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11.➔Don’t issue population-wide guidelines based on weak data
Experts developing the guidelines have, in many cases, issued recommendations based on weak, observational data, while ignoring relevant clinical trial data to the contrary. The guidelines should be based on a complete, comprehensive review of the most rigorous (randomized, controlled clinical trial) data available, and on subjects for which this data is lacking, the guidelines should either issue “weak recommendations” or else remain silent.