8 replies to this topic

[Kevnzworld]

“ These findings might have important implications in understanding how metformin could confer health benefits via maintenance of SIRT1 when NAD+ levels decline during the aging process.”
https://www.frontier...i7HcdK12NhXgf1Y

[theone]

The capacity of metformin to operate as a direct pharmacological SIRT1 activator, which was defined by the selective targeting of SIRT1 and not the AMPK/mTOR pathway in vitro and in vivo by therapeutic doses in mice and humans (27, 38), has been further bolstered by the finding that the combination metformin and leucine allows SIRT1 to operate at lower NAD+ concentrations in cell-free system

 

 

This is interesting!

[tunt01]

Very interesting

[male_1978]

So what does this mean for us?
 

- We know more about safety and life extension in humans by metformin than with any other drug (on the marked since 1960).

- We know metformin does not raise cancer risk and prolongs life. 

- Dr. Sinclair takes it...

- The new information is that one of its effect is via activating SIRT1.

 

 

This could be seen as indication that activating SIRT1 is mostly safe, right? It does not say anything about other side effects of increased NAD+ of course, and it doesnt mean that the life prolonging effect of metformin is because of this pathway.

 

What are your conclusions from this finding?

 

[Kevnzworld]

From the study
“ This is further support for the importance of NAD+ in maintaining metabolism and the role of SIRT1 in that process. It is interesting that metformin may be compensating for the loss of NAD+ in age via the direct activation of SIRT1.”

I take both NR and Metformin..

[Fredrik]

I take both NR and Metformin..

 

If you want to share. How much of each do you take and do you take them qd, bid or tid? Thank you.

[MikeDC]

This is in vitro study. Metformin might have a small impact on longevity. If the impact is large, we would have known about it already since the history of its use is very long.

[Kevnzworld]

This is in vitro study. Metformin might have a small impact on longevity. If the impact is large, we would have known about it already since the history of its use is very long.

The reason I posted this in the NAD forum is because Sirt1 is dependent on NAD. There seems to be an obvious synergy and the reason that Basis combines peterostilbene with NR.
It seems intuitive that the Sirt1 enhancing ability of Metformin is why Sinclair takes it.
Metformin should be more effective long term when combined with NR or NMN.

[MikeDC]

Actually you have to use NR when using metformin because metformin reduces NAD+/NADH ratio.