What would the benefit be of one compared to the other? SNDRI will increase serotonin, dopamine and NE by inhibiting uptake and an maoi would increase all 3 as well by inhibiting monoamine oxidase. So what is the main difference? Which is safer? And why do you rarely see psychiatrists prescribing Maoi’s but They prescribe SNDRI’s all day long.
#1
Posted 30 September 2018 - 08:47 PM
What would the benefit be of one compared to the other? SNDRI will increase serotonin, dopamine and NE by inhibiting uptake and an maoi would increase all 3 as well by inhibiting monoamine oxidase. So what is the main difference? Which is safer? And why do you rarely see psychiatrists prescribing Maoi’s but They prescribe SNDRI’s all day long.
#2
Posted 08 October 2018 - 03:55 PM
Maois do not just raise the level of the 3 main neurostransmitters, there are a lot of other secondary neurotransmitters that are affected to, like PEA. Then the non-selective maois that get used have some other unique pharmacological effects, which are also part of their working. You do get some kind of synergy effect from that all that I guess, because I have tried the effects of a SDNRI cocktail 2 times and tranylcypromine feels way more effective to me, especially over time.
Edited by Junipersun, 08 October 2018 - 03:55 PM.
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