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Cancer Cured in Mice


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164 replies to this topic

#121 dytona

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Posted 24 June 2009 - 04:28 AM

1. Not exact.

Wake Forest Dr. Cui trial and Sout Florida Dr. Maharaj trial is similar but different.

Wakr Forest trial study chair is Dr. Cui and South Florida is Dr. Maharaj.

Two trial based on there are cancer resistance human.

South Florida is not instead of Wake Forest.

The difference between them is blood test of CKA.

South Florida screen donors by family cancer history.

#122 lunarsolarpower

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Posted 24 June 2009 - 09:20 AM

dytona have you contacted Dr. Cui to see if he can provide input to what you're trying to do? Although it is only a single case it would be nice to gather as much information about the process and results as possible for later review.

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#123 dytona

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Posted 24 June 2009 - 11:20 AM

dytona have you contacted Dr. Cui to see if he can provide input to what you're trying to do? Although it is only a single case it would be nice to gather as much information about the process and results as possible for later review.



I sent mail many times. But he reply 3 times.

Here is South Korea. So he can not help. And I think he does not want to.

I request the information about CKA test. But he denied.

Edited by dytona, 24 June 2009 - 11:21 AM.


#124 davidd

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Posted 03 July 2009 - 04:50 PM

dytona,

I just came across this topic. Thank you GREATLY for sharing this information with us. I know that many people appreciate any and all information they can get on granulocyte studies/trials/research/etc..

I do not know the arrangement you have with your labs. Are they doing this free of charge, and that is why they have not released the data to you? I guess what I am asking is, can you get the data from them? If not, why?

Will you be doing a major histocompatibility complex match test? If so, how?

Thanks again for sharing this valuable information with all of us. I wish you and your wife success.

David

#125 Engin

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Posted 05 July 2009 - 07:48 PM

I sent mail many times. But he reply 3 times.

Here is South Korea. So he can not help. And I think he does not want to.

I request the information about CKA test. But he denied.



Dytona,

Any progress that you can share with us?

All the best,
Engin

#126 dytona

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Posted 06 July 2009 - 12:30 AM

Thank you for your interest.

Now I have all data from the lab.

I paid for the test. The interesting thing is target cell is metastatic breast cell.

The lab test was blind test. They guess the highest person will be the 20's male.

But the result wat 19 years old girl studient.(all top 6 was girl studient)

I will shear all the information about granulocyte transfusion.

But at this time, my wife spinal metastasis make heavy pain.

So I have to postphone the transfusion till next month.

My wife have to take chemotherapy( cisplatine + gemza).

After 2 cycle, if the result of chemotherapy will some good.

I will continue the transfusion.

But I worry about the Dr. Zheng Cui's trial cancel.

I cannot understand the university and NCI.

The main reason is lost principle investigator. Who believe that?

I think there are more political issue behind that.

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#127 Engin

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Posted 06 July 2009 - 09:12 AM

Thank you for your interest.

Now I have all data from the lab.

I paid for the test. The interesting thing is target cell is metastatic breast cell.

The lab test was blind test. They guess the highest person will be the 20's male.

But the result wat 19 years old girl studient.(all top 6 was girl studient)

I will shear all the information about granulocyte transfusion.

But at this time, my wife spinal metastasis make heavy pain.

So I have to postphone the transfusion till next month.

My wife have to take chemotherapy( cisplatine + gemza).

After 2 cycle, if the result of chemotherapy will some good.

I will continue the transfusion.

But I worry about the Dr. Zheng Cui's trial cancel.

I cannot understand the university and NCI.

The main reason is lost principle investigator. Who believe that?

I think there are more political issue behind that.


Thank you so much for the update Dytona. I wish you the best.

Chemos are not working for my mother. So i am open to your suggestions.

I am totally agree with you. There are other things behind the cancellation of the trial. Indeed it is obvious. Big Pharma again showed the ugly face... How are they going to explain our losts in the future that there are ways to cure the disease??? Millions are dead with pain and suffering... Millions will die... How are they going to explain this?

Please people rise up your voice... Please if you are using facebook, join our cause... http://apps.facebook...6294?m=3124eff7

All sufferers... May God be with you.

Engin

Edited by Engin, 06 July 2009 - 09:13 AM.


#128 dytona

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Posted 06 July 2009 - 10:42 AM

Thank you.

Sometimes I doubt the granulocyte effect.

But I listen the audio file and watch video clip and study paper.

I am sure this therapy will work at least shrink the tumor.

At the mice test, MHC mismatch case, the female recipant survive over 30%.

Attached Files


Edited by dytona, 06 July 2009 - 10:47 AM.


#129 davidd

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Posted 06 July 2009 - 02:45 PM

dytona,

Thanks again for sharing this information.

Regarding MHC mismatch and decrease in success with age, do you know whether the test on the mice involved only one transfusion or multiple? When I looked at the graphs you provided in the powerpoint (.ppt), I wondered if multiple transfusions could increase the success percentage??

