6 replies to this topic

[SB_UK]

Hello.

Apart from fasting (and the mechanisms which're recruited in fasting) - are there any other proven (not controversial) interventions to increase longevity in the eukaryote (yeast cell upwards) ?

I'm not looking for any factors which're recruited in fasting.

Thanks, SB.

Edited by SB_UK, 30 January 2019 - 08:10 AM.

[SB_UK]

Linking here to the only model that I can see of overcoming ageing (an incapacitated stage prior to physical death).

Longecity link
So - connecting the longevity on Mount Athos (eg  'They also live an average of 10 years longer' from eg) and the Naked Mole Rat ... ... ... would be metabolism.

Ketogenic lifestyle (performed in a certain way) can get us there.

Accessed through development of conscience (ethical nature).

And then developed through acquisition of personal excellence (in some neocortical attribute).

 

So - ketogenic state supports the 'learning zone' ie results in a metabolic state which supports leanring (neural rearrangement as opposed to cell division (growth generally).

 

IE ToR not IIS for learning.

 

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Let's take it further.

 

Once all of the above is followed - how can we maximize/increase longevity ?

 

We're time-limited by number of heart beats.

We're actually on the clock - but can get HR down using known interventions - eg eliminate adverse stress + HIIT.

 

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What about living for EVEN longer ?

Let's do all that we can and then see what happens.

 

I don't have any ideas on extension beyond the ideas above of ketogenic shift + drop in resting heart rate.

But it is often said that death makes life meaningful.

 

I have no problem with this statement - have a problem ONLY with disease destroying the finite lifespan we're granted.

Edited by SB_UK, 31 January 2019 - 07:41 AM.

[SB_UK]

Let's try and bring things together and then peer into the future
 

1. Planck time was the first Universal structure (see Stephen Hawking)
2. The Universe consists of structures which're synchronized a bit like musical instuments in an orchestra - the reason why pulsars are Planck time accurate.

3. The synchrony plays out in man - with man offered (in effect) a fixed number of heart beats.

4. Now - we can reduce our resting heart rate through avodance of distress  (yes your boss at work is killing you) and HIIT.

5. The heart beat pumps oxygen around our body.

6. Presumably reducing the need for the body to obtain oxygen would  be useful in increasing longevity.

7. A tempting thought - but if we sit very still (etc) - then we become bored - there're 2 'distress' zones around a eustress zone for optimal human longevity or in plain English too little / too much kills us - with intentional reference to the Middle Way.

8. Now let's look at the Industrial -> Informational revolution in society in effect from heavy energy to light energy usage - which we need mimic in man.

9. A shift from the body working to the mind working is the basis to the Industrial -> Informational revolution in man.

10. Note though that the mind still requires ATP indirectly through cost of neural action potential generation.

11. So - our 'happy' place is a place of learning (eg the creation / appreciation or motor / sensory cortex) of information recognition (cerebellum).

12. The brain will require energy - and there's nothing that we can do about that - however we do know that the brain is awfully keen on ketones.

 

--- Now entering science fiction ---

 

13. Melanin can transduce energy from the electromagnetic spectrum in the absence of oxygen ie see radiotrophic fungae and particularly those that grow in space.
There's a direct mechanism of EM energy -> acetate (feeding mitochondria) in radiotrophic fungus.

14. A key path in the naked mole rat towards longevity is via fructose obviating the need for oxygen in operation - and a key part of my presentation is the use of inulin (oligofructose) through gut fermentation.

 

What am I suggesting ?

That the fixed number of heart beats can be reduced (slowed incredibly cf naked mole rat) by a few simple interventions currently.

A shift into the learning zone brings down peripheral/central oxygen requirements further.

 

However - that we're fairly close to reducing oxygen requirements yet further with a form of mitochondrial photosynthesis alongside gut biome soluble fibre/prebiotic/inulin fermentation process.

We can't do anything about 'being on the clock' - however may be able to slow the clock beat down to very slow indeed.

