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Klotho enhanced lifespan by 20-30% and enhanced cognition

klotho nootropic life-span

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#1 Painkillerrr

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Posted 05 September 2018 - 08:14 AM


Hello, this is a review of klotho functions:

https://www.research...ng_Protein#pf14

Here one of the study using a klotho fragment as a long lasting nootropic (weeks)

https://www.cell.com...1247(17)30990-7

Here mice with overexpression of klotho show cognitive improvement even after 6 months (in human term 6 would be decades): https://www.nature.c...pdf?origin=ppub

And all study claimed enhanced cognition in both young and aged mice and in one study they claimed even some anxiolytic effects.

In human klotho variance can "boost" up to 6 iq point

I have no idea why 0 clinical study has been done on human at this point, there is a company called klotho therepeutics which claim they will enter in clinical in 2 years.

Well anyone for a group buy of a "klotho fragment"?

Edited by Painkillerrr, 05 September 2018 - 08:15 AM.


#2 theobromananda

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Posted 05 September 2018 - 12:48 PM

Smoking upregulates klotho. If it does not kill you, it will extend your lifespan and make you sharp - my grandmother is 90, smoking like a chimney and mentally sharp.


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#3 tunt01

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Posted 02 April 2019 - 05:04 PM

NY Times:  One day there by a drug to turbocharge the brain.  Who should get it?

 

See also:  personal gene therapy



#4 BlueCloud

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Posted 08 April 2019 - 12:45 PM

Smoking upregulates klotho. If it does not kill you, it will extend your lifespan and make you sharp - my grandmother is 90, smoking like a chimney and mentally sharp.

 

I can't find any sources for that. The only thing I found that may enhance production of klotho is Vitamin D : https://www.ajkd.org...0288-0/abstract



#5 JamesPaul

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Posted 23 December 2020 - 03:15 AM

The site whose URL is below lists 50 ways to increase Klotho, including diet, lifestyle, supplements, probiotics, hormones, drugs/chemicals, and pathways, with references.  The probiotics are specific strains of bacteria, not just any old strain.

 

https://mybiohack.co...tamin?rq=Klotho

 

Also you can get genetic therapy to increase Klotho if you have sufficiently deep pockets.

 

https://www.integrat...th-systems.com/



#6 moomoo

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Posted 24 December 2020 - 12:40 PM

 

 

Factors That Increase Klotho Levels

The role of Klotho protein in human health and disease is not fully clear. Improving your Klotho levels won’t necessarily cause health improvement of any kind.

The following is a list of factors and complementary approaches that may increase Klotho levels. Additional large-scale studies are needed before making any conclusions. Remember to talk to your doctor before making any major changes to your day-to-day routine.

  • Exercise – in both humans and mice. Klotho only increases post-exercise in people who completed a 16-week training program, with younger people having a bigger increase than older people. Based on mouse studies, it’s believed that muscle injury and new muscle cells secrete Klotho [7].
  • Vitamin D (Calcitriol) increases Klotho. However, Vitamin D supplements apparently don’t work in humans to increase Klotho, even when calcitriol goes up. In dialysis patients, vitamin D supplements actually decrease Klotho [23, 24, 25, 26].
  • Insulin increases klotho. This is one downside to a really low carb diet [27].
  • PPARgamma activators [12, 28].
  • Activated charcoal by binding to a toxin that decreases klotho (Indoxyl sulfate) [29].
  • Probiotics such as Acidophilus + L Lactis in aging mice [30].
  • Cordyceps reverses the Angiotensin II decrease in klotho [31].
  • Gentian root extract – might simply stabilize some part of the process after its production [32].
  • ACE inhibitors
  • Statins (HMG -CoA reductase inhibitors) – might simply stabilize some part of the process after its production [33, 34, 32].

 

and yes, smoking:


Edited by moomoo, 24 December 2020 - 12:43 PM.

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#7 moomoo

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Posted 24 December 2020 - 12:58 PM

I can't find any sources for that. The only thing I found that may enhance production of klotho is Vitamin D : https://www.ajkd.org...0288-0/abstract

 

I wish it were that simple.

 

  • Vitamin D (Calcitriol) increases Klotho. However, Vitamin D supplements apparently don’t work in humans to increase Klotho, even when calcitriol goes up. In dialysis patients, vitamin D supplements actually decrease Klotho [1, 2, 3, 4].
  1. https://www.nature.c...ki2012338a.html
  2. https://www.ncbi.nlm...pubmed/22932118
  3. https://www.ncbi.nlm...pubmed/23988791
  4. https://www.ncbi.nlm...pubmed/23673970


#8 gamesguru

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Posted 25 December 2020 - 03:02 PM

Smoking doesn't have to mean smoking. Tobacco can be used in any herbal vape.

Not saying it's tasty or mentally innocuous, but nicotine can at least be consumed in a natural, non-pyrolytic manner!
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#9 adamh

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Posted 25 December 2020 - 06:43 PM

Tobacco is nasty in all forms. Those who only chew get greater incidence of mouth cancer and they aren't even heating it. Nicotine is used as a bug poison, some places they just soak tobacco in water and spray the plants. It kills the bugs but then they have to eat them 

 


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#10 Neurocryo

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Posted 27 December 2020 - 03:02 AM

The KLVS haplotype in heterozygosity is best while people homozygous for the mutant better klotho are no better off than WT klotho.  Something weird is going on with this heterozygous advantage where perhaps a mild dose of a variant protein is better than more or none.



