12 replies to this topic

[bridge]

Hey all;

My modafinil tolerance is pretty damn high, and I'm spending a lot of damn money on it.

I can't take time off of modafinil ATM, I'm formally diagnosed with several sleep disorders, and I legitimately need modafinil to get out of bed and stay awake during the day.
 

Assuming (and it's just an assumption) Modafinil's primary mechanism of tolerance is induction of enzymes CYP3A4 and CYP450; Would milk thistle aid? I assume getting the enzymes back to "normal" levels would aid a fair amount.

 

Also, I'd guess that a H1 blocker could definitely be of significant help. A few anecdotal reports I've seen corroborate that, but before I go all benadryl gung-ho, I'd like to make sure there's good reason.

 

Last thought on a similar note, wouldn't grapefruit juice potentiate modafinil? If I recall grapefruit juice is primarily CYP3A4, and I believe I read that the majority of modafinil's tolerance mechanism is in CYP450.

 

Any help or thoughts are much appreciated, thanks everyone.

 

[John250]

Hey all;

My modafinil tolerance is pretty damn high, and I'm spending a lot of damn money on it.

I can't take time off of modafinil ATM, I'm formally diagnosed with several sleep disorders, and I legitimately need modafinil to get out of bed and stay awake during the day.

Assuming (and it's just an assumption) Modafinil's primary mechanism of tolerance is induction of enzymes CYP3A4 and CYP450; Would milk thistle aid? I assume getting the enzymes back to "normal" levels would aid a fair amount.

Also, I'd guess that a H1 blocker could definitely be of significant help. A few anecdotal reports I've seen corroborate that, but before I go all benadryl gung-ho, I'd like to make sure there's good reason.

Last thought on a similar note, wouldn't grapefruit juice potentiate modafinil? If I recall grapefruit juice is primarily CYP3A4, and I believe I read that the majority of modafinil's tolerance mechanism is in CYP450.

Any help or thoughts are much appreciated, thanks everyone.

I didn’t think there was any tolerance for Modafinil. What dosage do you use? I thought Modafinil didn’t work any more effective at doses over 300mg.

[bridge]

I didn’t think there was any tolerance for Modafinil. What dosage do you use? I thought Modafinil didn’t work any more effective at doses over 300mg.

 

For the majority of users I doubt there is, but running it daily for years definitely leads to tolerance, at least in my experience.

 

I can't afford Provigil or generic's copay, so I order from India;

Generally my doses are around 400mg of Sun Pharma's Modalert, however I've been pressed for cash the last few months so my most recent order, and the one that's in customs right now are Hab pharma. I'm not sure if it's me or their modafinil, but going off of their claimed mg/pill; I'm running around 800mg a day just to stay awake.

The tolerance is a serious issue because I just got a job after a brief unemployment following a layoff, and I need to wake up and get to this job to keep my apartment; Unfortunately, I'm almost out of mod because I'm eating 800mg to even see effects.

I'll order SunPharma next time, I'm sure that's part of the issue; but I still need to stretch out these 1800mg of Hab Mod, plus the 1000mg Generic provigil my PCP wrote me, for as long as humanly possible.

[John250]

For the majority of users I doubt there is, but running it daily for years definitely leads to tolerance, at least in my experience.

I can't afford Provigil or generic's copay, so I order from India;

Generally my doses are around 400mg of Sun Pharma's Modalert, however I've been pressed for cash the last few months so my most recent order, and the one that's in customs right now are Hab pharma. I'm not sure if it's me or their modafinil, but going off of their claimed mg/pill; I'm running around 800mg a day just to stay awake.

The tolerance is a serious issue because I just got a job after a brief unemployment following a layoff, and I need to wake up and get to this job to keep my apartment; Unfortunately, I'm almost out of mod because I'm eating 800mg to even see effects.

I'll order SunPharma next time, I'm sure that's part of the issue; but I still need to stretch out these 1800mg of Hab Mod, plus the 1000mg Generic provigil my PCP wrote me, for as long as humanly possible.

Maybe try Armodafinil?

[BrankLucas]

Have you considered switching to amphetamine? Or is there a reason you can't use a stronger stimulant? Also, not sure if they have this where you are, but anecdotally I noticed that when my venlafaxine dose was increased to the point where it turned from an SSRI, into an SNRI(norepinepherine reuptake as well), it made staying awake easier. Maybe there are some sort of norepinepherine based stimulants like strattera or something for you. Not really sure if that's helpful since IDK if a doctor would prescribe you both, but it's something I've found that kept me awake.

Edited by BrankLucas, 29 November 2018 - 06:26 PM.

[bridge]

Have you considered switching to amphetamine? Or is there a reason you can't use a stronger stimulant?

There is, I’m recovering from a pretty ugly cocaine addiction, and adderal lead me to cocaine. I’d rather stay away from anything dopaminergic. Fl-mod works wonders but I can’t find it atm, I’ve used 4F-MPH with god effects but I’m not comfortable running it daily.

