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Coffee contains sirt1, sirt2 and sirt3 inhibitors, relevance?

sirt coffee longevity

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#1 MankindRising

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Posted 08 March 2019 - 09:13 PM


http://www.timelessl...ibits-sirt12-3/

 

Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as Sirt1/2 Inhibitor

https://www.ncbi.nlm...les/PMC4795788/


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#2 tunt01

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Posted 08 March 2019 - 10:05 PM

It would seem to put a damper on coffee during fasting, which I know is a subject of debate.  But it may be specific to hepatocytes and not matter in the rest of the body.  Maybe Green Tea becomes preferred then during a fasted period.  IDK.  Someone should probably contact Jae Park.  Based on his bio, he has spent a lot of time on javamide.


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