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Theory behind Modafinil+ Amphetamine

modafinil adderall amphetamine

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#1 John250

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Posted 12 September 2018 - 05:37 PM


Correct me if I am wrong on this theory.

Besides Modafinils effects on other neurotransmitters lets just talk about dopamine. Modafinil is a dopamine reuptake inhibitor meaning when the brain normally boosts dopamine it will then block an excess of dopamine. So Modafinil interferes with this blockade allowing more natural dopamine to be present.

Amphetamine will basically push dopamine out of the synapse.

So if you take Modafinil first and your brain naturally has more dopamine available wouldn’t taking an amphetamine push even more dopamine out so you get a better effect?

So perhaps the best method of action to get the most out of dopamine would be to take Modafinil in the morning, then amphetamine a few hours later and perhaps some precursors at night like tyrosine?

#2 prunk

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Posted 13 September 2018 - 10:09 AM

They synergize almost too well - a caution is more than adviced! I had a prescription for both a while ago, and after a month using both simultaneously, I went to a mild psychosis. Lack of sleep was probably one major contributing factor.

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#3 Galaxyshock

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Posted 13 September 2018 - 10:32 AM

Modafinil is complicated as it seems to avoid being addictive despite the DRI mechanism. When combined with cocaine, modafinil actually blunts the effects of it.

 

Modafinil also works through glutamate, histamine and orexin which probably make it such a clean eugeroic.



#4 jack black

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Posted 13 September 2018 - 01:15 PM

if it take a small dose of mod and coffee in one day, huge headache from too much stimulation. Mod+amph would probably give me a stroke. Never tried it though.

don't forget amphetamins are neurotoxic.


Edited by jack black, 13 September 2018 - 01:17 PM.


#5 John250

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Posted 13 September 2018 - 07:53 PM

There is definitely some sort of cross tolerance if you take Modafinil after amphetamines. Yesterday I took my normal Vyvanse in the morning and a few hours later I took a low-dose 100mg Modafinil and not only did I get no extra energy but I felt brain fog and spacey all day. I might play around with it one more time and try Modafinil first to see if that makes a difference.

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#6 jack black

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Posted 13 September 2018 - 09:13 PM

this is what I mean, too much stimulation can give you brain fog. remember the inverted bathtub shape of dopamine receptors response.







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