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Study shows Nicotinamide Riboside boosts Exercise Performance in Older Adults

nad+ nicotinamide riboside exercise older humans

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#1 Engadin

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Posted 06 March 2019 - 05:49 PM


exercise.jpg

 

Previous studies have demonstrated that NAD+ levels fall as we age. Studies have also indicated the important role of NAD+ in keeping the body healthy and vital. It has therefore been long suspected that aging individuals and elderly would benefit most from supplementing NAD+ pre-cursors in order to boost NAD+ levels.

In this study twelve young and twelve old men received NR or placebo in a double-blind cross-over design. Before and 2 h after NR (500mg) or placebo supplementation, blood and urine samples were collected, while physical performance (VO2max, muscle strength, and fatigue) was assessed after the second blood sample collection. As mechanism of action the researchers hypothesized that NR supplementation would increase NADH and NADPH levels thus restoring the optimal redox status and improving exercise performance.

The results showed that NR supplementation increased NADH and NADPH levels in both young and old individuals. More precisely by 51% in young and 59% in old individuals after a single dose of 500-mg NR. This was accompanied by favorable outcomes generally appearing in old individuals: (1) decreased urine F2 isoprostanes, (2) tendency for increased erythrocyte GSH, (3) increased erythrocyte LDH activity, (4) increased isometric torque, (5) increased maximal lactate accumulation in blood after the fatigue test, and (6) increased resistance to fatigue.

 

You can find the study here.


Edited by Engadin, 06 March 2019 - 05:50 PM.


#2 Mind

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Posted 06 March 2019 - 06:50 PM

It seems to boost my exercise performance a bit. That is my n=1 subjective experience with NR.



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#3 Engadin

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Posted 06 March 2019 - 09:24 PM

It seems to boost my exercise performance a bit. That is my n=1 subjective experience with NR.

 

 

Older humans, Mind, they say older humans. As far as I know you are far away from the edges of that category  :) .



#4 Heisok

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Posted 06 March 2019 - 11:01 PM

Young was pretty young. There is a large gap. Tough to call what effect it might have on a 55 year old maybe as an example.

 

22.9 +- 1 young 71.5 +- 1 old

 

 



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#5 johnross47

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Posted 07 March 2019 - 07:40 PM

As a 72 year old I find it reassuring. It confirms my personal subjective experience. I started using NR less than a year ago and am much fitter now than I was now. I am doing a lot more exercise but that is partly because I can. Before I started NR, my hips would burn after a couple of miles of walking or running. On a bad day the burn began after a few hundred yards. Today I walked 8 miles with no problem. I am lifting much bigger weights and can hold a plank away beyond the 50 second interval of my circuits class.


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