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National Institutes of Health_Dietary Supplement Fact Sheets

dietary supplement

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#1 Engadin

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Posted 04 June 2019 - 11:17 AM


Search the list below by selecting a letter of the alphabet or by entering a word or phrase in the search box.

 

DIETARY SUPPLEMENT FACT SHEETS



#2 pamojja

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Posted 04 June 2019 - 11:59 AM

Search the list below by selecting a letter of the alphabet or by entering a word or phrase in the search box.

 

DIETARY SUPPLEMENT FACT SHEETS

 

Take for example vitamin C, where the NIH continues to ignore any high-dose studies:

 

 

https://ods.od.nih.g...thProfessional/

 

However, at doses above 1 g/day, absorption falls to less than 50% and absorbed, unmetabolized ascorbic acid is excreted in the urine [4]. Results from pharmacokinetic studies indicate that oral doses of 1.25 g/day ascorbic acid produce mean peak plasma vitamin C concentrations of 135 micromol/L, which are about two times higher than those produced by consuming 200–300 mg/day ascorbic acid from vitamin C-rich foods [10]. Pharmacokinetic modeling predicts that even doses as high as 3 g ascorbic acid taken every 4 hours would produce peak plasma concentrations of only 220 micromol/L [10].

 

3g taken every 4 waking-hours: 3 x 5 =15g. To my knowledge the highest oral dose ever studied (please correct if wrong) were these case-studies from New Zealand:

 

 

We studied 139 consecutive consenting non-diabetic patients in an oncology clinic. The patients had been encouraged as part of their treatment to supplement AA. Self-reported daily intake varied from 0 to 20 g/day. The plasma AA levels ranged from 11.4 to 517 µmol/L and correlated well with the reported intake. Regression analysis of their GHb and plasma AA values showed a statistically significant inverse association (eg, each 30 µmol/L increase in plasma AA concentration resulted in a decrease of 0.1 in GHb).

 

The usual reference range for plasma ascorbic acid is 0.4 - 2.0 mg/dL, which is about 22.7 - 113.6 µmol/L. While the majority of the population is even below 1 mg/dl, mega-dosers in this study had up to 9.1 mg/dl plasma ascorbic acid levels. Though it is also true that mega-dosers would take about 220 times more ascorbic acid than the general population, that doesn't mean it is cleared fast enough, to not still be 10 times higher at any time than in the general population. But the better, even the long-term glucose measurement of HbA1c, glycated hemoglobin (GHB), reduced about 1.6% in mega-dosers compared to non-supplementation in this study!!!

 

The NIH isn't reliable for supplement information. They have too much invested into discrediting Linus Pauling, for being ever able to retract in this case.

 


Edited by pamojja, 04 June 2019 - 12:02 PM.

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#3 Engadin

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Posted 04 June 2019 - 04:02 PM

Pamojja, please take my post a merely informative one, if anything. Personal experimenters here, including myself, should base their experiences on much less conservative info sources, IMHO.


Edited by Engadin, 04 June 2019 - 04:02 PM.

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#4 pamojja

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Posted 04 June 2019 - 06:06 PM

Pamojja, please take my post a merely informative one, if anything.

 

Please also understand whenever disinformation is posted, I can't but object. :)


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