3 replies to this topic

[Liaxx]

So I have been reading a lot about melanotan 2, having used it to get a tan in 2012.

Now I'm researching peptides that will whiten the skin and since melanotan 2 is a MC1R agonist, I figured that a MC1R antagonist will do the opposite, and lighten the skin. I found a MC1R agonist, MSG606. I also researched MITF inhibitors and found ML329. MITF regulates melanin in the skin.

My background in biochemistry isn't the best, so I might have interpreted those peptides and their research papers wrongly, but Prof. Victor Hruby, the researcher who first synthesized and researched Melanotan confirmed to me that MSG606, also synthesized by him, does affect pigmentation.

There is a big market for skin lightening out there, and it baffles me that those who would like to have lighter skin tones haven't gone the same route as melanotan and started injecting peptides. Is it because those peptides I mentioned can't alter pigmentation? Or what exactly.

Both peptides have been found around 2013.

What do you guys think?
 

[Mind_Paralysis]

Wrong forum mate.

 

This here is about brain health, you're talking about metabolism, complexion, appearance and such - it doesn't really have anything to do with things like Bromantane, NSI-189, Dihexa, and other nootropics, which is what we are discussing here.

 

 

My personal thoughts on this is that it sounds idiotic, unless you have some kind of genetic pigmentation disorder which either causes hyper or hypo -pigmentation. (something like vitiligo and lentigo)

[theobromananda]

Use MIF-1, it is a strong safe antidepressant.

[kurdishfella]

There are vitamin d receptor agonists  which directly activate the receptors which vitamin D does without all the process needed. So find the opposite a vitamin D receptor antagonist will make you lose a lot of melanin more than anything.  the enzymes limit how much nutrient  intake in to body  will be used if you produce low vitamin D due to genes then your body will just excrete the unneeded protein even if you are deficient. 

Edited by kurdishfella, 21 May 2022 - 09:34 AM.