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Glioblastoma patients with high expression of an NAD+ pathway gene known as NAMPT died sooner

nad+ brain cancer glioblastoma

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7 replies to this topic

#1 Reven

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Posted 03 April 2019 - 03:44 AM


"There's a lot of buzz about taking NAD+ precursors for their anti-aging effects, which is based on a lot of great science," said Albert H. Kim, MD, PhD, an assistant professor of neurological surgery and the senior author on the study. "We didn't directly demonstrate that taking NAD+ precursors makes tumors grow faster, but one implication of our work is that if you want to take anti-aging NAD+ precursors, you might want to keep in mind that we don't yet understand all the risks."

 

https://www.scienced...61206103526.htm

 

Thoughts?


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#2 bluemoon

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Posted 03 April 2019 - 11:12 AM

How much sooner did they die? The article didn't say.



#3 Daniel Cooper

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Posted 03 April 2019 - 06:11 PM

As long as raising NAD+ doesn't raise the risk of glioblastoma I'm not overly concerned about this.

 

Let's face it, glioblastoma is one of the more aggressive harder to treat cancers out there.  The only one in the same ballpark seems to be the more common forms of pancreatic cancer.  If you get glioblastoma your life expectancy is usually measured in months not years.  If it's 4 months instead of 6 months have you really lost that much compared to the potential upside of boosting NAD+ if you don't get glioblastoma (which is highly likely).

 

 

 


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#4 bluemoon

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Posted 04 April 2019 - 03:04 PM

 If you get glioblastoma your life expectancy is usually measured in months not years. 

 

There has recently been a breakthrough using a polio vaccine: 

 

"Of 23 glioblastoma patients enrolled at the optimal dose level, 15 are still alive and enrollment is ongoing. Three patients treated early using different dosages are still alive more than 36 months after treatment. With current standard therapy, the median survival time for people with glioblastoma is 14.6 months."


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#5 joesixpack

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Posted 05 April 2019 - 04:47 AM

There has recently been a breakthrough using a polio vaccine: 

 

"Of 23 glioblastoma patients enrolled at the optimal dose level, 15 are still alive and enrollment is ongoing. Three patients treated early using different dosages are still alive more than 36 months after treatment. With current standard therapy, the median survival time for people with glioblastoma is 14.6 months."

 

I did not see this in the original story. Is there a link to what you quoted?



#6 bluemoon

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Posted 05 April 2019 - 12:42 PM

I did not see this in the original story. Is there a link to what you quoted? 

 

The Duke Cancer Institute

 

https://tischbraintu...through”-status



#7 ledgf

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Posted 05 April 2019 - 01:08 PM

~90% of cancer cells express telomerase too... that doesn't mean that activating telomerase in your normal cells is bad. 
 

Cancer cells eventually have EVERY growth-enhancing system engaged. That's why every bonehead grad student uses HeLa... they grow fast so the experiments are shorter. (Of course they don't even have a stable chromosome number and have extra copies of growth genes... so they're pretty useless for saying anything about actual human biology ;)


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#8 joesixpack

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Posted 05 April 2019 - 04:57 PM

The Duke Cancer Institute

 

https://tischbraintu...through”-status

 

Thanks, that is very interesting.







Also tagged with one or more of these keywords: nad+, brain cancer, glioblastoma

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