16 replies to this topic

[dosquito]

This is rarely discussed, but I read in a few places that you should take tmg with nr. thoughts?

[Phoebus]

yeah good question, I have wondered myself 

 

some early adopters of NR insisted that you should take TMG with your NR as NAD+ precursors potentially put a strain on the methylation system

 

but no one seems to talk about it anymore. No idea why

[sinkpoint]

I started to have anxiety after taking NR at about 300mg, and experimenting with ~500mg for about a year. Started taking TMG and it immediately went away. So I'm sticking with it. 

I think there's is some truth to the idea of NR consuming methyl donors. I also know people who don't report this, so there might be individual variability. 

Edited by sinkpoint, 22 December 2018 - 04:19 PM.

[dosquito]

How much tmg do you take?

how old are you and what have you noticed from nr? and how did you choose that over nmn?

Edited by dosquito, 22 December 2018 - 05:08 PM.

[scooterboy]

What dose the letters TMG mean ?

[tunt01]

I think they should be administered in equimolar amounts. [1]  If you look up the Thorne cardiovascular product that has both NMR and betaine, you can approximate the ratio.  I did the math on it (somewhere in these forums) and they are equimolar.

 

 

 

1.  McCarty MF. (2018). Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy. - PubMed - NCBI . Ncbi.nlm.nih.gov. Retrieved 23 December 2018, from https://www.ncbi.nlm...pubmed/10985907

[sinkpoint]

How much tmg do you take?

how old are you and what have you noticed from nr? and how did you choose that over nmn?

 

1000mg 

 

I'm 35. Responded very well with NR, my body now responds likes when I was in my 20s. I also tried NMN sublingual, the result was very similar. So I'm sticking with NR due to cost, and ease of consumption (capsule vs sublingual). 

[Engadin]

What dose the letters TMG mean ?

 

 

https://en.wikipedia...rimethylglycine

[joesixpack]

I am one of the people that cannot tolerate high doses of NR. I am able to to take 125 mg of it now, when I take 500 mg of TMG for the methylation issue.

[chipw]

I take 648mg TMG (Douglas labs Betaine) and 500mg Niagen daily.  i skip a day or two every once in a while.  No problems, only positives so far.  Im 48 and have a MTHFR mutation 

[Ambrosia]

Interesting topic, from my research people who get mental side effects due to NR or can’t tolerate high doses seem to benefit from TMG. Im going to experiment on this soon and see if it helps me tolerate higher doses

[ledgf]

I don't think TMG is dangerous... but it's in so many foods, how could you be deficient in it? 

[Benko]

I just ran across this in one of Chris Masterjohn’s YouTube videos, and his comment was exactly as stated that it puts “stress on methylation” and he recommends avoiding niagen, or if you really must, to take equal amounts TMG.

Does anyone know if the question of niagen effecting methylation has been discussed here?

Thanks.

[Phoebus]

there are other methyl donors available such as methyl folate, methylcobalamin, methionine, and choline. 

 

just an FYI

[joesixpack]

I take it and I think it helps. I am one of the people that can't take a full dose of NR due to the side effects. One of the reasons may be the methylation effect, and this may help.

[chipw]

there are other methyl donors available such as methyl folate, methylcobalamin, methionine, and choline.

just an FYI

Are you saying to take those instead of tmg or in addition to tmg? Thanks

[Phoebus]

Are you saying to take those instead of tmg or in addition to tmg? Thanks

 

I;m saying they are other options, I dont know how much methyl donors any one person might need.