This topic is lockedLife Sci. 2018 Sep 6. pii: S0024-3205(18)30560-5. doi: 10.1016/j.lfs.2018.09.015. [Epub ahead of print]
Nicotinamide riboside induces a thermogenic response in lean mice.
Crisol BM1, Veiga CB2, Lenhare L3, Braga RR1, Silva VRR1, da Silva ASR4, Cintra DE2, Moura LP5, Pauli JR5, Ropelle ER6.
... Male C57BL/67 mice were supplement with NR (400 mg/Kg/day) during 5 weeks. ...
Transcriptomic analysis revealed that genes involved in NAD+ synthesis (Nampt and Nmnat1) in the BAT were negatively correlated with body weight and fat mass [in several isogenic strains of BXD mice]. The heat map showed a strong positive correlation between Nampt and Ucp1 mRNA in BAT and body temperature in several strains of BXD lean mice. The experimental approaches demonstrated that oral NR supplementation reduced the abdominal visceral fat depots, with discrete impact on oxygen consumption in C57BL/6J mice. Interestingly, NR significantly increased the body temperature, and this phenomenon was accompanied by high levels of UCP1 protein content and Pgc1α mRNA in BAT.
PMID: 30195617
DOI: 10.1016/j.lfs.2018.09.015
I'm not sure whether I buy this or not ... There have certainly been reports of greater thermogenesis in models of obesity. Sinclair reported that mice with an extra NAMPT transgene "exhibited similar increases in body weight and fat mass percentage when fed [obesity-inducing high-fat/high-sugar diet] or [regular mouse chow]" as "wild-type" C57BL/6J mice (PMID 29146412). Imai's long-term NMN mouse study did report that "NMN administration significantly and dosedependently suppressed age-associated body weight gain ... normalized to control mice were 4% and 9% in 100 and 300 mg/kg/day groups, respectively," but this was in association with greater ambulatory activity in the low-dose group (but no change in the high-dose group), an altered respiratory quotient, and no change in body temperature. And there was no effect of NR on body weight in either young (1 months old) or aged (22-24 months old) C57BL/6J mice administered 400 mg/kg/d NR for 6 weeks in the NR lifespan study — a similar duration as this.