David

#130 dytona

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Posted 07 July 2009 - 12:56 AM

dytona,

Thanks again for sharing this information.

Regarding MHC mismatch and decrease in success with age, do you know whether the test on the mice involved only one transfusion or multiple? When I looked at the graphs you provided in the powerpoint (.ppt), I wondered if multiple transfusions could increase the success percentage??

David


Sorry, I don't know single or mutiple.

But Dr. Cui's experiment for mice, he told multiple injection.

I think if human, there need 4~6 donors to treat 1 patient.

That means survival rate will rise, I think.

Over 2 and half year battle with cancer, my wife and I am some exhausted.

But I think in this summer, I am sure that I transfuse granulocyt.

Everybody who suffer from disease let's hang in.

#131 davidd

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Posted 07 July 2009 - 02:28 AM

But Dr. Cui's experiment for mice, he told multiple injection.

I think if human, there need 4~6 donors to treat 1 patient.


Do you know if that was multiple injections at the same time, or multiple injections over a period of time? I was thinking that giving a transfusion, for example, every month might increase chance of success for the various mismatches (MHC, sex and especially age).

Are you able to share how much the lab costs were for the donor tests and how much it will cost for the transfusions?

Thanks again,

David

#132 Engin

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Posted 07 July 2009 - 09:30 AM

Sorry, I don't know single or mutiple.

But Dr. Cui's experiment for mice, he told multiple injection.

I think if human, there need 4~6 donors to treat 1 patient.

That means survival rate will rise, I think.

Over 2 and half year battle with cancer, my wife and I am some exhausted.

But I think in this summer, I am sure that I transfuse granulocyt.

Everybody who suffer from disease let's hang in.


Hi Dytona,

My mother is in a bad situation. She can not eat effectivelly. So she lost weight and strength. Can you please email me how you are planning to do the transfusion? May be i can arrange it here in Turkey too for my mother.

All the best.
Engin

#133 dytona

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Posted 08 July 2009 - 11:24 AM

I want everybody who interested in Dr. Cui's research join this facebook.

http://apps.facebook...9738?m=cc366e79

#134 dytona

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Posted 30 August 2009 - 01:26 AM

Last friday, the transfusion is over.

3 weeks later, I will have result CT.

#135 niner

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Posted 30 August 2009 - 03:14 AM

Last friday, the transfusion is over.

3 weeks later, I will have result CT.

That is great to hear, dytona. I hope that everything goes well. You are an inspiration to us all.

#136 ppp

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Posted 30 August 2009 - 10:57 PM

Last friday, the transfusion is over.

3 weeks later, I will have result CT.


Good luck with the result.

#137 davidd

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Posted 15 September 2009 - 06:35 PM

Dytona,

Thanks for continuing to share your experiences with us. My thoughts are with you and your wife.

David

#138 AgeVivo

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Posted 16 September 2009 - 07:43 PM

I want everybody who interested in Dr. Cui's research join this facebook.

http://apps.facebook...9738?m=cc366e79

Thanks for continuing to share your experiences there. My thoughts too are with you and your wife.

#139 gwgaston

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Posted 18 September 2009 - 03:59 AM

Dytona has posted an update on the Facebook cause page:

http://apps.facebook...306294/81143665

His comment is:

Hello everyone
My wife CT scan result.
8/18 CT : there are 12~15 region. Max 2 are about 12mm. Rest of them are 4~6mm.
9/17 CT : almost of 4~6mm is not visible. but Max 2 are bigger.
I can not decide next step. wait a couple of weeks or another chemo.



Hopefully he will come back her to discuss.

Edited by frankbuzin, 18 September 2009 - 03:59 AM.


#140 theone

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Posted 18 September 2009 - 06:49 AM

Dytona has posted an update on the Facebook cause page:

http://apps.facebook...306294/81143665

His comment is:

Hello everyone
My wife CT scan result.
8/18 CT : there are 12~15 region. Max 2 are about 12mm. Rest of them are 4~6mm.
9/17 CT : almost of 4~6mm is not visible. but Max 2 are bigger.
I can not decide next step. wait a couple of weeks or another chemo.



Hopefully he will come back her to discuss.



Does any here know how long it took for remission in the mice?

#141 Mind

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Posted 18 September 2009 - 06:56 AM

So he is saying that the small tumors/masses are not visible (they are gone), but the large tumors (12mm) are still there?

#142 ppp

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Posted 18 September 2009 - 09:24 AM

So he is saying that the small tumors/masses are not visible (they are gone), but the large tumors (12mm) are still there?


That's how I interpret it. That isn't uncommon in other immunotherapies, for example dendritic cell vaccines - which is why an increasing number of studies are about patients in remission or at high risk of recurrence rather than with active disease.

#143 kismet

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Posted 18 September 2009 - 03:53 PM

I'm not sure if anyone mentioned it, somewhat off-topic but in realtion to the thread title. Does anyone know how unimpressive the sentence "cancer cured in mice" to actual cancer researchesr must be? I think cancer has been cured in mice countless times, starting, probably, decades ago (think: angiostatin & Judah Folkman).

