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Post your opinions on niacin.

niacin

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28 replies to this topic

#1 KBAnthis

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Posted 02 September 2018 - 01:38 AM


Well lets hear any opinions on niacin. I ordered some to try to get free shipping and have enjoyed it immensely. The euphoria is nice. I don't know if I should order more. I have taken it daily for over a month now. What are you opinions on niacin? 


Edited by KBAnthis, 02 September 2018 - 01:40 AM.


#2 Galaxyshock

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Posted 02 September 2018 - 07:10 AM

Which form of niacin do you take?

 

I find niacinamide anxiolytic as it increases tryptophan intake to brain and also has a GABAergic mechanism if I remember correctly.

 

The flushing kind of niacin makes me feel a bit uncomfortable but then again it's kinda relaxing.



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#3 Turnbuckle

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Posted 02 September 2018 - 10:01 AM

If you want random opinions, you can find thousands at Amazon. Just pick the niacin product with the most reviews. 


  • Agree x 1

#4 Painkillerrr

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Posted 02 September 2018 - 05:01 PM

niacinamide gives me brainfog and headache.



#5 KBAnthis

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Posted 02 September 2018 - 05:11 PM

I was using Nicotinic Acid. I don't think I will reorder as of now since the b-complex I take includes niacinamide. 



#6 Painkillerrr

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Posted 02 September 2018 - 05:31 PM

b-complex usually have low dose of it (10-20mg), for anxiolytic effect you need like 500mg to 2-3g

 

Turnbuckle, do you think i should try using it for more days to see if the brainfog/fatigue stops?

 

i have a low blood pressure so maybe thats why i have such a bad effect from it

 

https://www.nature.c...467-018-03421-7


Edited by Painkillerrr, 02 September 2018 - 05:39 PM.


#7 joelcairo

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Posted 02 September 2018 - 06:36 PM

If you're feeling euphoria from taking niacin then keep taking it I guess. I've experienced the niacin "flush", but never euphoria from that or any supplement.


Edited by joelcairo, 02 September 2018 - 07:10 PM.


#8 John250

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Posted 02 September 2018 - 07:54 PM

Regular niacin flushes me and makes me itchy unless it’s a low-dose
I felt nothing from niacinamide
I felt nothing from TruNiagen
  • Agree x 1

#9 Dorian Grey

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Posted 02 September 2018 - 10:06 PM

High dose, & particularly time release niacin has been associated with liver issues...  

 

https://livertox.nih.gov/Niacin.htm

 

"Niacin can cause mild-to-moderate serum aminotransferase elevations and high doses and certain formulations of niacin have been linked to clinically apparent, acute liver injury which can be severe as well as fatal"

 

-----------------

 

Probably best to avoid mixing this with alcohol.  



#10 Turnbuckle

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Posted 03 September 2018 - 09:43 AM

I used niacin for twenty years, so here are some pointers--

 

The flush is initially much greater, then tolerance sets in. Subsequent flushes are a bit unpredictable, but you can get rid of them faster by drinking lots of water.

 

Niacin raises HCl production in the stomach, so if you're taking large doses every day, consider taking an HCl blocker like Pepcid.

 

The liver damage from "certain formulations of niacin" referred to above were from time release formulations. As with many other supplements, intermittent dosing is best as constant dosing may have negative effects. I stopped two decades ago when I heard about the liver damage thing, though I didn't have any signs of it even after using it for twenty years. I had always looked younger than people my age, but after stopping I began to age rapidly--or so it seemed to me. This was apparently from the more rapidly aging of mitochondria, with prescribed statin use a coup de grace. A couple of years ago I discovered how to use nicotinamide and ribose to weed out damaged mitochondria. Nicotinamide works better than niacin for this purpose as the half-life of nicotinamide is much longer and nicotinamide is chemically closer to NAD. The basic idea is to fission mitochondria with high NAD+ levels produced by nicotinamide, which sets the cellular QC machinery running. The following is from my profile page--

 

Manipulating mitochondrial dynamics 

 
One of the primary causes of ageing is the build-up of defective mitochondria. These are the powerhouses of the cell, and each cell has about a thousand. This protocol takes the natural process of mitochondrial fission and fusion and ramps it up to create a heightened period of fission/mitophagy where bad mitochondrial DNA is identified and removed, and then a heightened period of fusion/biogenesis where new mitochondrial DNA is generated. By cycling through fission and fusion according to the protocol, the population of mitochondria can be restored to a more youthful condition.
 
See Post #977 for a protocol (I went through a number them over six months).
 

 

 
 

 

The protocols in that thread are for older people with substantial damaged mitochondria (damaged mtDNA, actually), and thus those with healthy mitochondria won't notice much of anything. But if you have a lot as I did, you will get dramatic effects. In any case, if you get euphoric feelings from niacin--and there is no question that you can--you will not get that from nicotinamide. 

 

­


Edited by Turnbuckle, 03 September 2018 - 09:44 AM.

  • Well Written x 1
  • Good Point x 1

#11 Painkillerrr

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Posted 03 September 2018 - 05:24 PM

but is there a way to avoid fatigue/tiredness when taking it?



