• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Does your dose of NMN depend on how much exercise you do that day?

nmn

  • This topic is locked This topic is locked
4 replies to this topic

#1 RichardAlan

  • Guest
  • 75 posts
  • 1
  • Location:Australia
  • NO

Posted 08 December 2018 - 11:24 AM


I usually walk around 7-10 miles a day and am wondering about what dose of NMN to take.  I read some people change the dose depending on how much they exercise.  With my 7-10 miles / day should I be changing my dose or leave constant at the same amount of say 500mg / day?



#2 able

  • Guest
  • 851 posts
  • 406
  • Location:austin texas
  • NO

Posted 08 December 2018 - 02:32 PM

I believe most of us who vary our dosage are trying to avoid homeostasis - the body adjusting to the external supplementation and lowering its own production, or excreting more of the external dose.

 

Some of the studies with NR show 1,000 mg a day resulting in an initial increase in NAD, that then drops down quite a bit in month 2 and beyond.

 

With that in mind, cycling your dosage may be helpful to avoid the homeostasis.  Or not - no-one really knows.

 

It does seem to help exercise capacity, and makes sense to me that if cycling, it would be best to do more on days you exercise.

 

Personally, I take a lot on the 3  days a week I exercise intensely (HIIT).  Other days, I might take a scoop in the morning to help me wake up, but nothing more, and none on weekends.

 


  • Good Point x 2
  • Agree x 1

#3 Oakman

  • Location:CO

Posted 10 December 2018 - 03:14 PM

^ I second able's opinion, and agree specifically with "No one really knows". Also, there's the financial aspect, supplements like NMN, NR, NAD+ aren't inexpensive, i.e., high dosing costs a lot on a continuous basis, esp. if you use several.


  • Good Point x 2

#4 bluemoon

  • Guest
  • 761 posts
  • 94
  • Location:south side
  • NO

Posted 13 December 2018 - 06:52 PM

 

 

Some of the studies with NR show 1,000 mg a day resulting in an initial increase in NAD, that then drops down quite a bit in month 2 and beyond.

 

 

The Chromadex study on the TruNiagen website shows a sustained level of NAD+ increase over several weeks. The U of Colorado study doesn't show a drop after six weeks at 1000 mg either. Elysium Basis' 500 mg dose does show a drop after four weeks. Can you link to the 1,000 mg studies that show a decline? 


  • Agree x 1

#5 able

  • Guest
  • 851 posts
  • 406
  • Location:austin texas
  • NO

Posted 15 December 2018 - 04:04 PM

The Chromadex study on the TruNiagen website shows a sustained level of NAD+ increase over several weeks. The U of Colorado study doesn't show a drop after six weeks at 1000 mg either. Elysium Basis' 500 mg dose does show a drop after four weeks. Can you link to the 1,000 mg studies that show a decline? 

 

Ah, my mistake.  I was mostly thinking of the Elysium study that showed drop from 60% to 40-50% after 4 weeks, but was at 500 Mg per day.

 

The other 1,000 mg I was thinking of was Dr Brenner himself in the Trammel thesis, showed a drop at the end of his 7 day usage, but that was N=1 and really meaningless.

 

The U of Colorado only published the single data point at 6 weeks, showing 60% increase, so we don't know if that is stable or not.

 

I am interested to see the Chromadex study when they publish.  It is encouraging that they show sustained NAD+ increase over 8 weeks at 1,000 mg.  Perhaps that is more effective than 500 mg.







Also tagged with one or more of these keywords: nmn

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users