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Agomelatine potentiates Amphetamine.

agomelatine amphetamine

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#1 John250

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Posted 16 October 2018 - 07:32 PM


This is interesting:

https://www.ncbi.nlm...les/PMC3213641/

Highlights
A 5-HT2C antagonist alone did not produce positive conditioned place preference (CPP).
A selective 5-HT2C antagonist potentiated a low dose amphetamine–induced CPP.
5-HT2C antagonists may lack abuse potential, but may potentiate effects of psychostimulants.

#2 Galaxyshock

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Posted 17 October 2018 - 05:11 AM

If I remember correctly 5-HT2C antagonism increases DA/NA release in the prefrontal cortex and that's where you want activation for executive function.



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#3 John250

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Posted 17 October 2018 - 04:20 PM

If I remember correctly 5-HT2C antagonism increases DA/NA release in the prefrontal cortex and that's where you want activation for executive function.


Yep! I’ve got some pharmacy grade Agomelatine from Buypharma1 I think I’m going to try it.

#4 DeltaWave

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Posted 27 October 2018 - 07:47 AM

Agomelatine's 5-HT2C  antagonism is weak.

(Ki = 631 nM)

You have to use huge doses, or boost it with fluvoxamine.

 

Fluvoxamine, a potent CYP1A2 and moderate CYP2C9 inhibitor markedly inhibits the metabolism of agomelatine resulting in a 60-fold (range 12-412) increase of agomelatine exposure.

 

 

https://ec.europa.eu...nx_54150_en.pdf

 

You will want to protect your liver in either case (Silymarin is a must).


Edited by DeltaWave, 27 October 2018 - 07:49 AM.


#5 John250

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Posted 27 October 2018 - 04:22 PM

The liver studies we’re not done very well. Almost any vitamin, Supplement, drug etc. will have some study showing liver toxicity. If you look at the study only around 1% of users had issues at 25mg/day and 4.6% had issues at 50mg/day...BUT.....2.6% of placebo trials showed liver issues.

https://www.ncbi.nlm...les/PMC4407422/
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#6 vin193

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Posted 06 November 2018 - 04:42 PM

Anyone have info on a sourcing agomelatine? Ceretropic went out of business, all I can find is valdoxan brand pills on sites like rupharma. Bit expensive, but doable if there's nothing else.



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#7 John250

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Posted 07 November 2018 - 07:58 AM

Anyone have info on a sourcing agomelatine? Ceretropic went out of business, all I can find is valdoxan brand pills on sites like rupharma. Bit expensive, but doable if there's nothing else.


Always had success probably order 10 times over the past four years or so.

http://www.buypharma...ine-p-5071.html

Edited by John250, 07 November 2018 - 07:59 AM.






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