[John250]

There is, I’m recovering from a pretty ugly cocaine addiction, and adderal lead me to cocaine. I’d rather stay away from anything dopaminergic. Fl-mod works wonders but I can’t find it atm, I’ve used 4F-MPH with god effects but I’m not comfortable running it daily.

https://www.amazon.c...pop_mb_pd_title

This place is out of stock but email them as they don’t update their website often.

https://maresearchch...ated-modafinil/

Edited by John250, 29 November 2018 - 11:08 PM.

[BrankLucas]

You are correct about grapefruit juice potentiating modafinil. I feel like most other solutions are just going to be a matter of putting duct tape on the problem, I didn't think of it before, but you should get memantine and use it with modafinil. It's used to prevent tolerance buildup of dopaminergic drugs such as modafinil, I didn't know it but even doctors use it for this purpose as my psychiatrist told me. But he offered me a 20 my prescription which starting with that much you might find unpleasant, as me and many others have when not titrating up the dose. You can get it from nootropics sites too without a prescription. The drug in itself tends to keep people awake.

[bridge]

https://www.amazon.c...pop_mb_pd_title

This place is out of stock but email them as they don’t update their website often.

https://maresearchch...ated-modafinil/

Quite familiar with CRL, I suspect it's a significant part of my modafinil tolerance to be honest - I'd be all over it, but A. I don't trust many vendors, and B. Using it for more than 2-3 days in a row makes my lips so dry the skin flakes off, and small wounds open up in the corners of my lips.

 

You are correct about grapefruit juice potentiating modafinil. I feel like most other solutions are just going to be a matter of putting duct tape on the problem, I didn't think of it before, but you should get memantine and use it with modafinil. It's used to prevent tolerance buildup of dopaminergic drugs such as modafinil, I didn't know it but even doctors use it for this purpose as my psychiatrist told me. But he offered me a 20 my prescription which starting with that much you might find unpleasant, as me and many others have when not titrating up the dose. You can get it from nootropics sites too without a prescription. The drug in itself tends to keep people awake.

I was lucky enough to snag a bottle of memantine from irc before they closed, I've been somewhat torn around taking it. I've heard a lot of horror stories, 99% of which I'm sure could be avoided with titration, but I'm still on the fence. Is there a dosing protocol you'd recommend? Thanks in advance.

[BrankLucas]

Not really, It's been too long, just go look it up on here or Reddit. IIRC it's an increase of 5mg per week. IDK what you mean by horror stories unless you're talking about people taking too much. I have bought it from nootropics source or Depot previously, I don't remember which but they also have some you can buy afterwards

[John250]

You are correct about grapefruit juice potentiating modafinil. I feel like most other solutions are just going to be a matter of putting duct tape on the problem, I didn't think of it before, but you should get memantine and use it with modafinil. It's used to prevent tolerance buildup of dopaminergic drugs such as modafinil, I didn't know it but even doctors use it for this purpose as my psychiatrist told me. But he offered me a 20 my prescription which starting with that much you might find unpleasant, as me and many others have when not titrating up the dose. You can get it from nootropics sites too without a prescription. The drug in itself tends to keep people awake.

I didn’t react well to Memantine. I even started at 2.5mg and titratied up to 5-10mg but after a few weeks I noticed I got more impulsive and actually needed more amphetamines than I normally would have.

[cat-nips]

Wakalert - armodafinil.  Works just as fast but lasts longer, so you don't need to dose so often.  Keep your doses stable with the minimum amount you need to wake up in the morning, and force your body to adjust with other natural boosts if necessary.  Don't chase the çomeup and in the late morning, early afternoon, supplement with a smaller dose of the Provigil if you have to or stack it with something like Tyrosine, CILTEP, ALCAR, Uridine, Racetams or something.  

 

A cup of strong black tea will probably potentiate Modafinil, without raising blood pressure.  Benedryl, idk.  Modafinil works by mechanisms of raising histamine levels greatly, Benedryl reduces histamine and there may be a cancellation of effects, but not sure.  Benedryl, and all things thing lower histamine are usually anticholinergic, sedating, and probably not so healthy in large, consistent dosages and possibly something to avoid if you can.  

 

I take Armodafinil every day, and have been playing with Moda products for the last year to get over amphetamine treatment.  I never go beyond 75mg Wakalert once a day, in the morning, with coffee, and am currently working on a new stack in combination with Armodafinil + other things to make it more effective.  Will report back if I find something synergistic and sustainable for daily use.  

Edited by cat-nips, 02 December 2018 - 04:35 PM.

[cat-nips]

800mg of Moda a day is pretty high.  Tolerance or not, that can't be so good on your liver or your other organs.  Don't mean to sound preachy, but maybe consider lowering your dose and adding some precursors to supplement with in addition to the lowerd dose.  Yes, milk thistle is supposedly helpful in liver function.  Some people report that grapefuit juice can enhance the effects of stims, but it's listed as reducing the levels of meds in the body.  Not sure what it would do to Moda.  Maybe something like CILTEP + Moda in smaller divided doses would be helpful.  Or grapefruit juice later on in the evening for its alkalizing effects and to not interfere with moda absorption earlier.  

Edited by cat-nips, 02 December 2018 - 06:31 PM.