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Iron...take it?

iron

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#31 experimenting

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Posted 15 October 2018 - 01:00 AM

Agree; once the brain is loaded up with iron, bloodletting ins't going to provide any real benefit, & even herbal chelators may not have much effect. Hopefully the medical chelators will show promise at salvaging those with early stage Alzheimer's.

An ounce of prevention worth a pound of cure! Maintain good iron homeostasis throughout your life, & hopefully your brain will last as long as your body does.

Keep ferritin out of triple digits and chelate the small amount of free/labile iron with good nutrition (or supps). You'll minimize Fenton reactions and generation of hydroxyl radicals (the most destructive force in the body at the cellular level).


Is protein bound iron (ie IPS) the "same" as heme iron? They are both bound to protein molecules though of different kinds. Does this make them equally safe? My n=1 trial is having great results on 15mg equivalent IPS; no stomach distress which I almost take as a sign that this is the "safe" version of iron.

#32 Dorian Grey

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Posted 15 October 2018 - 02:41 AM

I'm not well read on the different forms of iron other than unbound ferric (iron powder used in food fortification), & unbound ferrous (used in a lot of supplements); both of which are (ferrous) or can be (ferric when reduced by vitamin-c or stomach acid or acidic foods) highly reactive and inflammatory. 

 

The fact that you're having an easier time with the IPS would seem to indicate it might be far less inflammatory (and dangerous) than the other forms.  



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#33 John250

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Posted 15 October 2018 - 04:22 PM

I’m starting Jarrows Lactoferrin seems to have great benefits. Then there is apolactoferrin but I can’t seem to find the main difference between the two.

#34 dosquito

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Posted 15 October 2018 - 05:00 PM

I'm guessing jarrow's is apolactoferrin too.



#35 John250

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Posted 15 October 2018 - 05:41 PM

I'm guessing jarrow's is apolactoferrin too.


Jarrows is lactoferrin. life extension has apolactoferrin.

#36 dosquito

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Posted 15 October 2018 - 05:43 PM

I wish they would mention the % of iron. Even LE apolactoferrin is 5% I believe



#37 experimenting

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Posted 21 October 2018 - 01:22 AM

I'm really getting good effects from an RDA equivalent of Ironaid (15mg). My thought is that since it's the RDA the risks are low, but is this a dangerous course of action long term?

#38 Dorian Grey

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Posted 21 October 2018 - 02:28 AM

I'm really getting good effects from an RDA equivalent of Ironaid (15mg). My thought is that since it's the RDA the risks are low, but is this a dangerous course of action long term?

 

Ferritin is a dirt cheap iron lab: https://www.lifeexte...itin-Blood-Test

 

That will fairly accurately let you know where you stand regarding iron stores and accumulation.  

 

The sweet spot for ferritin is between 40 & 60, but anything under 100 should be fairly safe.  Avoid triple digit ferritin like the plague if you wish to enjoy good health throughout your adult life, and live as long as possible.  

 

https://www.longecit...isease-omnibus/

 

https://www.longecit...d-with-disease/

 

https://www.longecit...k-in-longevity/

 

Best Wishes for continued good health.  



#39 dosquito

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Posted 22 October 2018 - 01:58 AM

After a month of apolactoferrin I developed some angular chellitis (could be a coincidence / weather related). went back on normal lactoferrin for a couple days and it’s all but gone now

#40 experimenting

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Posted 26 October 2018 - 10:18 PM

Couple of weeks on this now-its doing something. Equivalent of 15mg per day via LEF ironaid. Don't know whether genetics plays a role but there's something going on here. It feels quite dopaminergic in that my motivation is vastly increased and my body fat is dipping slightly.

Maybe I was deficient, who knows; with regards to iron worries I would note that this is protein bound ie in theory comparable to heme iron, which if I'm not mistaken is "safe"? It's worth noting I'm only at 83% of the RDA right now so shouldn't be any worries. I'm actually considering upping the dosage slightly...

#41 Dorian Grey

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Posted 27 October 2018 - 06:38 AM

Ferritin is indeed remarkably efficient at keeping iron safely bound within its shell.  When it comes to long term storage of large amounts of ferritin in tissues (liver, spleen, kidneys & HEART), ferritin can degrade over time into hemosiderin, which is a bit leakier.  Once this occurs you've got a fine mess on your hands, as hemosiderin is very hard to shift from tissues once it gets laid down.  

 

Like improperly buried toxic waste, hemosiderin leaches free labile iron into tissues, typically at an age when they are least able to deal with chronic inflammation (senior years).  Inflammaging!  

 

Ferrotoxic Disease: http://clinchem.aacc...tent/60/11/1362

 

The Next Great Public Health Challenge.  


Edited by Dorian Grey, 27 October 2018 - 06:44 AM.


#42 kurdishfella

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Posted 02 December 2022 - 08:37 AM

I take iron and it is day one and I feel like I move faster.. I think it has to do with oxygen being distribute better. I also felt initially chills around my body and nausea/headache/tired slighly 


Edited by kurdishfella, 02 December 2022 - 09:03 AM.


#43 kurdishfella

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Posted 02 December 2022 - 11:39 AM

does iron help distribute drugs troughout the body

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#44 ta5

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Posted 27 July 2023 - 12:39 AM

Retraction of Publication  
J Matern Fetal Neonatal Med.

2023 Dec;36(2):2235773.

 
We, the Editors and Publisher of The Journal of Maternal-Fetal and Neonatal Medicine, have retracted the following article:
Mohamed Rezk, Ragab Dawood, Mohamed Abo-Elnasr, Alaa Al Halaby & Hala Marawan (2016)
The Journal of Maternal-Fetal & Neonatal Medicine, 29:9, 1387–1390,
Since publication, significant concerns have been raised about the integrity of the data and reported results in the article. When approached for an explanation, the authors have not responded to the concerns raised, and they have not provided their original data or sufficient supporting information to verify that the research and publication comply with the journal’s Editorial Policies. We have also contacted the author’s institution for further information, but we have not received a reply. As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article, and have informed the authors. The authors do not agree with the retraction.
We have been informed in our decision-making by our policy on publishing ethics and integrity and COPE guidelines.
The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
PMID: 26037728 Retracted. Clinical Trial.
 
 
I took Jarrow Lactoferrin for years, and continue to take it. It never helped increase my ferritin. I believe it only lowered my ferritin. I switched to taking the lactoferrin away from my meals and that has made a big improvement. My ferritin is back to normal. 

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