12 replies to this topic

[MankindRising]

Now, I have resveratrol en route (iherb shipping slow now, arriving start/half februari at my place). So I thought id eat lots of grapes to get an indication of how resveratrol feels like.

Before anyone says placebo, it does seem to have clear cut antidepressant effects in every model of depression and stress.

 

Peaks at 1-3hour post dose, but even after that it seems to last and drift into the next day.

 

Anyone else that has depression noticed this from resveratrol?

 

FYI I have been on SSRI's in the past and I notice some similarities, however resveratrol seems to have a distinct pro-love/oxytocin like effect to it. Oddly I also noticed some anticipatory anxiety when simply walking on the street.

Now resveratrol is PDE4i, this could potentiate beta adrenergic signalling through cAMP.

 

edit heres an example, there are more but i simply cba atm:

https://www.longecit...social-effects/

Edited by MankindRising, 18 February 2019 - 06:06 PM.

[Mind]

100 grapes per day (5 grams per grape)? Maybe you are just happy from the gargantuan amounts of sugar contained in that many grapes.

[MankindRising]

100 grapes per day (5 grams per grape)? Maybe you are just happy from the gargantuan amounts of sugar contained in that many grapes.

Ive used over 100+ substances (both herb and pharma), I can feel when something is doing something. Also the effect suddenly 'pops up' T+1-3hours after eating them, which is in line with maximum concentration of resveratrol found in plasma in human studies.

Yeah Im aware of the amount of sugar (well fructose) in it, however drinking the same amount of carbs in the form of lemonade does nothing to me.

I do have mito dysfunction though and ADHD/ASD, theres tons of studies out there recently about resveratrol and ptero having an effect on innate immunity, inflammation and paravalbumin problems in ASD. Also resveratrol seems to enhance pCREB in the amygdala and PFC similar to SSRI's.

 

Btw I have used GSE (grape seed extract) and pycnogenol in the past and the effect was no way close to this.

 

Resveratrol suppresses neuroinflammation in the experimental paradigm of autism spectrum disorders.

https://www.ncbi.nlm...pubmed/28025035

 

Resveratrol Prevents Cellular and Behavioral Sensory Alterations in the Animal Model of Autism Induced by Valproic Acid.

https://www.ncbi.nlm...pubmed/29872390

"Our data showed for the first time an altered localization of PV+-neurons in primary sensory cortex and amygdala. We also showed a reduced level of gephyrin in the primary somatosensory area (PSSA) of VPA animals. The treatment with RSV prevented all the aforementioned alterations triggered by VPA. Our data shed light on the relevance of sensory component in ASD and highlights the interplay between RSV and VPA animal model as an important tool to investigate the pathophysiology of ASD."

 

Resveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERβ activation

https://molecularaut...3229-018-0225-5

ERβ is needed for oxytocin transscription btw

 

 

Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex.

https://www.ncbi.nlm...pubmed/26801825

 

Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway

https://www.frontier...2016.00044/full

 

"RES-treated rats showed increased rearing frequency and distance in the open-field test, increased sucrose preference in the sucrose preference test, and decreased immobility in the forced swimming test compared with SCH rats."

 

Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats.

https://www.ncbi.nlm...pubmed/24503118

"All of these effects of resveratrol were essentially identical to that observed with the established antidepressant, desipramine. In conclusion, our study shows that resveratrol exerted antidepressant-like effects in CUMS rats, mediated in part by normalizing serum corticosterone levels while up-regulating pERK, pCREB and BDNF levels in the hippocampus and amygdala."

 

 

Also obviously resveratrol increases autophagy and inhibits mTOR which is considered extremely beneficial in ASD. Theres an endless amounts of studies backin up its anti-anhedonia effect btw on top of that theres more users reporting it on longecity. Im just surprised by the extremely small quantities of resveratrol must be in 500gram worth of grapes, I mean I can see how the supp can make me manic.

FYI Im subclinical hypothyroid (tsh antibodies, autoimmune and using levothyroxine for it).

Edited by MankindRising, 18 February 2019 - 06:39 PM.

[Kimer Med]

Might be the Resveratrol, but there are a bunch of other phytonutrients in dark grapes, too, such as catechins, anthocyanins, polyphenols, and flavonols (not to mention the sugar) -- and a correspondingly broad set of biological effects.