 

The first part of the idea can be handled by lifestyle change - lots of proven interventions in reducing heart rate - particularly like the idea of altitude training for instance.

 

The second part - will need to occur with actual evolutionary shift.

 

Do we want to live for longer ?

Well - not currently - life is akin to living within a zombie apocalypse with every person we pass trying to bite off our heads (steal our wallets).

 

However with an understanding that we've moved past materialism -> that we've moved past Understanding of context (the evolutionary mechanism of generalized Theory of Everything) -> into personal neural/psycho quality
- there is hope that people may want to live for longer.

 

Life need not be painful.

Edited by SB_UK, 31 January 2019 - 10:42 AM.

[SB_UK]

So - not so surprising that we've a fixed number of heart beats (give or take), not surprising that reducing demand for oxygen reduces supply (the one rule of economics!) - however we need to work out how to reduce demand right down to reduce supply.
We need to work out a way of radically eliminating oxygen need.

The 2 systems where this has been proven is in radiotrophic fungae and the naked mole rat - both mechanisms should be open to us - and soon.

Now shifting into personal intuition.

My favourite 2 things are sun (high UV) and garlic (raw) - one of the top three inulin containing foods.

Sun and Garlic - both easy to source - garlic easy to grow.


I'm looking at a mechanism by which melanin can harness UV (down from gamma ray) - and in which neuromelanin is pivotal in the conversion.
I'm looking at a mechanism whereby the gut biome assists ?? in supplying fructose to a repurposed glycolytic system and assists us in energy generation minus oxygen.
http://science.scien...nt/356/6335/307

Note - none of this is to get us off the planet - and it's all just to reduce heart rate - the rule of the manifest Universe is that we're synchronized on time - can not escape time. Enjoy your time - and that won't matter though.

So - pulsar beat is much slower than Planck time but is perfectly synchronized - the same principle applies.

[SB_UK]

Closer
https://scienceline.....n-outer-space/
 

Quote:

...radiation splits and super-charges water molecules creating a variety of highly reactive particles, including a toxic form of oxygen known as superoxide.

https://en.wikipedia...oxide_dismutase

Quote:

SODs catalyze the disproportionation of superoxide:
2 HO2 → **O2** + H2O2

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Back on-line ... ... getting closer - we'll regenerate oxygen from water. And oxygen back into water as the little discussed end-point in the mitochondrial ETC.


https://en.wikipedia...transport_chain

NADH+H+ → Complex I → Q → Complex III → cytochrome c → Complex IV → **H2O**
......................↑ Complex II
......................↑ Succinate

-*-

True elegance

O2 <-> H20

Edited by SB_UK, 31 January 2019 - 11:34 AM.

[SB_UK]

radiation via melanin -> acetate accumulation (see radiotrophic fungus paper, PLOS)

radiation + H2O -> Superoxide free radical production + dismutase -> O2 + acetate via Mitochondrial electron transport chain -> H20 + ATP

 

{{{ H2O -> O2 -> H2O }}}

 

So - the point of this comment is to provide the mechanism of shifting us away from the need to breathe / heart rate reduction as limiting towards increasing happy healthy longevity.

The mechanism's elegance defines it as definitely correct.

Nature has elegance built in.

 

-*-

 

The ending makes sense cf UV ("Exposure to UV radiation is the main factor that causes skin cells to become cancer cells" -- google ie superoxide formation resulting in adverse outcomes under the IIS model and not the ToR model of metabolism) ... ... ... next to no cancer in the VERY sunny Mount Athos where fasting (ToR) is routine.
And of course UV may be sensed by melanin (as we tan).

But but but ... ... ...  

Edited by SB_UK, 31 January 2019 - 11:58 AM.

[SB_UK]

Note - the emphasis isn't on removing oxygen but removing the need for the heart/circulatory system to work to deliver oxygen -> reduced heart rate -> increased longevity.
Oxygen remains an important part of the equation.

 

Edited by SB_UK, 31 January 2019 - 11:55 AM.