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Re-started NADH supplementation (properly this time)

nadh

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#1 MankindRising

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Posted 18 December 2018 - 11:45 AM


Just wow to this stuff,sublingual 20mg from blisterpacks -enada.

Pronounced mood brightening,slight tendency towards hypomania. Not sure if sustainable but Im combining it with 2x 1000mg glucuronolactone.

 

I should add that it completely eliminates any form of little aches and pains (similar to niagen) and I take it together with my regular stack of biogaia gastrus, panax ginseng, coq10, guarana,vitamin c and mag citrate.

 

How come theres so little talk about this supplements, its very fast acting and very pronounced.


Edited by MankindRising, 18 December 2018 - 11:46 AM.


#2 MankindRising

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Posted 19 December 2018 - 01:36 PM

This stuff is just crazy, if you suspect you suffer from low bh4 and elevated brain and muscle lactate (due to poor metabolism/mito health) and are a responder to vitamin c you have to try this, the sublingual stuff is incredibly fast acting. After the lozenge has full dissolved under tongue it can be felt as soon as within 2-10mins. The effect seems never-ending, even at the end of the day the effect is still pronounced if you take it first thing morning. This stuff blows me away regarding mental endurance and clearheadedness.

Beats ritalin hands down for me. Can imagine that stacking this with precursors such as tryptophan and tyrosine can send ppl into mania.

 

Make sure you got some CoQ10 on standby and some gaba-ergic herbs to somewhat smoothen out the stimmy feel it can give at times. If your bipolar you definetely want to stay away from this stuff imo.


Edited by MankindRising, 19 December 2018 - 01:40 PM.


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#3 ironfistx

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Posted 20 December 2018 - 12:56 AM

What did you do that wasn't correct last time?



#4 MankindRising

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Posted 20 December 2018 - 10:27 AM

What did you do that wasn't correct last time?

Never pinned the effects that I was getting back then to NAD as I was using multiple stuff at the same time. I know for certain its the NADH now though thats giving me the effects that I described above.



#5 MikeDC

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Posted 20 December 2018 - 08:49 PM

You maybe very low on NAD+. NADH is actually the bad form of NAD. Higher ratio of NAD+/NADH is good for health.
Best way to increase NAD+ is to take Tru Niagen.

#6 MankindRising

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Posted 21 December 2018 - 01:11 AM

Ive used niagen before its indeed powerfull stuff, however NADH has way more energizing effects. Niagen felt more like recovery from exercise in a pill.

Would administrating long term NADH be bad for health? From what I have read NADH also decreases with age, not just NAD.

 

Also since NADH is quite potent at elevating BH4 (through recycling BH2 back to BH4)it would help prevent excessive NO from oxidizing?


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#7 able

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Posted 21 December 2018 - 01:56 AM

It might be like alcohol or recreational drugs,  and have a great effect on mood, but not be good for your health.

 

The research does show that NADH also falls as we age, but not as much as NAD+. 

 

I don't think there is any disagreement among researchers that the benefit from NAD+ precursors is from increasing the NAD+/NADH ratio.

 

Taking NADH is going in the wrong direction and I can't imagine how it is actually good for your health.

 

 


Edited by able, 21 December 2018 - 01:57 AM.

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#8 MikeDC

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Posted 21 December 2018 - 03:24 AM

Yes. Temporary surge in energy and long term health are different things.
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#9 MankindRising

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Posted 21 December 2018 - 10:45 AM

It might be like alcohol or recreational drugs,  and have a great effect on mood, but not be good for your health.

 

The research does show that NADH also falls as we age, but not as much as NAD+. 

 

I don't think there is any disagreement among researchers that the benefit from NAD+ precursors is from increasing the NAD+/NADH ratio.

 

Taking NADH is going in the wrong direction and I can't imagine how it is actually good for your health.

Let me first say I wasnt the one that downvotes you as Im actually glad that the NADH is finally discussed (believe I made a post a few days ago on the subforum regarding NADH and longevity which was unanswered, which really puzzled me since thats what this forum is all about oO).