 

You might try taking Trans-Resveratrol caps, and see if it causes the same effect. Measuring your blood glucose after eating the grapes would be interesting, too.

 

[MankindRising]

Day 3, ate 500gram grapes together with breakfast and T+3hours got a profound change of personality and mood (for the better). It must be one of the metabolites or something that does.

Its acting like a full blown antidepressant in me, im very surprised how powerfull it seems to be.

 

Once my 200mg resveratrol pills (98% pure emodin free n that lot) arrive im considering taking only a 10th of the capsule at first. Ordered this product btw: https://nl.iherb.com...ggie-Caps/77938

States its without emodin and without polyaromatic hydrocarbons.

 

Once again ive used a lot of meds/herbs including memantine, so I know when something is doing something. Id rate the mood effects on par with memantine, however I suspect my profound reaction to the grapes (and most likely the resveratrol content) also has to do with the fact that I have both ASD and subclincal hypothyroidism (resveratrol seems to improve social deficits and depression in both models).

 

Let me put it like this, if theres going to be no tolerance to the effects of resveratrol I think I have found my 'cure'. I feel so much more outgoing on this, its a day and night difference.

What strikes me is the fact that my anticipatory anxiety (lost over 15 years ago) has now returned! and the anhedonia has nearly fully disappeared.

 

Btw my pupil size seems a lot bigger on resveratrol than it normally is average (even in sunlight).

Edited by MankindRising, 19 February 2019 - 03:16 PM.

[MankindRising]

Update.

 

Day 5, the effect is still happening, could feel it today at T+2.5hours.

 

Some other things Ive noticed:

 

* STOOL COLOR: normally is always very dark/close to black (no blood though), but heavily constipated and rabbit poop clumped (odd but best way to describe it). The grapes seem to completely get rid of this, stool color is now medium range brown and normal soft texture (looks like it contains more fluid). The difference is night and day regarding this.

* emotional bouts, more likely to have tearfull episodes and daily events seem to be given an emotional meaning instead of being pure raw data like it was in the past to my autistic brain. FYI I class this beneficial, as its not just teary responses but also positive emotions seems to amplified.

* SKIN: much more smooth and more 'tight', Allthough this is an early call, I will keep monitoring this.

* Gut distress: nearly completely gone, no more instant farting upon the smell of cigarette smoke or other chemicals (resveratrol is an AHR antagonist, I wonder if this is succesfully modulating my genetic aromatic hydrocarbon response (I do have 1 slow CYP1A2 enzyme according to 23andme btw).

 

Not sure if the grape type is going to matter (doubt it), but ive been using 'Tawny' and 'Evans Delight'

Seems to beat biogaia gastrus so far for me.

 

Will keep updated.

Edited by MankindRising, 21 February 2019 - 11:27 AM.

[MankindRising]

Might be the Resveratrol, but there are a bunch of other phytonutrients in dark grapes, too, such as catechins, anthocyanins, polyphenols, and flavonols (not to mention the sugar) -- and a correspondingly broad set of biological effects.

 

You might try taking Trans-Resveratrol caps, and see if it causes the same effect. Measuring your blood glucose after eating the grapes would be interesting, too.

Dont have a glucose meter at home.

How accurate are these home devices, would like some info on prices (not looking to spend a lot) and accuracy. Also most work with strips dont they?

FYI: I get blood drawn routinely and my HBA1C and fasting glucose are always good.

 

I do seem to have a genetic lipid problem though as my triglycerids are always BELOW range and stuff like l-carnitine seems to increase cyst growth in me. Had one on my back that was removed by surgery and was left with some ugly scar tissue. Then later on started with l-carntine again (for my ASD) and voila regrowth on the same spot (literally pushed through the scar tissue) and theres a new smaller cyst now. Seems my body cant handle too much triglycerids in the blood, same happened with PQQ (which mildy increase triglycerids in the blood) and alpha gpc (dumps fatty acids in the blood). My body seems to not able to handle triglycerids in the blood too much, forcing triglycerids in the bloodstream seems to be bad for me.

Also got a rare il-6 gene according to codegen.eu

 

Btw that 'mutation' is associated with hashimotos thyroid problems, which I think I do have (elevated TSH and subclinical hypothyroidism and elevated TSH antibodies).

Doctors underestimate the power of genetic accuracy imo, especially with regards to immune alterations.

