, which will help reduce NO. Don't use methyl-folate while you're taking Hydroxo-B12.

 

Avoid Folic Acid. It's an evil compound not found in nature that badly mucks with folate metabolism.

 

Another related issue may be related to BH4, which is required to create most neurotransmitters. BH2 to BH4 recycling requires methyl-folate and SAMe. If your methylation pathways are messed-up, you may not be making enough of either. In addition, BH4 is easily damaged by oxidative stress.

[Yojimbo94]

apparently also cyanocobalamin seems to send me into an euphoric state (high serotonin) but cause me fog celebrale, difficulty talking and thinking well (I think low dopamine) I can not understand why

[Yojimbo94]

One of the strangest things is that it takes 15-20 minutes of internet to exhaust my dopamine reserves and notice all the negative effects (less confidence, procrastinate, depression, etc.) why?Dopamine neurons problem or dopamine receptor
One of the strangest things is that it takes 15-20 minutes of internet to exhaust my dopamine reserves and notice all the negative effects (less confidence, procrastinate, depression, etc.) why?Dopamine neurons problem or dopamine receptor

[ironfistx]

Methylcobalamin works best when your oxidative stress and nitric oxide (NO) levels aren't high. If they are high, then the Methyl-B12 can be oxidized, which can make you feel terrible.

 

You might try Hydroxo-B12 instead, which will help reduce NO. Don't use methyl-folate while you're taking Hydroxo-B12.

 

Avoid Folic Acid. It's an evil compound not found in nature that badly mucks with folate metabolism.

 

Another related issue may be related to BH4, which is required to create most neurotransmitters. BH2 to BH4 recycling requires methyl-folate and SAMe. If your methylation pathways are messed-up, you may not be making enough of either. In addition, BH4 is easily damaged by oxidative stress.

 

What is the reason you can't take methyl folate while using hydroxocobalamin?