 

Anyway I found these papers:

 

Please note this is in people with CFS and uses a combo of 20mg nadh and 200mg coq10,

https://www.ncbi.nlm...les/PMC4346380/

 

'A significant improvement of fatigue showing a reduction in fatigue impact scale total score (p<0.05) was reported in treated group versus placebo. In addition, a recovery of the biochemical parameters was also reported. NAD+/NADH (p<0.001), CoQ10 (p<0.05), ATP (p<0.05), and citrate synthase (p<0.05) were significantly higher, and lipoperoxides (p<0.05) were significantly lower in blood mononuclear cells of the treated group. These observations lead to the hypothesis that the oral CoQ10 plus NADH supplementation could confer potential therapeutic benefits on fatigue and biochemical parameters in CFS.'

 

It lowered their nad/nadh ratio by as much as 75% looking at the graph, halvened their lipid peroxidation, doubled their nadh, increased their coq10 by like a factor 2.5.

What the consequences of this are for their longterm health Id also really want to know, but it seemed to really help these people with their fatigue

 

 

Calorie restriction extends yeast life span by lowering the level of NADH.

https://www.ncbi.nlm...cles/PMC314267/

 

"Here we test whether CR activates Sir2 by increasing the NAD/NADH ratio or by regulating the level of nicotinamide, a known inhibitor of Sir2. We show that CR decreases NADH levels, and that NADH is a competitive inhibitor of Sir2. A genetic intervention that specifically decreases NADH levels increases life span, validating the model that NADH regulates yeast longevity in response to CR."

 

 

As a niagen user myself (in the past) I could feel a partial overlap between NADH and niagen (muscle soreness wise and endurance), could it be possible that NADH supplementation force the usage of NAD present in the body somehow? And by doing this NADH supplementation would eventually make one burn through all their endogenous NAD, leaving one exhausted and crashed?

Has anyone found any studies regarding NADH supplementation and longterm healthy effects/longevity?


Edited by MankindRising, 21 December 2018 - 10:53 AM.


#10 airplanepeanuts

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Posted 24 December 2018 - 12:56 AM

Ive used niagen before its indeed powerfull stuff, however NADH has way more energizing effects. Niagen felt more like recovery from exercise in a pill.

Would administrating long term NADH be bad for health? From what I have read NADH also decreases with age, not just NAD.

 

Also since NADH is quite potent at elevating BH4 (through recycling BH2 back to BH4)it would help prevent excessive NO from oxidizing?

 

I asked the same question a few years back: https://www.longecit...es-again/page-2

 

According to the answer by Hebbeh NADH shouldn't be a problem.



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#11 Bubbles

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Posted 09 January 2019 - 09:56 PM

Got NADH first time few weeks ago, wasn't even morning or empty stomach, about 2PM, put it under my tongue; 12mg of it. 

 

Just wow! I remember telling myself that no way this is placebo, the way I felt it's like I re-winded time with 10 years. Is the best supplement I ever tried that simply made my unexplained day sleepiness go away; my "chronic fatigue/adrenal fatigue" sort of problem. I felt as myself, difficult to explain.

 

Took it the second day, similar effects again, and kept taking it for about a week until I realized that it won't necessarily make me feel like the first time because 1 dose like this can have some lingering effects for quite some time and also the initial energy bump is not happening but also in the same time I am not feeling lethargic or back to the "problem". Which made me realize I should use this strategically, 1-2 times per week, maybe even just 1 time per week, it seems to have a lasting effect, take this with a grain of salt of course. Interesting enough, just today I also found someone's post who made the same statement/reached the same conclusion: https://www.longecit...ic/#entry518738 "It heightens my mood and I can think quicker when I take it. The main effect I get from it is the speed of thought. The effect is subtle but obvious when I realise that I can pay attention to multiple things easier for example. It is important not to take it more than a few days in a row because the effect diminishes. It is ideal to use as needed, when you are sleep deprived nomore than a few times per week."

 

The only problem is that despite reading a lot, I still do not really understand what I am doing nor do I understand the difference of NAD+ vs NADH even if I read about the difference. NAD+ nicotinamide riboside while NADH is called coenzyme 1? Now I even get confusing about nictinamide riboside vs. d-Ribose supplement? Different things right?

 

My first thought when I initially bought it was to stack NADH with Q10 and ALCAR. Since first to take that day was NADH, i noticed NADH is a 1-pill stack itself lol. Little joke; actually I did NADH + Q10 + ALCAR, interesting enough, I think the Q10 did nothing, ALCAR may depend (seems to help with mental mood for me, anecdotal of course) and NADH was the main thing. I am wondering now what if I replace Q10 with d-Riboside? Or what if someone takes NAD+ with NADH together?







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