#12 Rocket

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Posted 04 September 2018 - 12:31 AM

but is there a way to avoid fatigue/tiredness when taking it?



???? People get tired from niacin????

I am a long term user of a niacin. I cycle it. Tudca alleviated any liver issues from high doses.

No flushing after long term use.

Is good for lipids. I have seen it in pre and post blood work.

It cleared up some minor skin issues.

It is bad for sirt1, hence I cycle it.

#13 Painkillerrr

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Posted 04 September 2018 - 09:48 AM


???? People get tired from niacin????

I am a long term user of a niacin. I cycle it. Tudca alleviated any liver issues from high doses.

No flushing after long term use.

Is good for lipids. I have seen it in pre and post blood work.

It cleared up some minor skin issues.

It is bad for sirt1, hence I cycle it.


I get tiredness from nicotinamide not niacin (never tried it)

#14 Turnbuckle

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Posted 04 September 2018 - 11:05 AM

 

i have a low blood pressure so maybe thats why i have such a bad effect from [nicotinamide]

 

 

 

Very likely. A year ago my systolic BP was 180 without meds, and when I started the mito protocol with nicotinamide and ribose (N+R), it dropped below 100. So if you are hypotensive to begin with, I imagine you would have a hard time getting out of bed. 

 

This is a temporary thing, as after I got rid of all the bad mitochondria, N+R had little effect. And if nicotinamide drops your BP too far, you can reverse that with stearic acid. Stearic acid eliminates the mito fission state where bad mitochondria are dumped into a lysosomal bin. Niacin has much less impact on mitochondria, and thus you may not see the BP effect.



#15 BieraK

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Posted 28 September 2018 - 05:04 AM

I did a week experiment with niacin.

3 doses a day, sometimes coinciding with food. I stacked it with Niacinamide and Ribose.

The flush has notorious anti-inflammatory effect on me.

Hair looks better

Increased blood flow

It eliminates hangover

It reduced neck aches and some pains

 

Only thing concerns me about Niacin are its effect of reduced insulin sensivity, according to studies it produces insulin resistance. So I don't know what is best dosage schedule for it

 

-One dose a day before going to bed. By doing this the FFA rebound and diminished glucose on the body could lead to a mild ketosis and a reduced probabilities of becoming insulin resistant, since typically I have at least two hours of not eating before going to bed this gives me 10 hours of "no food" so with Niacin I release glucose and then I use the rest of time while sleeping for getting the benefits on the rebound in FFA

 

-Small doses of 300 mg x 3 a day with food, and ideally with Niacinamide and Ribose. Here I have my doubts, perhaps this carry a risk of insulin resistance.



#16 kurdishfella

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Posted 08 June 2020 - 02:07 PM

which is better for increasing nad, nadp - niacin (flush) or niacinamide?

 

 

Actually I periodically take niacinamide now. My main source from it is multivitamin

You know isolation of a vitamin.... it doesnt really work well that way. Co factors are required. If not the nutrients in the body get exhausted that could cause other issues. Or builds up at the wrong place etc.

Not sure how old you are. But best supplement I have taken these days is coq10/ubiquinol (paired with multivitamin)

It powers the heart better than anything. From there extends to power the mitochondria for the rest of the body

You will feel a flush from it also. A younger working heart will also assist with NAD, repair etc.

Ramping up NAD but using an older or inefficient heart... its like going against the current. Q: Hey I saw your comment regarding niacin 4 months ago: ''Take niacinamide at 100mg and not niacin if you want to activate nad''

I want to increase my NAD and NADP levels, and I was wondering why the non flush niacin would be better for activating nad as you say? Right now I'm using the nicotnic acid which causes flush but if the other form of niacin is better I will gladly switch.

 

 

 


Edited by kurdishfella, 08 June 2020 - 02:11 PM.


#17 Oakman

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Posted 08 June 2020 - 05:10 PM

I recently ran across videos (starting Dec 2019) from this young doctor, Brad Stanfield, from New Zealand, who had some interesting thoughts on NA, NMN, and NAM. He looks a bit 'deer in the headlights' in his videos, but what he says, how he explains things, makes more sense to me than, for instance, the ramblings of Dr. Sinclair.

 

Esp. noteable, he discusses using niacin and a study that shows its ability to raise NAD levels in muscle, something NMN and NR are not capable of doing.

 

NAD+ is a redox-active metabolite, the depletion of which has been proposed to promote aging and degenerative diseases in rodents. However, whether NAD+ depletion occurs in patients with degenerative disorders and whether NAD+ repletion improves their symptoms has remained open. Here, we report systemic NAD+ deficiency in adult-onset mitochondrial myopathy patients. We administered an increasing dose of NAD+ - booster niacin, a vitamin B3 form (to 750–1,000 mg/day; clinicaltrials.gov NCT03973203) for patients and their matched controls for 10 or 4 months, respectively. Blood NAD+ increased in all subjects, up to 8-fold, and muscle NAD+ of patients reached the level of their controls. Some patients showed anemia tendency, while muscle strength and mitochondrial biogenesis increased in all subjects. In patients, muscle metabolome shifted toward controls and liver fat decreased even 50%. Our evidence indicates that blood analysis is useful in identifying NAD+ deficiency and points niacin to be an efficient NAD+ booster for treating mitochondrial myopathy.

