4 replies to this topic

[VP.]

https://www.scientif...nts/?redirect=1

[smithx]

In a Nature Cell Biology study in February scientists reported a newly discovered role for NAD⁺ metabolism at the intersection of cellular aging and cancer—specifically, in a process called cellular senescence. Senescence occurs when aging, damaged cells stop dividing. The process can help suppress cancer, but it leads cells to produce inflammatory molecules that can also promote cancer growth under certain conditions. In the Nature Cell Biology study, Rugang Zhang of the Wistar Institute, and his colleagues found that in cells entering senescence, rising levels of NAMPT (a major NAD⁺-producing enzyme in mammals) encourage the release of inflammatory and potentially protumor molecules. Consistent with those findings, mice genetically predisposed toward pancreatic cancer developed more precancerous and cancerous growths when they consumed the NAD⁺ precursor NMN. Zhang says more research is needed to fully understand the role of NAD⁺ in cancer, but he adds that “we should be cautious and bear in mind the potential downside of NAD⁺ supplementation as a dietary approach for antiaging.”

 

 

[ryukenden]

https://www.scientif...nts/?redirect=1

Thanks for head up.

We’re currently taking NMN or NR 3-4 days a week. Probably will only take 1-2 days a week now.

Edited by ryukenden, 31 May 2019 - 06:49 AM.

[quizzigal]

I would be more concerned if mice that are not genetically predisposed to pancreatic cancer went on to develop more pre-cancerous and cancerous growths.

 

But those of us who take NAD precursors do need to be aware that we don't know all the risks, and that there probably will be unintended consequences.

[Mind]

Just a note, just a casual observation from years of reading papers and forum discussions. It seems just about anything that might help normal cells (all kinds of nutrients and supplements) will also help cancer cells - because they are essentially the same thing - they are your cells, just that one wants to divide like crazy.

 

If the nutrients and supplements tend to up-regulate your cancer defense mechanisms (and slow aging as well), then it would be an overall benefit.