5 replies to this topic

[Phoebus]

 

What about tau? Because APP/PS1 mice develop little tau pathology, Bohr and colleagues turned to 3xTg AD mice, which carry a tau mutation on top of APP and PS1 mutations, and form tangles. Treating them with urolithin A for one month inhibited tau phosphorylation and restored memory in the Y maze and object recognition tests. Intriguingly, previous research from Eva Mandelkow at the German Center for Neurodegenerative Diseases in Bonn found that a tau kinase, MARK2, also regulates PINK1 and mitochondrial transport (Matenia et al., 2012). Bohr noted that in AD, tau pathology associates more closely with cognitive decline than amyloid does, suggesting that targeting tau pathology by boosting mitophagy could help patients.

 

Bohr and colleagues are testing this in a clinical trial run by Steen Hasselbalch at Copenhagen University Hospital, Denmark. AD patients will take nicotinamide riboside, a Vitamin B3 variant that boosts nicotinamide adenine dinucleotide (NAD+). NAD+ precursors are known to stimulate mitophagy. Bohr said an advantage of this dietary supplement is that it has few side effects. NAD+ precursors are beginning to be evaluated for neurodegenerative and other conditions.

Besides testing nicotinamide riboside in people, Bohr plans to further dissect how tau and mitochondria interact in worms. Prior studies have blamed abnormal tau for instigating mitochondrial dysfunction (Manczak and Reddy, 2012; Duboff et al., 2013; Eckert et al., 2014). 

 

 

https://www.alzforum...heimers-disease

 

EDIT

 

actually a closer reading shows they will actually test it on people currently diagnosed with AD 

 

This is wow. If this trial shows NR effective against AD, expect this stuff to explode. 

Edited by Phoebus, 17 February 2019 - 07:40 PM.

[Harkijn]

About boosting mitophagy there is this interesting recent study. It may have gone under the radar sofar because it is a murine study and concerned with recovery from chemotherapy and irradiation. However the reserchers claim to have a first in proving that boosting NAD  improves mitophagy and the regeneration of hematopoetic stem cells. Which of course interests all of us.

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.

https://www.ncbi.nlm...pubmed/30849366

[Daniel Cooper]

Do we have a thread that is a summary of all NAD+ related human studies?  That seems like it would be a good idea and perhaps it should be limited to just published results.  I find it difficult to keep up with what's proposed, what's in progress, and what's actually completed wrt to NAD+ human studies.

 

 

 

[Phoebus]

About boosting mitophagy there is this interesting recent study. It may have gone under the radar sofar because it is a murine study and concerned with recovery from chemotherapy and irradiation. However the reserchers claim to have a first in proving that boosting NAD  improves mitophagy and the regeneration of hematopoetic stem cells. Which of course interests all of us.

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.

https://www.ncbi.nlm...pubmed/30849366

 

 

from the study 

 

 

 

Here we show that the NAD+-boosting agent nicotinamide riboside (NR) reduces mitochondrial activity within HSCs through increased mitochondrial clearance, leading to increased asymmetric HSC divisions.

 

 

 

what is 'increased mitochondrial clearance'  and why does it lead to increased asymmetric HSC divisions?

 

Is  'increased mitochondrial clearance'  the same as saying an increase in mitophagy? 

Edited by Phoebus, 21 March 2019 - 09:18 PM.

[bluemoon]

Do we have a thread that is a summary of all NAD+ related human studies?  That seems like it would be a good idea and perhaps it should be limited to just published results.  I find it difficult to keep up with what's proposed, what's in progress, and what's actually completed wrt to NAD+ human studies.

 

I made this list last year:

 

https://www.longecit...es-in-mid-2018/

 

More trials:  

 

* NR for Brain Health (Bioenergetics), McLean Hospital, n = 60, 1,000 mg of NR, study ends in July 2019.

 

* Basis: Evaluating Sirtuin Supplements To Benefit Elderly Trauma Patients, U. of Pennsylvania, n = 48, 500 mg NR and 100 mg of pterostilbine (2x a day), study ends in January 2020. 

 

* NR and CoQ10 for Chronic Kidney Disease, U of Washington, n  = 30, 1,000 mg of NR and 1,000 mg of CoQ10 for 6 weeks, study ends April 2020.

 

* NR and Pterostilbine on Muscle Regeneration in Elderly Humans, U of Copenhagen, n = 30, 500 mg of NR and 100 mg of pterostilbine (2x a day), study ends in July 2020.  

 

* NR for Early Parkinson's Disease, Haukeland University, n = 200, 1,000 mg of NR for 52 weeks, study ends in October 2021.

 

* NR in Chemo-induced Peripheral Neuropathy, NCI, n = 39, 300 mg NR then 1,000 mg, study ends in April 2022.

 

* NR for for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment, U of Delaware, n = 58, 250 mg (4x a day), study ends in March 2022.

 

 

https://www.aboutnad...linical-trials/

Edited by bluemoon, 26 March 2019 - 02:07 PM.

[bluemoon]

Not many trials have been published on humans yet. Chromadex's 140 person study with 100 mg, 300 mg and 1,000 mg of NR and a control placebo still hasn't been published 2 years after the trial ended but their science adviser, Charles Brenner, said a few weeks ago it will be published "soon" which I assume means by summer if not earlier.

 

Elysium's Basis showed an 8% improvement in a 6 minute walking test and an 8% improvement on a balance test at 500 mg of NR and 100 mg of pterostilbine after 8 weeks but no improvement with 250 mg of NR and and 50 mg of pterostilbine.

 

A U of Colorado Boulder study of 24 participants taking 1,000 mg of NR or a placebo showed a 10 point improvement in some with pre-hypertension and arteries were less hardened but I'm not sure by how much.

 

There is apparently no effect of NR on blood glucose levels.

 

There are indications that over 500 mg of NR taken daily for weeks decreases fatty liver by 10% to 20%.