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STUDY CLAIMING ROBUST IMPROVMENT IN PROBLEM SOLVING SKILLS IN MICE

problem solving memory nootropic nootropics

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#1 Painkillerrr

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Posted 10 September 2018 - 10:34 AM


Hello, i have found a interesting  2016 study where a single gene has been knockdown rising the mean right answer of a problem solving test (puzzle box) from 20% to almost 50%.

 

i dont know what would correspond such improvement for human standard, but maybe 15-30 (1 to 2 standard deviation) iq point?

 

the same gene knockdown in another study enhanced memory (ltp).

 

 

enhanced problem solving + lower anxiety: https://sci-hub.tw/h...012496616040098

 

enhanced memory: https://www.cell.com...6273(03)00334-9

 

the gene is SLC8A2 encoding: Na+/Ca2+ exchanger (NCX2)

 

some study with a similar compound acting on the same "pump" lead to reduced risk of dementia: https://www.ncbi.nlm...les/PMC4923720/

 

fk506 inhibits other ncxs and does not cause reduction of the protein: https://books.google...06 NCX2&f=false

 

psc833 inhibits other protein causing damage

 

the problems are:

 

-inhibition nxc3 lead to memory impairment.

 

-nxc1,3 are present in other part of the body so inhibition could cause other problems

 

-inhibition of NCKX leads to memory impairment.

 

 

SOLUTION:

 

-find a selective inhibition of ncx2

 

-find a selective down regulator of its gene.

 

 

problems anyway:

 

im not sure if inhibition in a adult would have the same nice effects of knocking down the gene

 

 

 


Edited by Painkillerrr, 10 September 2018 - 10:45 AM.






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