It might be like alcohol or recreational drugs, and have a great effect on mood, but not be good for your health.
The research does show that NADH also falls as we age, but not as much as NAD+.
I don't think there is any disagreement among researchers that the benefit from NAD+ precursors is from increasing the NAD+/NADH ratio.
Taking NADH is going in the wrong direction and I can't imagine how it is actually good for your health.
Let me first say I wasnt the one that downvotes you as Im actually glad that the NADH is finally discussed (believe I made a post a few days ago on the subforum regarding NADH and longevity which was unanswered, which really puzzled me since thats what this forum is all about oO).
Anyway I found these papers:
Please note this is in people with CFS and uses a combo of 20mg nadh and 200mg coq10,
https://www.ncbi.nlm...les/PMC4346380/
'A significant improvement of fatigue showing a reduction in fatigue impact scale total score (p<0.05) was reported in treated group versus placebo. In addition, a recovery of the biochemical parameters was also reported. NAD+/NADH (p<0.001), CoQ10 (p<0.05), ATP (p<0.05), and citrate synthase (p<0.05) were significantly higher, and lipoperoxides (p<0.05) were significantly lower in blood mononuclear cells of the treated group. These observations lead to the hypothesis that the oral CoQ10 plus NADH supplementation could confer potential therapeutic benefits on fatigue and biochemical parameters in CFS.'
It lowered their nad/nadh ratio by as much as 75% looking at the graph, halvened their lipid peroxidation, doubled their nadh, increased their coq10 by like a factor 2.5.
What the consequences of this are for their longterm health Id also really want to know, but it seemed to really help these people with their fatigue
Calorie restriction extends yeast life span by lowering the level of NADH.
https://www.ncbi.nlm...cles/PMC314267/
"Here we test whether CR activates Sir2 by increasing the NAD/NADH ratio or by regulating the level of nicotinamide, a known inhibitor of Sir2. We show that CR decreases NADH levels, and that NADH is a competitive inhibitor of Sir2. A genetic intervention that specifically decreases NADH levels increases life span, validating the model that NADH regulates yeast longevity in response to CR."
As a niagen user myself (in the past) I could feel a partial overlap between NADH and niagen (muscle soreness wise and endurance), could it be possible that NADH supplementation force the usage of NAD present in the body somehow? And by doing this NADH supplementation would eventually make one burn through all their endogenous NAD, leaving one exhausted and crashed?
Has anyone found any studies regarding NADH supplementation and longterm healthy effects/longevity?
Edited by MankindRising, 21 December 2018 - 10:53 AM.