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What do you think of supplementing with Vitamin B4 (adenine)?

adenine b4

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#1 Phoebus

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Posted 29 August 2018 - 01:00 PM


curious about what folks think of oral supplementation with vitamin B4 ie adenine and how this might affect mito? 

 

Would it just pass thru the digestive system and out the other end? or would it be taken up by cells and incorporated into the mito with beneficial affects? 

 

Info is basically non existent. Google searches lead nowhere. 

 

there is one pure adenine product available on amazon currently 

 

 

Vitamin B4 also known as Adenine is the member of the Vitamin B-Complex family. Vitamin B4 is also one of the water-soluble vitamins.  Adenine act as a  compound that acts as a co-enzymewith other compounds such as vitamins and is mostly known for its function  speed up the processes of producing energy in our body. That is why it is essential to provide our body with this important vitamin that can be done by adding sufficient amounts of food sources of Vitamin B4 to our daily diet.

 

Vitamin B4(Adenine) is also considered a purine derivative, which is a necessary element for proper protein synthesis and related chemical processes. Besides, vitamin B4 is an key component of DNA and RNA, nucleic acids that carry very valuable and unique genetic information about everyone of us. Along with proteins, these acids are principal for normal development and functioning of any human body or other living organisms and all forms of life on earth.

Adenine is the one of the nitrogenous bases of DNA also helpful in making code for DNA and is very important component of the DNA. It is a purine. Adenine forms a bond with thiamine in the DNA.  This vitamin B4 also forms a part of adenosine triphosphate (ATP)which is important in the transport of energy between many reactions and also forms adenosine which plays an important role in various biochemical processes. It enables the change of phosphate group which then provide energy which is very necessary for various cellular reactions and for cells’ life.

Also, adenine plays a very important role in biochemical processes linked to cell metabolism. In combination with sugar ribose, adenine forms such compound as adenosine, which further participates in formation of adenosine triphosphate, adenosine diphosphate, and adenosine monophosphate. These nucleotides are supposed to take part in the propagation of many hormonal stimuli. Vitamin B4 can be found as an element of various coenzymes in human body, which combine with vitamins to produce good amounts of energy. As it was said before, it is one of the main benefits of Vitamin B4.

https://blissreturne...everyone-of-us/

 

 


Edited by Phoebus, 29 August 2018 - 01:09 PM.

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#2 Phoebus

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Posted 29 August 2018 - 01:10 PM

https://www.amazon.c...L70_&dpSrc=srch



#3 stefan_001

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Posted 30 August 2018 - 06:29 AM

I think understanding whether there is a deficit is important for this one before starting supplementation:

 

The Effects of Dietary Food Fortified with Vitamin B4 on Lipid Profiles in Serum and Liver Tissue

http://journal.ui.ac...viewArticle/639

ratstudy:

In conclusion: Dietary food fortified with vitamin B4 induces hypertriglyceridemia and liver PL level.

 


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#4 Phoebus

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Posted 30 August 2018 - 01:01 PM

I think understanding whether there is a deficit is important for this one before starting supplementation:

 

The Effects of Dietary Food Fortified with Vitamin B4 on Lipid Profiles in Serum and Liver Tissue

http://journal.ui.ac...viewArticle/639

ratstudy:

In conclusion: Dietary food fortified with vitamin B4 induces hypertriglyceridemia and liver PL level.

 

 

 

Thank you , the problem is that the term 'vitamin B4' could refer to adenine, choline, or carnitine. so in this study which is it? hard to say as full study is not easily available. 

 

this study shows the opposite. Fatty liver disease is reversed by dietary adenine in rats. 

 

 

 

 

 

https://www.semantic...0c5ebb23b4395a4

An Orotic Acid-induced , Adenine-reversed Inhibition of Hepatic Lipoprotein Secretion in the Rat
  • H. G. WINDMUELLER
  • Published 2003
The induction of a severe fatty liver in rats by the addition of erotic acid to their purified diets was first reported by Standerfer and Handler (1). Creasey, Hankin, and Handschumacher (2) found that the liver fat was largely triglyceride and observed that its accumulation was both prevented and reversed by supplementing the erotic acid diets further with adenine (3). Marked alterations in the concentration of various acid-soluble nucleotides of liver also result from the ingestion of erotic acid, with a 400 70 elevation of uridine nucleotides and a 50 70 depression in adenine nucleotides being the most prominent (4). The mechanism by which dietary erotic acid and adenine alter lipid metabolism is unknown and is the subject of this investigation. Several experimental approaches were used and the following parameters were studied: (a) the effect of altering dietary protein and fat levels on the action of erotic acid; (b) the fatty acid composition of accumulated liver lipids of rats fed a fat-free erotic acid diet; © the effect of erotic acid on lipogenesis and fat transport as measured by the incorporation in viva of tritium from labeled body water into the fatty acids of various body compartments; (d) the effect of dietary erotic acid and adenine on the lipid, glucose, and protein content of plasma; and (e) the effect of dietary erotic acid on the hyperlipemia induced by the intravenous injection of a nonionic surface-active agent. From these studies it is concluded that the fatty liver induced by erotic acid results from a severe inhibition of hepatic lipoprotein secretion, and that the addition of adenine to the diet rapidly reverses this inhibition. LESS

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#5 Phoebus

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Posted 30 August 2018 - 01:12 PM

this study shows dietary adenine boosts the immune response to Staph A. infection 

 

https://onlinelibrar...607186010002169

 

this study shows dietary adenine slows overal growth rates in rats 

 

https://academic.oup...6/3/435/4763583

 

this next study shows dietary adenine shortens lifespans of worms 

 

 

 

https://www.scienced...550413112004974 Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies  
Summary
 

A common thread among conserved life span regulators lies within intertwined roles in metabolism and energy homeostasis. We show that heterozygous mutations of AMP biosynthetic enzymes extend Drosophila life span. The life span benefit of these mutations depends upon increased AMP:ATP and ADP:ATP ratios and adenosine monophosphate-activated protein kinase (AMPK). Transgenic expression of AMPK in adult fat body or adult muscle, key metabolic tissues, extended life span, while AMPK RNAi reduced life span. Supplementing adenine, a substrate for AMP biosynthesis, to the diet of long-lived AMP biosynthesis mutants reversed life span extension. Remarkably, this simple change in diet also blocked the prolongevity effects of dietary restriction. These data establish AMP biosynthesis, adenosine nucleotide ratios, and AMPK as determinants of adult life span; provide a mechanistic link between cellular anabolism and energy sensing pathways; and indicate that dietary adenine manipulations might alter metabolism to influence animal life span.

 


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