• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Beta Alanine raises Dopamine - worsened OCD?

beta alanine ocd obsessive compulsive disorder nucleus accumbens

  • Please log in to reply
7 replies to this topic
⌛⇒ support MITOMOUSE via LongeCity!

#1 Sascha100

  • Guest
  • 6 posts
  • 2
  • Location:Germany
  • NO

Posted 09 January 2019 - 08:51 PM


I suffer from OCD. This https://www.ncbi.nlm...pubmed/19543795 study seems to suggest it could raise dopamine in the nucleus accumbens in humans. Could this lead to any worsening of OCD symptoms? I already got this answer on reddit: "Based on that study on beta-alanine and some studies into the pathophysiology of OCD and drugs which can help treat it, it is possible that it could make OCD worse.

Antipsychotics (D2 antagonists) have shown some use in OCD individuals resistant to SSRI treatment, and their antipsychotic action at least is seemingly dependent on the nucleus accumbens. So perhaps by boosting DA in the NAc it could increase D2 activation and enhance obsessive symptoms, but these systems by no means exist in isolation so it may make it worse or it may make it better through other processes, and responses may vary between individuals -- the only way to find out is to try I suppose."

Any takes on that matter? I want a second opinion.

Thanks in regard,

Sascha from Germany



#2 Sascha100

  • Topic Starter
  • Guest
  • 6 posts
  • 2
  • Location:Germany
  • NO

Posted 10 January 2019 - 05:42 AM

No one? :(



sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#3 Sascha100

  • Topic Starter
  • Guest
  • 6 posts
  • 2
  • Location:Germany
  • NO

Posted 10 January 2019 - 12:26 PM

That's very sad. I'd really love to take it and thought it would be harmless but it seems to have the potential to worsen it. If you search for OCD beta alanine you basically find no results at all but maybe it just isn't that well researched yet..



⌛⇒ support MITOMOUSE via LongeCity!

#4 John250

  • Guest
  • 1,451 posts
  • 103
  • Location:Temecula
  • NO

Posted 12 January 2019 - 09:36 PM

That's very sad. I'd really love to take it and thought it would be harmless but it seems to have the potential to worsen it. If you search for OCD beta alanine you basically find no results at all but maybe it just isn't that well researched yet..


I would try to find out the doses given to the mice in the studies and convert it to human doses. It would probably be an astronomical dose. There are a lot of supplements that could alter Neurotransmitters in astronomical dosing but not in standard dosing.
  • Good Point x 1

#5 jack black

  • Guest
  • 1,286 posts
  • 41
  • Location:USA
  • NO

Posted 19 January 2019 - 06:38 PM

the few times I took beta alanine I felt no stim effects. i did have some faint face tingling, not sure why. i think this is harmless to try yourself, unless you're obsessively afraid to do it.


No one? :(

 

well, this forum is slow these days, looks like all the activity went to redit.
 



#6 Clavius

  • Guest
  • 46 posts
  • 3
  • Location:Netherlands
  • NO

Posted 21 January 2019 - 09:49 AM

the few times I took beta alanine I felt no stim effects. i did have some faint face tingling, not sure why. i think this is harmless to try yourself, unless you're obsessively afraid to do it.


 

well, this forum is slow these days, looks like all the activity went to redit.
 

 

That's a spiral. I myself went to reddit because nobody on this forum seemed to be interested in helping me out. Reddit is a dangerous source for information in this context though.



#7 AceNZ

  • Guest
  • 225 posts
  • 54
  • Location:New Zealand
  • NO

Posted 23 January 2019 - 01:25 AM

Dopamine is involved with two important processes in the brain. First, it creates the anticipation of a reward. Second, it provides the reward. People with OCD seem to have trouble processing the reward; they have the anticipation, but not the end result. When they anticipate a reward but don't get one, the anticipation doesn't go away, and tend to compulsively repeat the associated action.

 

This suggests that more dopamine in the brain of people with OCD *might* not be a good thing. If it only increased the anticipation signals, compulsions would be worse. However, if it managed to increase reward signals, OCD could also improve (in theory).

 

There's a related theory I recall reading that high dopamine levels in brain synapses can cause the number of receptors to decrease. Again, whether that's a good thing or not "depends."

 

The effect on specific individuals is difficult to predict, and may well vary based on genetics and a host of other factors. If it was me, and I was well enough to be able to tolerate some experimentation, Beta Alanine is the kind of thing I might try. Very personal / individual decision, though.

 



sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#8 jack black

  • Guest
  • 1,286 posts
  • 41
  • Location:USA
  • NO

Posted 24 January 2019 - 02:59 PM

you might be right, OCD people may be high in dopamine and low in 5HT.






0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users