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potential of NR in vivo supplementation to improve recovery of patients suffering from hematological failure including p

nad+

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#1 stefan_001

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Posted 30 November 2018 - 09:24 PM


http://www.bloodjour...so-checked=true

 

In vivo, NR dietary supplementation resulted in a significantly enlarged pool of progenitors, without concurrent HSC exhaustion, improved survival by 80%, and accelerated blood recovery after murine lethal irradiation and limiting-HSC transplantation. In human xenotransplanted immune-deficient NSG mice, NR increased the production of human leucocyte progeny from hCD34+ progenitors.

 

 

And then this one for those that believe there are other paths:

 

Here we show that the NAD+-boosting agents Nicotinamide Riboside (NR) and Nicotinamide MonoNucleotide (NMN) reduce mitochondrial activity within HSCs through increased mitochondrial clearance via autophagy and possibly the Unfolded Protein Response mitochondria (UPRmt), leading to increased asymmetric HSC divisions as measured by asymmetric mitochondrial distribution in single cell pair-daughter analysis. This process was abrogated in Nrk1-/-;Nrk2-/- double knock out mice, which cannot incorporate NR into the NAD+ salvage pathway.

 

 


Edited by stefan_001, 30 November 2018 - 09:25 PM.

  • Informative x 1

#2 MikeDC

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Posted 01 December 2018 - 01:08 AM

Lots of garbage studies in biology. The results depend who did it.
  • Agree x 1





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