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problem solving memory nootropic nootropics

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#1 Painkillerrr

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Posted 10 September 2018 - 10:34 AM

Hello, i have found a interesting  2016 study where a single gene has been knockdown rising the mean right answer of a problem solving test (puzzle box) from 20% to almost 50%.


i dont know what would correspond such improvement for human standard, but maybe 15-30 (1 to 2 standard deviation) iq point?


the same gene knockdown in another study enhanced memory (ltp).



enhanced problem solving + lower anxiety: https://sci-hub.tw/h...012496616040098


enhanced memory: https://www.cell.com...6273(03)00334-9


the gene is SLC8A2 encoding: Na+/Ca2+ exchanger (NCX2)


some study with a similar compound acting on the same "pump" lead to reduced risk of dementia: https://www.ncbi.nlm...les/PMC4923720/


fk506 inhibits other ncxs and does not cause reduction of the protein: https://books.google...06 NCX2&f=false


psc833 inhibits other protein causing damage


the problems are:


-inhibition nxc3 lead to memory impairment.


-nxc1,3 are present in other part of the body so inhibition could cause other problems


-inhibition of NCKX leads to memory impairment.





-find a selective inhibition of ncx2


-find a selective down regulator of its gene.



problems anyway:


im not sure if inhibition in a adult would have the same nice effects of knocking down the gene




Edited by Painkillerrr, 10 September 2018 - 10:45 AM.

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