I stopped taking MitoQ after seeing this study:
The targeted anti‐oxidant MitoQ causes mitochondrial swelling and depolarization in kidney tissue
https://www.ncbi.nlm...les/PMC5880956/
What are your thoughts about it?
I sent the report ncbi.nhi to Mitoq to have their rating and this is their response mail: from Customer Service (mitoQ):
"Hi Francesco
Thanks for your concern regarding the recent kidney paper.
We can confidently assure you that this paper is not relevant for those taking MitoQ. This research was done in a test tube and at concentrations much higher than would ever occur in the body. MitoQ has been extensively evaluated for safety and is currently being evaluated in a clinical trial to assist with kidney health at Delaware University
Please find below a list of studies which show that MitoQ is protective in kidneys:
1. Mitochondria-targeted antioxidant MitoQ reduced renal damage caused by ischemia-reperfusion injury in rodent kidneys: Longitudinal observations of T2 -weighted imaging and dynamic contrast-enhanced MRI. Liu X et al. Magn Reson Med. 2018 Mar;79(3):1559-1567. DOI: 10.1002/mrm.26772
2. Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ROS-TXNIP-NLRP3 biological axis. Han Y et al. Redox Biol. 2018 Feb 15;16: 32-46. DOI: 10.1016/j.redox.2018.02.013
3. Mitochondrial abnormality facilitates cyst formation in autosomal dominant polycystic kidney disease. Ishimoto Y et al. Mol. Cell. Biol. 2017 Dec. 37: 24 e00337-17. DOI: 10.1128/MCB.00337-1
4. The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1. Xiao L et al. Redox Biol. 2017 Apr; 11: 297–311. DOI: 10.1016/j.redox.2016.12.022
5. Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes. Ward MS et al. Scientific Reports 2017. 7: 15190. DOI: 10.1038/s41598-017-15589-x
6. The swan-neck lesion: proximal tubular adaptation to oxidative stress in nephropathic cystinosis. Galaretta CI et al. Am J Physiol Renal Physiol. 2015 May 15;308(10): F1155-66. DOI: 10.1152/ajprenal.00591.2014
7. Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ. Dare AJ et al. Redox Biol. 2015 Aug; 5: 163–168. DOI: 10.1016/j.redox.2015.04.008
8. Contribution of mitochondrial function to exercise-induced attenuation of renal dysfunction in spontaneously hypertensive rats. Gu Q et al. Mol Cell Biochem. 2015 Aug;406(1-2):217-25. DOI: 10.1007/s11010-015-2439-6
9. Peroxynitrite induced mitochondrial biogenesis following MnSOD knockdown in normal rat kidney (NRK) cells. Marine A et al. Redox Biol. 2014; 2: 348–357. DOI: 10.1016/j.redox.2014.01.014
10. Preclinical evaluation of the mitochondria-targeted antioxidant mitoquinone to treat sepsis-induced acute kidney injury. Patil NK et al. FASEB J. 2013 27:1_supplement, 889.8-889.8 (LINK)
11. Prevention of diabetic nephropathy in Ins2+/−AkitaJ mice by the mitochondria-targeted therapy MitoQ. Chacko BK et al. Biochem J. 2010 Nov 15; 432(Pt 1): 9–19. DOI: 10.1042/BJ20100308
I hope this clarifies things for you and if there is anything further I can help with, please be sure to let me know.
Wishing you all good things
Ella"