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[Phoebus]

Was reading today about how critical K channels are for virtually everything in the human body. 

 

 

 

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms.^[1] They form potassium-selective pores that span cell membranes. Furthermore, potassium channels are found in most cell types and control a wide variety of cell functions.^[2][3]

 

K is the key to maintaining the mito membrane and without adequate K the membrane does not function properly. To move nutrients in and out of the mito you need K channels working optimally.  

 

 

 

In this review, we summarize our knowledge about mitochondrial potassium channels, with a special focus on unanswered questions in this field. The following potassium channels have been well described in the inner mitochondrial membrane: ATP-regulated potassium channel, Ca2 +-activated potassium channel, the voltage-gated Kv1.3 potassium channel, and the two-pore domain TASK-3 potassium channel. The primary functional roles of these channels include regulation of mitochondrial respiration and the alteration of membrane potential. Additionally, they modulate the mitochondrial matrix volume and the synthesis of reactive oxygen species by mitochondria. Mitochondrial potassium channels are believed to contribute to cytoprotection and cell death. In this paper, we discuss fundamental issues concerning mitochondrial potassium channels: their molecular identity, channel pharmacology and functional properties. Attention will be given to the current problems present in our understanding of the nature of mitochondrial potassium channels. This article is part of a Special Issue entitled ‘EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2–6, 2016’, edited by Prof. Paolo Bernardi.

https://www.scienced...005272816300536

 

 

So I am wondering if you could chemically bond K to either NR or NMN, thus forming a chemical that is more likely to move across the mito membrane into the mito where we want it than just plain old NR/NMN

 

Any thoughts?