Posted 26 January 2019 - 11:41 PM
I'd be interested to hear other's experiences and views on the difference between Ubiquinol and Ubiquinone.
Apparently Ubiquinol is more available to the body, yet I can take 200mg of it and not notice very much. If I really need some energy, particularly if
I haven't slept, or have a long day ahead, I find Ubiquinone, at a lesser dose of only 60mg really helps.
Anyone else noticed this, or know why? Recent literature states ubiquinol is better (it's also more expensive right now).
thanks :-)
Posted 15 February 2019 - 12:26 AM
I've taken both over extended period. I feel nothing with it/without it/or in it's different forms. It's all on faith in science that it has good effect.
Interesting. For me there's definitely an effect, but then I'm on beta blockers at the moment, and have a lot of fatigue. I also have hypothyroidism....although it's treated...........all I know is whenever I take the Q10 form, I feel much better..........yet the Ubiquinol is supposed to be the better form.
Someone said it might be the brand that is more relevant.......but pretty sure I've taken the same brand and still not noticed much with ubiquinol. I think I'll listen to my body and energy levels on this one and take the Q10
Posted 15 February 2019 - 12:33 AM
I notice much more of a difference from ubiquinol than coq10 but I take 200-300 mg preworkout. I never sweat when on it and have far more energy.
Thanks. I might try a different brand of ubiquinol once more in view of this.
Posted 15 February 2019 - 06:45 AM
Ubiquinone is the oxidized form of CoQ10. Ubiquinol is the reduced form. The body can easily transform one into the other.
Some people seem to respond to one version better than the other. The exact reasons are unclear. It may be more related to brand or manufacturing processes than being oxidized vs. reduced. Also, because Ubiquinol is reduced and most gelcaps aren't impervious to oxygen, it's a manufacturing challenge to keep Ubiquinol from changing into Ubuiqinone in the capsule, before you even swallow it.
Most studies have been done with Ubiquinone. Based on that and the fact that it's much less expensive, that's what I use and recommend. If someone has a tolerance problem or a failure to respond as expected, I would first suggest trying another brand. Only then, if there are still problems, would I suggest trying Ubiquinol.
Posted 15 February 2019 - 10:34 AM
Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone.
The bioavailability of the reduced form of coenzyme Q10 (ubiquinol) was compared to oxidized coenzyme Q10 (ubiquinone) with identical soft gel capsule excipients by measuring steady state plasma coenzyme Q10 (CoQ10 ) levels in 12 healthy volunteers. After baseline levels of ubiquinol, ubiquinone, total CoQ10 , α-tocopherol, and total cholesterol were obtained, follow-up lab work was performed after 4 weeks of 200 mg/day of ubiquinone, after 4 weeks washout, and after 4 weeks of 200 mg/day of ubiquinol. Plasma total CoQ10 increased from 0.9 to 2.5 µg/mL (P < 0.001) after 4 weeks of ubiquinone and increased from 0.9 to 4.3 µg/mL (P < 0.001) after 4 weeks of ubiquinol. Total CoQ10 /cholesterol ratio increased from 0.2 to 0.7 µmol/mmol after 4 weeks of ubiquinone and increased from 0.2 to 1.2 µmol/mmol after 4 weeks of ubiquinol. Both the increase in plasma CoQ10 and the increase in CoQ10 /cholesterol ratio were significantly better after ubiquinol (P < 0.005 and P < 0.001, respectively) than after ubiquinone indicating superior bioavailability. Plasma ubiquinol/total CoQ10 ratio increased from baseline during ubiquinol supplementation (P < 0.005) and remained unchanged after ubiquinone supplementation. No side effects were noted in this study.
© 2013, The American College of Clinical Pharmacology.
Also:
Coenzyme Q10 (CoQ10) exerts its functions in the body through the ability of its benzoquinone head group to accept and donate electrons. The primary functions are to relay electrons for ATP production in the electron transport chain and to act as an important lipophilic antioxidant. Ubiquinone, the oxidized form of CoQ10, is commonly formulated in commercial supplements, and it must be reduced to ubiquinol to exert CoQ10's functions after consumption. Thus, we aimed to examine whether as compared to ubiquinone, ubiquinol would be more effective to enhance the CoQ10 status in older men. We conducted a double-blind, randomized, crossover trial with two 2-week intervention phases and a 2-week washout between crossovers. Ten eligible older men were randomized to consume either the ubiquinol or ubiquinone supplement at a dose of 200 mg d-1 with one of the main meals. A total of 4 blood samples were collected after an overnight fast for the determination of ubiquinone and ubiquinol in plasma and PBMC and the assessment of FRAP, total thiol, and malondialdehyde (MDA) in plasma and ATP in PBMC. After 2 weeks of the supplementation, the ubiquinol supplement significantly increased plasma ubiquinone 1.7 fold from 0.2 to 0.6 μmol L-1 and total CoQ10 (the sum of 2 forms) 1.5 fold from 1.3 to 3.4 μmol L-1 (p < 0.05) and tended to increase the plasma ubiquinol status 1.5 fold from 1.1 to 2.8 μmol L-1, but did not alter the ratio of ubiquinol to total CoQ10. The ubiquinone supplement insignificantly increases plasma ubiquinol, ubiquinone, and total CoQ10 and did not affect the ratio. Of 10 subjects, six were more responsive to the ubiquinol supplement and 2 were more so to the ubiquinone. The supplementation of both CoQ10 forms did not alter the CoQ10 status in PBMC. FRAP, total thiol, and MDA in plasma and ATP in PBMC were not changed during the intervention. The significant increase in plasma CoQ10 status observed after the 2-week supplementation suggested that ubiquinol appeared to be a better supplemental form to enhance the CoQ10 status than ubiquinone in older men. Neither ubiquinol nor ubiquinone supplement affected the measured biomarkers of oxidative stress.
coenzyme Q10; plasma level; supplementation; ubiquinol; ubiquinone
Edited by Benko, 15 February 2019 - 10:39 AM.
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