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Will inhibiting MITF or MC1R lighten the skin?

skin peptides self experiment

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#1 Liaxx

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Posted 29 December 2018 - 01:25 PM


So I have been reading a lot about melanotan 2, having used it to get a tan in 2012.

Now I'm researching peptides that will whiten the skin and since melanotan 2 is a MC1R agonist, I figured that a MC1R antagonist will do the opposite, and lighten the skin. I found a MC1R agonist, MSG606. I also researched MITF inhibitors and found ML329. MITF regulates melanin in the skin.

My background in biochemistry isn't the best, so I might have interpreted those peptides and their research papers wrongly, but Prof. Victor Hruby, the researcher who first synthesized and researched Melanotan confirmed to me that MSG606, also synthesized by him, does affect pigmentation.

There is a big market for skin lightening out there, and it baffles me that those who would like to have lighter skin tones haven't gone the same route as melanotan and started injecting peptides. Is it because those peptides I mentioned can't alter pigmentation? Or what exactly.

Both peptides have been found around 2013.

What do you guys think?





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