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[Harkijn]

This recent review of NAD+ generation gives us a renewed overview of this complicated subject. Because it is relatively understandable for us non-biochemists I place a link here.

The authors do not value the supplementation of NAM, but allocate a possible upside  to the production of NAM after NR/NMN supplementation.

No mention of  poor bio-availibility of NR/NMN.

https://www.ncbi.nlm...les/PMC6145238/

[albedo]

Thank you Harkijn. Interesting while I think known to many of you: "...There are several ongoing clinical studies that are currently further assessing the safety, efficacy and impact of either NR or NMN supplementation on a wide range of health parameters including vascular endothelial function, immune function, kidney function, muscle mitochondrial function, cognitive function and energy metabolism (see clinicaltrials.gov). Although there is still much to learn regarding the clinical impact of NR and NMN supplementation, currently no adverse effects have been reported (Trammell et al. 2016a , Airhart et al. 2017)...."