8 replies to this topic

[RichardAlan]

Would like to get some suggestions from the members of this forum on supplements and dosage that they recommend for short and longer term brain health.  I'm 62 years old, on a vegan diet with good healthy

[Dorian Grey]

The myelin sheath's of neurons are around 80% lipid in composition, & transition metals like iron and copper act as a catalyst for lipid oxidation.  Iron & copper are also commonly found to be elevated in brains of those who have Alzheimer's. 

 

https://www.ncbi.nlm...les/PMC2812924/

 

Vegan's probably don't have a lot of trouble with excess iron, but I've read copper can be elevated in vegans. Some feel copper is more strongly associated with Alzheimer's than iron.  Look Here:

 

http://www.townsendl...copper1013.html

 

Chelating copper can be difficult, but dietary zinc is supposed to greatly reduce absorption of dietary copper, & vegan sources of zinc are limited.  Something you might wish to explore further.  

 

Vitamin-E is the bodies primary lipid anti-oxidant, & E has been shown to slow progression of Alzheimer's.  Might it also help prevent it?  Seems logical, & I'm a believer.  Vitamin-E also the most common deficiency in the standard diet (see attached pdf).  Vegan's may do better than most regarding Vitamin-E intake, but higher levels of polyunsaturated vegetable oils increases demand on Vitamin-E, so you may need more E if your dietary PUFA intake is elevated.  

 

I'm also very interested in membrane support (mitochondrial and cellular) and phosphatidylcholine (lecithin) has some good science behind it regarding membrane support.  Vegan's may also be a bit short on dietary choline (required to make acetylcholine / neurotransmitter), and Lecithin may be helpful in providing support in this area.  More on this here:

 

https://www.ncbi.nlm...les/PMC2642958/

 

Both Vitamin-E (natural form with mixed tocopherols) & Lecithin are fairly benign and cheep supplements.  Vitamin-E does thin the blood slightly, but I see this as a good thing.  I'm 62 myself, & thrombotic stroke is a major brain-buster in senior populations.  These can occur as a singular massive event, but multiple "mini-stroke" events are also common, and can add up over time.  Because of this, I see the minor blood thinning properties of Vitamin-E as a good risk/reward deal.  Prescription blood thinners are commonly prescribed in senior populations.  I'd prefer to avoid the big-guns prescriptions if possible, but a little thinning from supplements or even daily baby aspirin seems wise.  

 

Hope this helps, & Best of luck staying sharp.  

 

 

Attached Files

•  Vitamin-E Most Common Deficiency.pdf   200.13KB   4 downloads

Edited by Dorian Grey, 19 December 2018 - 05:16 AM.

[MikeDC]

Would like to get some suggestions from the members of this forum on supplements and dosage that they recommend for short and longer term brain health. I'm 62 years old, on a vegan diet with good healthy

The only thing that can truly slow down brain ageing and Alzheimer’s is NAD+ precursor Tru Niagen. Multiple studies show Tru Niagen can ameliorate cognition impairment and prevent Alzheimer’s in mice. 3 human clinical trials are in progress using Tru Niagen for cognitive impairment. My friend’s dad who is 80 said his brain fog disappeared after taking Tru Niagen. Of course brain is not the only organ it helps. It helps to rejuvenate all cells in the body

[Daniel Cooper]

The only thing that can truly slow down brain ageing and Alzheimer’s is NAD+ precursor Tru Niagen. Multiple studies show Tru Niagen can ameliorate cognition impairment and prevent Alzheimer’s in mice. 3 human clinical trials are in progress using Tru Niagen for cognitive impairment. My friend’s dad who is 80 said his brain fog disappeared after taking Tru Niagen. Of course brain is not the only organ it helps. It helps to rejuvenate all cells in the body

 

 

I'd certainly like to see some human trial evidence of that statement rather than an anecdote about your friend's dad.

[MikeDC]

I'd certainly like to see some human trial evidence of that statement rather than an anecdote about your friend's dad.

The results of the first clinical trials on Cognition will be published end of 2019 or early 2020. You can wait until then.

[Daniel Cooper]

The results of the first clinical trials on Cognition will be published end of 2019 or early 2020. You can wait until then.

 

 

I thought we were scheduled to see these results before then. Have they slipped?

[MikeDC]

I thought we were scheduled to see these results before then. Have they slipped?

We will probably see the publication of ChromaDex’s own dose trial soon. But the cognitive trial just finished and will probably take a year to publish.

https://clinicaltria...iboside&rank=23


https://clinicaltria...e&draw=3&rank=9


https://clinicaltria...iboside&rank=24

Edited by MikeDC, 19 December 2018 - 08:44 PM.

[MikeDC]

New hope for Alzheimer’s is Niagen. Harvard Professor Rudy Tanzi also bought ChromaDex stock. Shows his confidence in Niagen treating early Alzheimer’s or prevent Alzheimer’s.

https://www.biospace...es-and-new-hope

[John250]

The myelin sheath's of neurons are around 80% lipid in composition, & transition metals like iron and copper act as a catalyst for lipid oxidation. Iron & copper are also commonly found to be elevated in brains of those who have Alzheimer's.

https://www.ncbi.nlm...les/PMC2812924/

Vegan's probably don't have a lot of trouble with excess iron, but I've read copper can be elevated in vegans. Some feel copper is more strongly associated with Alzheimer's than iron. Look Here:

http://www.townsendl...copper1013.html

Chelating copper can be difficult, but dietary zinc is supposed to greatly reduce absorption of dietary copper, & vegan sources of zinc are limited. Something you might wish to explore further.

Vitamin-E is the bodies primary lipid anti-oxidant, & E has been shown to slow progression of Alzheimer's. Might it also help prevent it? Seems logical, & I'm a believer. Vitamin-E also the most common deficiency in the standard diet (see attached pdf). Vegan's may do better than most regarding Vitamin-E intake, but higher levels of polyunsaturated vegetable oils increases demand on Vitamin-E, so you may need more E if your dietary PUFA intake is elevated.

I'm also very interested in membrane support (mitochondrial and cellular) and phosphatidylcholine (lecithin) has some good science behind it regarding membrane support. Vegan's may also be a bit short on dietary choline (required to make acetylcholine / neurotransmitter), and Lecithin may be helpful in providing support in this area. More on this here:

https://www.ncbi.nlm...les/PMC2642958/

Both Vitamin-E (natural form with mixed tocopherols) & Lecithin are fairly benign and cheep supplements. Vitamin-E does thin the blood slightly, but I see this as a good thing. I'm 62 myself, & thrombotic stroke is a major brain-buster in senior populations. These can occur as a singular massive event, but multiple "mini-stroke" events are also common, and can add up over time. Because of this, I see the minor blood thinning properties of Vitamin-E as a good risk/reward deal. Prescription blood thinners are commonly prescribed in senior populations. I'd prefer to avoid the big-guns prescriptions if possible, but a little thinning from supplements or even daily baby aspirin seems wise.

Hope this helps, & Best of luck staying sharp.

Check out Salvia miltiorrhiza(DanShen)and Angelica keiskei Koidzumi(Ashitaba)for blood thinning.

https://www.ncbi.nlm...les/PMC5421141/

https://www.science....eiskei angelica

https://www.ncbi.nlm...ubmed/29441970/