 

Theres 2 studies on resveratrol (in animals) showing quite powerfull benefits on subclinical hypothyroidism (including the depressive symptoms associated with it):

 

Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway (intragastric injection)

https://www.frontier...2016.00044/full

 

resveratrol beating levothyroxine in lowering TRH expression: https://www.frontier...-00044-g002.jpg (close to completely normalizing expression)

tsh, t4 and t3 alterations during resveratrol: https://www.frontier...-00044-t001.jpg

 

15mg/kg, I weigh 92kilo and done in rats, so would correspond to a human dose of 210-220 mg (ordered 200mg pills)

 

 

Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization

https://doi.org/10.1...docrj.EJ15-0253

 

https://ibb.co/VBWcTw0

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Edited by MankindRising, 21 February 2019 - 12:07 PM.

[Kimer Med]

Dont have a glucose meter at home.

How accurate are these home devices, would like some info on prices (not looking to spend a lot) and accuracy. Also most work with strips dont they?

FYI: I get blood drawn routinely and my HBA1C and fasting glucose are always good.

 

Home blood glucose (BG) meters are accurate and relatively inexpensive. Yes, they use strips (one per test). To use: clean your skin with an alcohol wipe, put a test strip in the meter, use a spring-loaded needle to poke a small hole in your skin, squeeze a tiny drop of blood out of the hole, hold the tip of the test strip (still in the meter) to the drop of blood so that it's brought into the strip by capillary action, and then wait a few seconds for the result. I haven't used this particular brand, but here's an example inexpensive starter kit that includes some test strips:

 

https://amzn.to/2NgPtP8

 

Fasting BG and HbA1C are good checks for diabetes or pre-diabetes. What I was suggesting is something different: check to see if the improvement in mood you've noticed is correlated with a short-term increase in BG from the grapes. If BG stays level or decreases while you're feeling positive effects, that would suggest that the cause is from something other than the fruit sugar (fructose) -- such as Resveratrol or one of the other phytonutrients.

 

Since you brought up triglycerides, it's also worth noting that fructose is directly converted into triglycerides by the liver -- so another possible interaction there.

[MankindRising]

Home blood glucose (BG) meters are accurate and relatively inexpensive. Yes, they use strips (one per test). To use: clean your skin with an alcohol wipe, put a test strip in the meter, use a spring-loaded needle to poke a small hole in your skin, squeeze a tiny drop of blood out of the hole, hold the tip of the test strip (still in the meter) to the drop of blood so that it's brought into the strip by capillary action, and then wait a few seconds for the result. I haven't used this particular brand, but here's an example inexpensive starter kit that includes some test strips:

 

https://amzn.to/2NgPtP8

 

Fasting BG and HbA1C are good checks for diabetes or pre-diabetes. What I was suggesting is something different: check to see if the improvement in mood you've noticed is correlated with a short-term increase in BG from the grapes. If BG stays level or decreases while you're feeling positive effects, that would suggest that the cause is from something other than the fruit sugar (fructose) -- such as Resveratrol or one of the other phytonutrients.

 

Since you brought up triglycerides, it's also worth noting that fructose is directly converted into triglycerides by the liver -- so another possible interaction there.

Actually started yawning a couple of times and this comes a long with ass odd as it may sound... random boners... (so im guessing this is an oxytocic/dopaminergic effect rather than a drop in blood glucose?). FYI when I feel far more mentally sane and feelings of openness. A strong shift from negative perception of future events towards the positive. I wonder if its due to brain estrogenic effects that resveratrol can have.

Either way the effect im getting from the grapes is extremely profound, it just 'hits me' 1-3hours after intake. And looking back to a week ago, it seems like theres a small buildup effect.

As crazy as it may sound I feel like im finally conquering my anhedonia (panax ginseng was very mild compared to this in the past). Also I prefer this effect over memantine, which did have mood lifting properties but it was 'too forced' and had distinct drug like effects. The grapes feel so natural.

Btw during the yawning Im not tired at all, either way I will grab a blood glucose machine somwhere in the future but not within a month since I gotta buy a new washingmachine and a bunch of other stuff which have priority atm.

 

Either way I seem to fit the perfect bill for resveratrol to be efficient in me:

autism/asd/adhd

gut problems

(suspect) mito dysfunction

subclinical hypothyroidism

autoimmunity

[MankindRising]

Day 6.

