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Beta Alanine raises Dopamine - worsened OCD?

beta alanine ocd obsessive compulsive disorder nucleus accumbens

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#1 Sascha100

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Posted 09 January 2019 - 08:51 PM


I suffer from OCD. This https://www.ncbi.nlm...pubmed/19543795 study seems to suggest it could raise dopamine in the nucleus accumbens in humans. Could this lead to any worsening of OCD symptoms? I already got this answer on reddit: "Based on that study on beta-alanine and some studies into the pathophysiology of OCD and drugs which can help treat it, it is possible that it could make OCD worse.

Antipsychotics (D2 antagonists) have shown some use in OCD individuals resistant to SSRI treatment, and their antipsychotic action at least is seemingly dependent on the nucleus accumbens. So perhaps by boosting DA in the NAc it could increase D2 activation and enhance obsessive symptoms, but these systems by no means exist in isolation so it may make it worse or it may make it better through other processes, and responses may vary between individuals -- the only way to find out is to try I suppose."

Any takes on that matter? I want a second opinion.

Thanks in regard,

Sascha from Germany



#2 Sascha100

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Posted 10 January 2019 - 05:42 AM

No one? :(



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#3 Sascha100

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Posted 10 January 2019 - 12:26 PM

That's very sad. I'd really love to take it and thought it would be harmless but it seems to have the potential to worsen it. If you search for OCD beta alanine you basically find no results at all but maybe it just isn't that well researched yet..



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#4 John250

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Posted 12 January 2019 - 09:36 PM

That's very sad. I'd really love to take it and thought it would be harmless but it seems to have the potential to worsen it. If you search for OCD beta alanine you basically find no results at all but maybe it just isn't that well researched yet..


I would try to find out the doses given to the mice in the studies and convert it to human doses. It would probably be an astronomical dose. There are a lot of supplements that could alter Neurotransmitters in astronomical dosing but not in standard dosing.




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