So sigma 1 is kind of a new kid on the block but it looks extremely promising. It almost feels like a universal switch that could control everything else - all steroid hormones ad all other neurotransmitters.
Sigma 1 is a chaperone receptor that's located in endoplasmic reticulum, and moves intracellular calcium to the surface of the plasma membrane in response to glutamate stimulation. It's essentially an intracellular signal amplifier. It changes your cellular sensitivity and will affect your dose response to all other drugs.
It's probabably the most important receptor out there and we barely know anything about it.
Endogenous agonists are progesterone, testosterone, pregnenalone, sphingosine and DMT (!)
Dextrometorphan and haloperidol are antagonists.
The trick here is that almost every ligand is either agonist or competitive antagonist depending on the dose. So there needs to be some kind of micro-dosing. I know that I get very different effect from very low dose DHEA vs standard dose DHEA.
But I'm interested to know if anyone has experimented with truly microdosing these substances? Has anyone come across any other sigma 1 ligands or happens to know anything important about it?
Edited by neurobliss, 03 May 2019 - 09:46 PM.