 

The effect is still there, always at T+2-3hours it hits me and then gradually stays the same for over the course of 4-5 hours and then it drops off.

Couple of things Ive noticed:

 

* going to bed EARLIER since the last few days, normally I keep going to bed at 2am, but Ive noticed that Im now down to going to bed at like 11.45pm, which is remarkable since Ive had circadian dysruption pretty much all my life. SIRT1 inducers in the morning (according to selfhacked) apparently can reset circadian rythm and I did found some studies showing resveratrol can alter clock/bmal1 gene expression

* bouts of aggression (due to emotions amplification), more likely to stand up for myself and get what I want (even at the costs of others).

* energy energy energy and NO more crashes (the other day I had to yawn like crazy, I guess resveratrol is adjusting my insulin sensitivity?)

* also considering the role of insulin sensitivity on serotonin function, the effect that the grapes are having on me is beyond my expectations

* increased imagination and anticipation (this is big), phosphatidylserine gave me bouts of dejavus in the past but it was always regarding past experiences. the grapes seem to increase my FUTURE anticipation.

 

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

https://doi.org/10.1...CI.0385-14.2014

Remarkably the study also showed INCREASED leptin in resveratrol individuals, every other adaptogen and herbal usually seems to do the oposite? Ive always thought that lowering leptin was beneficial.

 

 studies have shown resveratrol can increase functioning connectivity, ive used psilocybin months ago in microdoses btw, I know when something is doing something to my brain.

* skin tightness in the face, eyes appear more wide open, people sometimes look at me as if im on drugs, pupil size still enlarged.

* I seem to eat more and wake up slim as hell, is it possible its allready having an effect on my body comp?

* stool! going to the toilet is a 5second thing, no more dark colored stools, no more rabbit like bricks that are clumped together, its brown, soft, none-rocky and far more moist now.

* a weird one: I noticed I started blushing/feeling shame again! as weird and odd as it might sound I know this might be adrenalin related

* more prejudice towards people (estrogen receptor activation upregulating my oxytocin??)

Edited by MankindRising, 22 February 2019 - 08:04 PM.

[MankindRising]

Day 7+8:

Ive been waking up earlier and earlier (also gone to bed a bit earlier, I feel as if I need less overall sleep though). From the moment I wake up I am awake like no other. Normally I always need a hot shower first for what I suspect is early arthritis symptoms with general stiffness and body aches, this is barely present anymore.

The effect seems to have turned into some kind of antidepressant like activity, looking back over the last 2 days, my interest in women is 'different' in a way thats more romantic but less typical male libido. IDK could be in my head but theres some anadetocal evidence/replies from others (including on this forum) regarding resveratrol lowering libido in them.

Some thing else I should add:

Im getting an increase in motivation, this seems to be different from the regular dopaminergic effects Ive had from ritalin and all that. Instead I seem to find the things that I want to achieve itself more important than before, hard to describe. Ritalin used to make me motivated without feeling a reason why Im actually even doing a particular task, this is not the case at the moment. Its as if it gives me insight in why I have to do the task. I wonder if it has to do with the functional connectivity increase that resveratrol can give.

Edited by MankindRising, 24 February 2019 - 08:07 AM.

[MankindRising]

Update day 9+10.

 

Im still getting the effect, it always hits me at T+3 hours (which is when the sulfate and gluconate form of resveratrol have peak plasma activity).

No joint pain, but I do get nausea for about 30mins shortly after taking the grapes (which is transient and mild).

Other than that, definetely an antidepressant effect in me. I find myself taking a lot more risk too. More focus too which is possibly due to autophagy activating synaptic pruning. Normally my brain goes haywire and theres a million thoughts running through my mind and not excuting or choosing a thought. Lack of filter for sure normally without the grapes.

Also pupil size is up up up up!!! I do look a little drugged up if I look into my own eyes in the mirror like as if im on some acid or molly.

 

Another thing: I am still going bed earlier and also waking up earlier, it seems to be very beneficial for my sleep cycles (and I seem to have slightly less total sleep time, but much maybe 10-15mins at most).

Edited by MankindRising, 26 February 2019 - 04:47 PM.

[MankindRising]

Update day 13,14,15:

 

I am still getting this effect!!! what the hell is going on!, Literally always T+3hours after intake.

I need some help figuring out what this might be due to.