#144 John Schloendorn

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Posted 18 September 2009 - 04:05 PM

I think cancer has been cured in mice countless times, starting, probably, decades ago (think: angiostatin & Judah Folkman).

Of course the phrase "cancer cure" has been abused a couple of times before, and may thus have a poor reputation. But if you look at the data, I think what they did is a whole lot broader than you average "cancer cure". They have different mouse grafts in mice, different human grafts in mice and one genetically accelerated spontaneous model. Also I am not aware of anybody who achieved the long lasting 100% survival that Cui published. Usually a "cure" means a few weeks life extension and then the follow-up just so happens to terminate (as soon as they start dying).

Edited by John Schloendorn, 18 September 2009 - 04:05 PM.


#145 ihatesnow

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Posted 19 September 2009 - 09:36 AM

http://www.scienceda...90914172638.htm

#146 AgeVivo

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Posted 19 September 2009 - 12:54 PM

If there are 2 main tumor masses, would surgery be the next step?

http://www.scienceda...90914172638.htm

"Protecting miR-200 [a specific RNA] from blockade completely prevented metastasis in (...) mice": interesting but I'm not sure why you post it here: is there any treatment to protect miR-200 from blockade?!?

#147 okdenkai

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Posted 20 September 2009 - 01:16 AM

I'm not sure why the mir-200 link was posted either. Blocking a mir or introducing a small RNA into a tumor is far different than introducing it into a relatively 'homogenous' cell line derived from a tumor and then injected into mice.

To the point about a cure for cancer. Yes, the news media have inappropriately used the phrase. When I first sat in a seminar given by Folkman in 1997 his worked seemed impressive but it was immediately clear he was using cell lines to generate tumors on a syngenic background. Basically, a form of xenografts and not primary tumors. In Folkman's defense, he never said it was a cure and it was James Watson who was misquoted by the NY Times as stating "Judah will have a cure for cancer within two years" (which was corrected a couple of days later).
The problem is, when we talk about cancer we're talking about hundreds of diseases. Like Folkman's group, there are those who want to find a pathway/commonality between all cancer cells or tumor environments but that's still a work in progress.

Cui's group has used the phrase "cure for cancer" and though I think the work holds great promise, that is incredibly premature. The results in mice are an impressive start but a lot more tests need to be done. To somehow eliminate the cancerous cells in PTEN knockout mice and leave behind scar tissue is beyond anything seen before. Primary tumors (those created by defined genetic manipulation or exposure to mutagen/carcinogen) are incredibly difficult to even put a dent in with even some of the most widely used chemotherapeutic drugs. So, at least in my book, that puts the work carried out by Cui's lab among the top promising 'new' therapies. But we don't even know if this mechanism is the same as in human. It could be mere coincidence that human and mice both have some inherent killing mechanism but best case scenario is that it's an evolutionary conserved mechanism.

#148 cillcancer

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Posted 20 September 2009 - 06:40 PM

Sorry for my bad english and for doing anything wrong. I am here the first time. I registered, because of these two studies on white blood cells (granulocytes). My father has malignant melanoma stad. IV far advanced.
The South Florida study has started in April 2009, therefore my question is, does anybody hear about first results ?

#149 Sprengmeister

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Posted 07 October 2009 - 02:36 PM

One of the trials - the one at the Wake Forest University has been withdrawn :((
Could please someone call the institute and ask for the reason(s)?

http://www.clinicalt...T... cui&rank=1

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#150 Mind

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Posted 12 October 2009 - 04:49 PM

Details about the Cui-inspired cancer trial in Florida.

About 75% of US population living today will not die of cancer. It is not uncommon that some people remain cancer-free into their 80s and 90s, even if they are regularly exposed to environmental carcinogens such as air pollutants, cigarette smoking, etc. A frequently asked but unanswered question is why these individuals do not get cancer. There has been a recent report of a colony of cancer-resistant mice developed from a single male mouse that unexpectedly survived challenges of lethal cancer cell injections. In these so-called spontaneous regression/complete resistant (SR/CR) mice, cancer cells are killed by rapid infiltration of leukocytes, mainly of innate immunity. This highly effective natural cancer immunity is inherited and mediated entirely by white blood cells. Moreover, this cancer resistance can be transferred to wild type mice through the transfer of various immune cell types including granulocytes.

This observation raises the possibility that infusion of white blood cells, particularly cells of innate immunity, is a viable anticancer therapy in humans as well.

This proposed trial will test whether white blood cell infusions from healthy unrelated donors can be used to treat cancer. The trial is designed to determine whether responses can be seen in cancer patients after infusion of HLA-mismatched white cells from healthy donors. It is important that the donors and recipients be unrelated and HLA-mismatched to avoid the possibility of transfusion-related Graft vs. Host Disease.






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