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Glycerine for life extension?

life extension supplements

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3 replies to this topic

#1 Slobec

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Posted 17 May 2019 - 09:05 AM


Highlights
  • Glycerol mimics CR by shifting metabolism away from glycolysis and towards oxidative phosphorylation.

  • Glycerol extended lifespan, improved stress resistance, and enhanced locomotory and mitochondria activity.

  • Using rotifers, we showed that supplements of 150–300 mM glycerol produced 40–50% lifespan extension.

  • Glycerol treatment provided increased resistance to starvation, heat, oxidation, and osmotic stress, but not UV stress.

  • Glycerol co-administered with 2-deoxyglucose enhanced the lifespan extending effect of glycerol.

Human dosage would be 3x3g

 

 

https://www.ncbi.nlm...les/PMC4149915/


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#2 kurdishfella

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Posted 23 April 2021 - 09:11 PM

In otc supplements they contain a lot of glycerine to keep the vitamins or whatever stable and free from bacteria growing too much to destroy. Injected glycerin produces pain that is proportional to total injected dose of glycerin, but individual variation in perceived discomfort is substantial. Total glycerin doses of less than 0.05 ml rarely produce clinically important pain.

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#3 micro2000

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Posted 25 April 2021 - 03:46 AM

Rotifers? Microscopic zooplankton? This has no relevance for humans.
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#4 William Sterog

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Posted 28 April 2021 - 08:57 AM

GTA is a source of glycerol and acetic acid, which has benefits on its own.

https://www.longecit...evels-with-gta/

Edited by William Sterog, 28 April 2021 - 08:58 AM.





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