#11 Soalian

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Posted 30 December 2020 - 09:58 PM

So I'm still on the lookout for a source for PEP-1192, to no success so far.



#12 sub7

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Posted 19 January 2021 - 06:56 PM

If one were to inject klotho -actual klotho, not a fragment or variant or agonist of it- what is a proper daily dose?



#13 Daniel Cooper

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Posted 20 January 2021 - 09:31 PM

What is AST-120 "an oral carbon adsorbent".  How is it different than charcoal?  I couldn't find much on it.



#14 Neurocryo

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Posted 29 March 2021 - 01:36 AM

If one were to inject klotho -actual klotho, not a fragment or variant or agonist of it- what is a proper daily dose?

I wouldn’t think to try that until more research is completed.  It’s weird that it’s best for a person to have only 1 copy of the good allele instead of none or two.  That’s got to be some strange biological phenomena if it’s not simply an intermediate dosage is best.

 

if you want to take your chances I would try and find some data in human blood or tissue samples as to levels of klotho protein detected in WT, Het, and Homo for KLVS haplotype.  Then I would inject purified protein and take blood tests on myself to see that I am achieving a dose near the het level.

 

Medium term there will probably be a gene therapy where WT people can insert a copy of KLVS allele, one copy is the key and hit that het dose stably.



#15 gintrux

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Posted 09 April 2021 - 09:27 AM

https://discord.gg/6JFmppErDs

we talked about it. There is a gene therapy company doing klotho gene therapy for ~80k usd. Injecting actual klotho could be interesting, hopefully someone can find a vendor first.



#16 drtom

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Posted 01 May 2021 - 10:17 AM

https://discord.gg/6JFmppErDs

we talked about it. There is a gene therapy company doing klotho gene therapy for ~80k usd. Injecting actual klotho could be interesting, hopefully someone can find a vendor first.

 

There is at least one vendor: Buckylabs in the USA.

 

Disclosure: I have no affiliation with Bucklabs.


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#17 ortcloud

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Posted 14 November 2021 - 03:17 PM

If one were to inject klotho -actual klotho, not a fragment or variant or agonist of it- what is a proper daily dose?

 

I take .5pg based on dosing protocol from Steve Perry.

 

The vial came in 25ug so you have to dilute it by factor of 50 million, which was not easy.

 

Overall I really like it, very interesting cognitive boost and it calms my adhd and gives me great focus like a nootropic.


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#18 rodentman

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Posted 14 November 2021 - 11:10 PM

I take .5pg based on dosing protocol from Steve Perry.

 

The vial came in 25ug so you have to dilute it by factor of 50 million, which was not easy.

 

Overall I really like it, very interesting cognitive boost and it calms my adhd and gives me great focus like a nootropic.

 

I am also considering purchasing it, probably from Buckylabs, were I purchased the GDF11.   That's quite a dillution factor.  .5pg or 500 femptograms?   yowzers.  How long did it help before it improved your cognition?



#19 ortcloud

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Posted 14 November 2021 - 11:18 PM

 How long did it help before it improved your cognition?

 

It was pretty fast, I started out the first few days at half dose just in case to see how my body would react but I would say I could tell on day 2 for sure.


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#20 rodentman

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Posted 14 November 2021 - 11:28 PM

It was pretty fast, I started out the first few days at half dose just in case to see how my body would react but I would say I could tell on day 2 for sure.

 

I think I'll order it today.  btw, there are some places that measure kotho levels in the blood/plasma.  I'm not sure how valuable that would be.  

This place measures it by itself, or part of their Profile AgeCheck package:

 

https://www.lab4more...4_EN_210803.pdf


Edited by rodentman, 14 November 2021 - 11:30 PM.

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#21 ortcloud

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Posted 15 November 2021 - 12:25 AM

I think I'll order it today.  btw, there are some places that measure kotho levels in the blood/plasma.  I'm not sure how valuable that would be.  

This place measures it by itself, or part of their Profile AgeCheck package:

 

https://www.lab4more...4_EN_210803.pdf

 

Thats very interesting. Lots of good stuff on that menu. Is this in Germany?

 

I knew that RED labs would test it for you as a special test that wasnt on their menu for immortalis customers.

 

http://blog.redlabor...immortalis.html



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#22 rodentman

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Posted 15 November 2021 - 01:22 AM

Thats very interesting. Lots of good stuff on that menu. Is this in Germany?

 

I knew that RED labs would test it for you as a special test that wasnt on their menu for immortalis customers.

 

http://blog.redlabor...immortalis.html

 

Yeah, its in Germany.  You may actually be able to include GDF11 as a custom order.  They used to offer it.
 
Just email them to see what they offer.  They will specify what type of test kit they will want you to use, then just send it on Monday or Tuesday using the Fed-ex 48 hour non-infectious human blood pack.  

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