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Glycerol mimics CR by shifting metabolism away from glycolysis and towards oxidative phosphorylation.
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Glycerol extended lifespan, improved stress resistance, and enhanced locomotory and mitochondria activity.
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Using rotifers, we showed that supplements of 150–300 mM glycerol produced 40–50% lifespan extension.
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Glycerol treatment provided increased resistance to starvation, heat, oxidation, and osmotic stress, but not UV stress.
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Glycerol co-administered with 2-deoxyglucose enhanced the lifespan extending effect of glycerol.
Human dosage would be 3x3g
https://www.ncbi.nlm...les/PMC4149915/