 

https://www.cell.com...4131(20)30190-X

 

---

 

NMN vs Nicotinamide & Niacin | How To Save Money April 2020  https://www.youtube....h?v=TViYsaUM8uk

NIACIN & NICOTINAMIDE vs Expensive NR & NMN?  https://www.youtube....h?v=6BkduBDpjvk

NIACIN vs NMN | Important May 2020 Research  https://www.youtube....y5eK02s0&t=610s


Edited by Oakman, 08 June 2020 - 05:12 PM.


#18 BieraK

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Posted 13 June 2020 - 08:37 AM

Niacin flush gives me insanely workouts.
Problem is the meals for inducing Muscle protein synthesis. You only can eat in the 2 hour window after taking niacin. Eating carbs and protein without taking another niacin dose when the body is under the Free fatty acid rebound is playing with fire.
I did that error last week and felt horrible, I even wake up next day with a gray hair in my eyebrows, for a 31 men thats scary.

#19 ironfistx

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Posted 15 June 2020 - 02:24 AM

I used niacin for twenty years, so here are some pointers--

 

The flush is initially much greater, then tolerance sets in. Subsequent flushes are a bit unpredictable, but you can get rid of them faster by drinking lots of water.

 

Niacin raises HCl production in the stomach, so if you're taking large doses every day, consider taking an HCl blocker like Pepcid.


­

 

Interesting you mention this.  When I took Niacin once I got a 16 hour flush and then got GERD shortly thereafter which has not gone away since.



#20 kurdishfella

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Posted 12 May 2021 - 11:41 AM

Niacin is the only b vitamin that doesn't give me energy (immediate?). it only digests food. Maybe cause im not deficient or it needs other vitamins or a lot of nad energy to work longterm.

Edited by kurdishfella, 12 May 2021 - 11:59 AM.


#21 kurdishfella

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Posted 12 May 2021 - 01:37 PM

also one time i took high dose niacin and i got the flush like 12 hours later. usually it would take 1 hour or so. why the delay? and one time I took like 1000mg of Nac got horrible hearburn but then Took 10 gram and nothing happened. Maybe my body defense mechanism realized it was too much so it didnt absorb it or break it down so i didnt die or somth

Edited by kurdishfella, 12 May 2021 - 01:37 PM.


#22 Rocket

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Posted 13 May 2021 - 01:11 AM

I love REAL niacin. I was running it for years at idk maybe 3 to 5g daily. Great for the body and great for lipids.

#23 KBAnthis

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Posted 13 May 2021 - 03:25 AM

I will rarely take niacin these days outside of a b-complex. Lately I have been using California Gold Vitamin B-Complex and will sprinkle a portion of a capsule of it into my daily smoothie. When using the website cronometer, I normally will reach my RDAs of B-Vitamins. I have been taking Desmodium Adscndens, or Desmodium Molliculum to help widen my bronchial tubes which acts similar to niacin in that it causes the capillaries to expand and increases blood flow. Sometimes monthly, sometimes weekly I will take up to 500mg with a b-complex. I do enjoy it from time to time still and have some fond memories taking it. After reading what Oakman wrote, I just took 1 gram with a b-complex. I recall reading that before, after time, I moved it back to 500 mg. I will see how I feel the next couple days. 


Edited by KBAnthis, 13 May 2021 - 03:48 AM.


#24 mikeinnaples

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Posted 01 June 2021 - 01:06 PM

 it only digests food.

 

Huh? It doesnt digest anything, lol.



#25 mbdrinker

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Posted 23 November 2022 - 06:58 PM

I have stopped taking it because it gives enormous adrenaline boost with heart ache and headache. Switched to selegiline for its less ache and more euphoria.

#26 kurdishfella

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Posted 23 November 2022 - 07:22 PM

I would stay away from B vitamins.


  • Pointless, Timewasting x 2

#27 mbdrinker

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Posted 24 November 2022 - 02:59 PM

Why?



#28 mbdrinker

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Posted 30 November 2022 - 07:19 PM

Continued taking it. Headache has diminished to minor but energy stays high so that i can do work about the house without cursing all the time. As to energy levels it derinitely beats dophamine boosters for middle aged people. Also i bear cold weather better and my hands are warm all the time. Miraculous thing. To get accustomed take 5mg per day first for a week or so. Than i could take 3 such doses in 3 intakes even with coffee with no flushes or headache or pulse increase. Serotonin boosters of course are more pleasant but make you impotent. Can be taken with 1.25 mg of selegiline once per  3 days with no adverse effects.



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#29 mbdrinker

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Posted 19 January 2023 - 01:37 PM

With 50mg per day it has cured deformities on foot fingers that have been for about 6 years. So it works unlike nsaids



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